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  • 1 Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-952, Gdańsk, Poland
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Summary

The evaluation of several derivatization procedures for the gas chromatographic analysis of selected anticancer pharmaceuticals (cyclophosphamide, iphosphamide, flutamide, chlorambucil, and melphalan) in the presence of tricyclic antidepressants was carried out. Among the methods, concerning trimethylsilylation, tert-butyldimethylsilylation, and methylation, the most useful was methylation using (trimethylsilyl)diazomethane (TMSD), which is a safe alternative for the common reaction with diazomethane. Most of the anticancer drugs were unstable during derivatization using silylating agents, while antidepressants were stable in all tested conditions. Melphalan was the only compound, for which the results of all tested procedures were not satisfying. The TMSD-based procedure was validated, giving the results possibly suitable for the screening purposes in contaminated environmental samples.

  • [1]. P. Bottoni S. Caroli A.B. Caracciolo 2010 Toxicol. Environ. Chem. 92 549.

  • [2]. T. Heberer 2002 Toxicol. Lett. 131 5.

  • [3]. S.K. Khetan T.J. Collins 2007 Chem. Rev. 107 2319.

  • [4]. E. Zuccato S. Castiglioni R. Fanelli 2005 J. Hazard. Mater. 122 205.

  • [5]. M.J. Benotti R.A. Trenholm B.J. Vanderford J.C. Holady B.D. Stanford S.A. Snyder 2009 Environ. Sci. Technol. 43 597.

  • [6]. J.-P. Besse J.-F. Latour J. Garric 2012 Environ. Int. 39 73.

  • [7]. I.J. Buerge H.-R. Buser T. Poiger M.D. Müller 2006 Environ. Sci. Technol. 40 7242.

  • [8]. K.M. Jensen M.D. Kahl E.A. Makynen J.J. Korte R.L. Leino B.C. Butterworth G.T. Ankley 2004 Aquat. Toxicol. 70 99.

  • [9]. M. Sebire Y. Allen P. Bersuder I. Katsiadaki 2008 Aquat. Toxicol. 90 37.

  • [10]. A. Lajeunesse C. Gagnon S. Sauvé 2008 Anal. Chem. 80 5325.

  • [11]. M.M. Schultz E.T. Furlong D.W. Kolpin S.L. Werner H.L. Schoenfuss L.B. Barber V.S. Blazer D.O. Norris A.M. Vajda 2010 Environ. Sci. Technol. 44 1918.

    • Search Google Scholar
    • Export Citation
  • [12]. W.B. Buchberger 2007 Anal. Chim. Acta 593 129.

  • [13]. A. Togola H. Budzinski 2008 J. Chromatogr., A 1177 150.

  • [14]. T. Gunnar S. Mykkänen K. Ariniemi P. Lillsunde 2004 J. Chromatogr., B 806 205.

  • [15]. M. Caban P. Stepnowski M. Kwiatkowski N. Migowska J. Kumirska 2011 J. Chromatogr., A 1218 8110.

  • [16]. N. Migowska P. Stepnowski M. Paszkiewicz M. Gołębiowski J. Kumirska 2010 Anal. Bioanal. Chem. 397 3029.

  • [17]. Y. Park K.J. Albright Z.Y. Cai M.W. Pariza 2001 J. Agric. Food Chem. 49 1158.

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