Authors:
Zoltán Langmár 2nd Department of Obstetrics and Gynecology, Faculty of Medicine, Semmelweis University, Budapest, Hungary
Department of Radiology and Oncotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary
Üllői út 78/a, H-1082, Budapest, Hungary

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Kálmán Iványi Faculty of Medicine, Semmelweis University, Budapest, Hungary

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Ferenc Bánhidy 2nd Department of Obstetrics and Gynecology, Faculty of Medicine, Semmelweis University, Budapest, Hungary

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László Torgyík Department of Radiology and Oncotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary

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Magdolna Dank Department of Radiology and Oncotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary

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Abstract

Improving survival rates and quality of life following modern combined cancer treatments have resulted in a growing number of patients requesting maintenance of reproductive functions. Few methods are currently available to maintain fertility during oncotherapy. Even though most of them are still experimental and their efficacy and safety have not been determined, the future for fertility preservation in women with cancer is promising. In vitro fertilization with embryo cryopreservation offers an established method, but it could be risky to delay cancer treatment regarding the progression of several cancer types. Moreover, exposure to a high estrogen milieu during ovarian stimulation is undesirable when patients have estrogen sensitive malignant tumors. Cryopreservation of mature oocytes following in vitro fertilization and intracytoplasmatic sperm injection offers advantages, but it is still limited due to its low success rate. Emerging techniques of ovarian tissue cryopreservation followed by autotransplantation have been clinically explored. Novel technologies of tissue freezing and thawing promise improving results. This procedure can be offered in the future for prepubertal girls before cancer treatment to maintain future fertility. Gonadal tissue cryopreservation and transplantation should be considered experimental in humans for the present time until greater evidence regarding efficacy and safety is accrued.

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Clinical and Experimental Medical Journal
Language English
Size  
Year of
Foundation
2007
Publication
Programme
ceased
Volumes
per Year
 
Issues
per Year
 
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2060-6249 (Print)
ISSN 2060-968X (Online)

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