View More View Less
  • 1 2nd Department for Internal Medicine, Medical Faculty, Semmelweis University, Budapest, Hungary
  • 2 Mező u. 28, H-2040, Budaörs, Hungary
Restricted access

Abstract

Abstract

Hepatocellular carcinoma develops frequently following upon chronic hepatitis C- and B virus infections. Hepatitis B virus directly, while hepatitis C virus indirectly play an important rule in hepatocarcinogenesis.

The aim of our work

To demonstrate a very unique and interesting case in which after the elimination of an early detected duplex hepatocellular carcinoma with a combination therapy of PEG-interferon-alfa-2a and ribavirin we could eliminate hepatitis C virus.

Case presentation

53-year-old male patient with chronic hepatitis C infection in his anamnesis. In 1995 histological examination confimed cirrhosis in his liver. One year later he was non-responder for conventional interferon therapy. In 2002 CT examination confirmed a process with multiple plexus in the liver. With cytological proof of hepatocellular carcinoma the resection of the tumor by left-lobectomy of the liver was carried out. Four years after the operation a one year PEG-interferon-alfa-2a and ribavirin combined therapy had been applied. The patient became virologically negative.

Conclusion

In chronic liver diseases a carcinoma may develop at the same time at several centers. PEG-interferon-alfa-2a and ribavirin therapy can be effective in chronic liver disease as well as after resection of estabilished hepatocellular carcinoma.

  • [1]. J. Fehér G. Lengyel 2006 The liver cirrhosis: epidemiology and aetiology Orv. Hetil. 147 Suppl.1 15891594.

  • [2]. Working Group of Department of InfectologyCatastrophe Medicine at the University of Pécs 2007 Differential diagnosis of acute and chronic hepatitis 1 210.

    • Search Google Scholar
    • Export Citation
  • [3]. G. Lengyel L. Kóbori I. Fehérvári 2003 Combined interferon-alfa-2b and ribavirin therapy in chronic hepatitis C following liver transplantation Orv. Hetil. 144 23672370.

    • Search Google Scholar
    • Export Citation
  • [4]. A. Pár L. Telegdy Gógl 1999 The interferon treatment in chronic hepatitis. Five year multi-center study Orv. Hetil. 140 12271233.

    • Search Google Scholar
    • Export Citation
  • [5]. L. Jeffers W. Cassidy C. Howell 2004 Peginterferon alfa-2a (40 kd) and ribavirin for black American patients with chronic HCV genotype 1 Hepatology 39 17021708.

    • Search Google Scholar
    • Export Citation
  • [6]. A. Pár 2002 The hepatiti C virus infection after 12 years. Update in the treatment of chronic hepatitis C Orv. Hetil. 143 266774.

    • Search Google Scholar
    • Export Citation

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Oct 2020 0 0 0
Nov 2020 0 1 0
Dec 2020 0 0 0
Jan 2021 1 0 0
Feb 2021 0 0 0
Mar 2021 0 0 0
Apr 2021 0 0 0