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  • 1 Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, No. 100 Shizi Road, Nanjing, 210028, China
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Summary

Yanghuo Sanqi tablet (YST), combined prescription mainly derived from the leaves of herba epimedii and the roots of Panax notoginseng, is a traditional Chinese medicine (TCM). Flavonoids (icarrin, epimedin A, epimedin B, epimedin C, and baohuoside I) and saponins (notoginsenoside R1, ginsenoside Rgl, and ginsenoside Rbl) are considered as the main bioactive compounds of YST. However, there is no report on quality control of TCMs by simultaneous determination of above-mentioned flavonoids and saponins so far. In this work, for the first time, a high-performance liquid chromatography-diode array detector-evaporative light-scattering detector (HPLC-DAD-ELSD) method was developed to evaluate the quality of YST through a simultaneous determination of five major active flavonoids and three main saponins. Optimum separations were obtained with a Zorbax SB-C18 column by gradient elution with acetonitrile-water as the mobile phase. The drift tube temperature of ELSD was set at 105 °C, and the nebulizing gas flow rate was 2.5 L min−1. The fully validated method was successfully applied to quantify the eight bioactive components in three lot products. This simple, low-cost, and reliable HPLC-DAD-ELSD method provided a new basis for assessing the quality of traditional Chinese medicinal compound preparations (TCMCPs) consisting of many bioactive components.

  • [1]. T.H. Xue R. Roy 2003 Science 300 740741.

  • [2]. D. Normile 2003 Science 299 188190.

  • [3]. X. Xiao Z. Wang Y. Lou 2006 Chin Traditional Herbal Drugs 37 888891.

  • [4]. H.Z. Zheng Z.H. Dong Q. She 1998 Modern Research and Application of Traditional Chinese Medicine Xueyuan Press Beijing, China 4225.

    • Search Google Scholar
    • Export Citation
  • [5]. J.P. Xie W.J. Sun 2006 Strait Pharm. J. 18 1720.

  • [6]. G. Liu J.C. Liu Y.L. Zheng C.X. Zhang 2004 Renshen Yanjiu 2 1018.

  • [7]. D. Sha Y. Chen M. Zhang W. Yang 2008 Chin. J. Pharm. Anal. 28 404407.

  • [8]. X.J. Chen B.L. Guo S.P. Li Q.W. Zhang P.F. Tu Y.T. Wang 2007 J. Chromatogr. A 1163 96104.

  • [9]. X.J. Chen H. Ji Q.W. Zhang P.F. Tu Y.T. Wang B.L. Guo S.P. Li 2008 J. Pharm. Biomed. Anal. 46 226235.

  • [10]. W. Li J.F. Fitzloff 2001 J. Pharm. Pharmacol. 53 16371643.

  • [11]. D.X. Sha M.L. Zhang 2005 China J. Chin. Mater. Med. 30 112115.

  • [12]. J.B. Wan F.Q. Yang S.P. Li Y.T. Wang X.M. Cui 2006 J. Pharm. Biomed. Anal. 41 15961601.

  • [13]. Y.Z. Huang N.S. Wang 2002 Trad. Chin. Drug Res. Clin. Pharmacol. 13 174177.

  • [14]. C.Y. Chen L.W. Qi H.J. Li P. Li L. Yi H.L. Ma D. Tang 2007 J. Sep. Sci. 30 31813192.

  • [15]. L.W. Qi Q.T. Yu L. Yi M.T. Ren X.D. Wen Y.X. Wang P. Li 2008 J. Sep. Sci. 31 97106.

  • [16]. L. Yi L.W. Qi P. Li Y.H. Ma Y.J. Luo H.Y. Li 2007 Anal. Bioanal. Chem. 389 571580.

  • [17]. Q.T. Yu L.W. Qi P. Li L. Yi J. Zhao Z. Bi 2007 J. Sep. Sci. 30 12921299.

  • [18]. Y.J. Wei L.W. Qi P. Li H.W. Luo Y. Ling L.H. Sheng 2007 J. Pharm. Biomed. Anal. 45 775784.

  • [19]. J. Li H. Qi L.W. Qi L. Yi P. Li 2007 Anal Chim Acta. 596 264272.

  • [20]. J. Zhao D. Wang S. Duan J. Wang J. Bai W. Li 2009 Arch. Pharm. Res. 32 989996.

  • [21]. J. Ye X. Zhang W. Dai S. Yan H. Huang X. Liang Y. Li W. Zhang 2009 J. Pharm. Biomed. Anal. 49 638645.

  • [22]. Y. Lu K. Yu H.B. Qu Y.Y. Cheng 2007 Chromatographia 65 1924.

