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  • 1 Department of Pharmacology and Pharmacotherapy, United Arab Emirates University, Al Ain, United Arab Emirates
  • | 2 Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
  • | 3 Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary
  • | 4 Biomedical Research Center, University Hospital, Hradec Kralove, Czech Republic
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Summary

HPLC monitoring of pharmacokinetics was done in two body compartments of rats following intramuscular treatments with three different doses of K027, a bispyridinium mono-aldoxime type of antidotes to organoposphate intoxicated subjects. Reversed-phase HPLC separation with electrochemical detections was done to monitor the onset, the maximum level, and offset in K027 concentration. Serum level of K027 showed a fast onset, independently from the doses of K027. Drug level in brain was showing an essentially delayed kinetics.

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