Clinical and Experimental Medical Journal
Volume/Issue:
Volume 3: Issue 1
Ursodeoxycholic acid administration from the first trimester in case of a severe early-onset intrahepatic cholestasis of pregnancy
Authors:
Enikő Berkes 1st Department of Obstetrics and Gynaecology, Semmelweis University, Budapest, Hungary
Baross u. 27, H-1088, Budapest, Hungary

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Viktor Nagy 2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary

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, and
János Rigó Jr. 1st Department of Obstetrics and Gynaecology, Semmelweis University, Budapest, Hungary

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Pages:
147–151
Online Publication Date:
01 Mar 2009
Publication Date:
01 Mar 2009
Article Category:
Case Report
DOI:
https://doi.org/10.1556/CEMED.3.2009.1.14
Restricted access

Abstract

Intrahepatic cholestasis of pregnancy is characterized by pruritus, raised maternal liver enzymes and bile acids. It usually presents in the third trimester and rarely before 25 weeks. Ursodeoxycholic acid is the most promising therapy to alleviate symptoms and prevent fetal risk. However, its administration has been restricted for the last trimester as its embryotoxic effect is undetermined. We report here a case of an extremely rare, severe obstetric cholestasis with early onset treated by ursodeoxycholic acid from the 9th week of pregnancy, the earliest ever reported in the literature. The treatment was well tolerated. At the 32nd week urgent caesarean section was performed due to intolerable symptoms, worsening laboratory results and signs of fetal distress. A healthy newborn was delivered. It is concluded that ursodeoxycholic acid in case of a severe early-onset intrahepatic cholestasis may be started in the early pregnancy to improve maternal condition and prevent fetal complications.

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Cover Clinical and Experimental Medical Journal
Clinical and Experimental Medical Journal
Print ISSN:
2060-6249
Online ISSN:
2060-968X

Clinical and Experimental Medical Journal
Language English
Size  
Year of
Foundation		 2007
Publication
Programme		 ceased
Volumes
per Year		  
Issues
per Year		  
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 2060-6249 (Print)
ISSN 2060-968X (Online)

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