  • [23]. Y.F. Li Y. Wang H.B. Qu Y.Y. Cheng 2008 Chromatographia 67 293297.

  • [24]. H.R. Liang W.M. Yan L. Li L. Jiang L. Dai 1993 Chin. J. Chin. Mater. Med. 18 677679.

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Senior editors

Editor(s)-in-Chief: Kowalska, Teresa

Editor(s)-in-Chief: Sajewicz, Mieczyslaw

Editors(s) Danica Agbaba (University of Belgrade, Belgrade, Serbia);
Ivana Stanimirova-Daszykowska (University of Silesia, Katowice, Poland),
Monika Waksmundzka-Hajnos (Medical University of Lublin, Lublin, Poland)

Editorial Board

R. Bhushan (The Indian Institute of Technology, Roorkee, India)
J. Bojarski (Jagiellonian University, Kraków, Poland)
B. Chankvetadze (State University of Tbilisi, Tbilisi, Georgia)
M. Daszykowski (University of Silesia, Katowice, Poland)
T.H. Dzido (Medical University of Lublin, Lublin, Poland)
A. Felinger (University of Pécs, Pécs, Hungary)
K. Glowniak (Medical University of Lublin, Lublin, Poland)
B. Glód (Siedlce University of Natural Sciences and Humanities, Siedlce, Poland)
K. Kaczmarski (Rzeszow University of Technology, Rzeszów, Poland)
H. Kalász (Semmelweis University, Budapest, Hungary)
I. Klebovich (Semmelweis University, Budapest, Hungary)
A. Koch (Private Pharmacy, Hamburg, Germany)
Ł. Komsta (Medical University of Lublin, Lublin, Poland)
P. Kus (Univerity of Silesia, Katowice, Poland)
D. Mangelings (Free University of Brussels, Brussels, Belgium)
E. Mincsovics (Corvinus University of Budapest, Budapest, Hungary)
G. Morlock (Giessen University, Giessen, Germany)
J. Sherma (Lafayette College, Easton, PA, USA)
R. Skibiński (Medical University of Lublin, Lublin, Poland)
B. Spangenberg (Offenburg University of Applied Sciences, Germany)
T. Tuzimski (Medical University of Lublin, Lublin, Poland)
Y. Vander Heyden (Free University of Brussels, Brussels, Belgium)
A. Voelkel (Poznań University of Technology, Poznań, Poland)
B. Walczak (University of Silesia, Katowice, Poland)
W. Wasiak (Adam Mickiewicz University, Poznań, Poland)

KOWALSKA, TERESA
E-mail: kowalska@us.edu.pl

SAJEWICZ, MIECZYSLAW
E-mail:msajewic@us.edu.pl

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2020
 
Total Cites
650
WoS
Journal
Impact Factor
1,639
Rank by
Chemistry, Analytical 71/83 (Q4)
Impact Factor
 
Impact Factor
1,412
without
Journal Self Cites
5 Year
1,301
Impact Factor
Journal
0,34
Citation Indicator
 
Rank by Journal
Chemistry, Analytical 75/93 (Q4)
Citation Indicator
 
Citable
45
Items
Total
43
Articles
Total
2
Reviews
Scimago
28
H-index
Scimago
0,316
Journal Rank
Scimago
Chemistry (miscellaneous) Q3
Quartile Score
 
Scopus
393/181=2,2
Scite Score
 
Scopus
General Chemistry 215/398 (Q3)
Scite Score Rank
 
Scopus
0,560
SNIP
 
Days from
58
sumbission
 
to acceptance
 
Days from
68
acceptance
 
to publication
 
Acceptance
51%
Rate

2019  
Total Cites
WoS
495
Impact Factor 1,418
Impact Factor
without
Journal Self Cites
1,374
5 Year
Impact Factor
0,936
Immediacy
Index
0,460
Citable
Items
50
Total
Articles
50
Total
Reviews
0
Cited
Half-Life
6,2
Citing
Half-Life
8,3
Eigenfactor
Score
0,00048
Article Influence
Score
0,164
% Articles
in
Citable Items
100,00
Normalized
Eigenfactor
0,05895
Average
IF
Percentile
20,349
Scimago
H-index
26
Scimago
Journal Rank
0,255
Scopus
Scite Score
226/167=1,4
Scopus
Scite Score Rank
Chemistry (miscellaneous) 240/398 (Q3)
Scopus
SNIP
0,494
Acceptance
Rate
41%

 

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Acta Chromatographica
Language English
Size A4
Year of
Foundation
1992
Publication
Programme
2021 Volume 33
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1
Issues
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4
Founder Institute of Chemistry, University of Silesia
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Publisher Akadémiai Kiadó
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ISSN 0236-6290 (Print)
ISSN 2083-5736 (Online)

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