Authors:
Muhammad Liaquat Raza HEJ, International Center for Chemical & Biological Sciences, University of Karachi, Karachi, 75270, Pakistan

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Muhammad Nasir Department of Chemistry, University of Karachi, Karachi, 75270, Pakistan

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Tanveer Abbas Department of Microbiology, University of Karachi, Karachi, 75270, Pakistan

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Baqir Shyum Naqvi Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi, 75270, Pakistan

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Abstract

Catharanthus roseus belongs to the family Apocynaceae, is an erector procumbent herb or undershrub containing latex. It possesses known antibacterial, antimicrobial, antifungal, antidiabetic, anticancer and antiviral activities. In the present study we carried out the screening of this plant for its antibacterial potential adopting the antibacterial assay. The different parts of C. roseus (leaf, stem, flower and root) were used and extracts were subjected to antibacterial assay. The extracts of C. roseus did not exhibit antibacterial activity against Staphylococcus aureus. Moreover, leaf, stem and flower extracts were also ineffective against Pseudomonas aeruginosa. The leave extract did not exhibit activity against Corynebacterium diphtheriae, similarly, the crude extract of stem did not shown activity against Shigella boydii. The most effective was the root extract, which exhibited broad-spectrum antibacterial activity against Salmonella typhi and S. boydii with the zone of inhibitions measuring 24 mm and 22 mm, respectively. The flower extract also showed activity against C. diphtheriae.

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Clinical and Experimental Medical Journal
Language English
Size  
Year of
Foundation
2007
Publication
Programme
ceased
Volumes
per Year
 
Issues
per Year
 
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2060-6249 (Print)
ISSN 2060-968X (Online)

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