The estimated amounts of alcohol consumed regularly are data recorded on the basis of patients’ self-report at history-taking. In many instances, however, patients do not genuinely inform their physician on the extent of their alcohol consumption, and in some cases they simply conceal it. In such cases determination of the amount of carbohydrate-deficient transferrin (CDT) can be helpful.
To determine the levels of carbohydrate-deficient transferrin in a healthy population.
The authors performed examinations among inhabitants of a small Hungarian town (Enese). Data of 409 individuals (average age: 49.7 years) have been processed. They included 204 men (average age: 49.3 years) and 205 women (average age: 50.3 years). Subjects were divided into two groups: 1) those who consumed no alcohol or only small quantities (< 40 g/day) and 2) the so-called social drinkers who consumed an amount corresponding to 40 to 60 g alcohol/day. Levels of carbohydrate-deficient transferrin were measured by immune turbidimetry with an automated instrument Hitachi 912 (Roche USA).
In persons consuming no or only small quantities of alcohol, the levels of CDT rise gradually with the increasing age. In the age group between 45 and 65 years the values are significantly higher than in people under 25 years of age. In the younger age group under 45 years, women were found to have significantly higher levels than men. In the social drinkers (beverage consumption corresponding to 40 to 60 g alcohol/day) the values were higher in all cases as compared to those in the non-consuming group, and in the age group between 45 and 65 years the levels were significantly higher than in the younger age group. Of them, men had significantly higher values as compared to women.
CDT levels show a moderate rise with the age, and social drinking increases the values as well.
[1]. H. Stibler K. G. Kjellin 1976 Isoelectric focusing and electrophoresis of the CSF proteins in tremor of different origins J. Neur. Sci. 30 269–285.
[2]. H. Stibler C. Allgulander K. G. Borg et al.1978 Abnormal microheterogeneity of transferrin in serum and cerebrospinal fluid in alcoholism Acta Med. Scand. 204 49–56.
[3]. T. Arndt 2001 Carbohydrate deficient transferrin as a marker of chronic alcohol abuse: a critical review of preanalysis, analysis, and interpretation Clin. Chem. 47 13–27.
[4]. B. Cylwik L. Chrostek M. Szmitkowski et al.2005 Carbohydrate-deficient isoforms of transferrin (%CDT) and sialic acid (SA) in iron-deficiency anemia Clin. Lab. Haematol. 27 297–301.
[5]. K. Golka R. Sondermann S. E. Reich et al.2004 Carbohydrate-deficient transferrin (CDT) as a biomarker in persons suspected of alcohol abuse Toxicol. Lett. 151 235–241.
[6]. O. Martensson A. Harlin R. Brandt et al.1997 Transferrin isoforms distribution: gender and alcohol consumption Alcohol Clin. Exp. Res. 21 1710–1715.
[7]. A. Korsec T. Arndt M. Bär et al.2001 Trisialo-Fe2-transferrin does not improve the diagnostic accuracy of carbohydrate-deficient trransferrin as a marker of chronic excesive alcohol intake J. Lab. Med. 25 407–410.
[8]. Arndt, T., Korzec, A., Bär, M. et al.: Further arguments against including trisialo-Fe2-transferrin in carbohydrate-deficient transferrin (CDT): a study on male alcoholics and hazardous drinkers. Med. Sci. Monit., 2002, 8, CR411–8.
[9]. L. Chrostek B. Cylwik M. Szmikowski et al.2006 The diagnostic accuracy of carbohydrate deficient transferrin, sialic acid and commonly used markers of alcohol abuse during abstinence Clin. Chim. Acta 364 167–171.
[10]. F. Bortolotti M. Trettene R. Gottardo et al.2007 Carbohydrate-deficient transferrin (CDT): a reliable indicator of the risk of driving under the influence of alcohol when determined by capillary electrophoresis Forensic Sci. Int. 170 175–178.
[11]. J. Fehér G. Lengyel G. Szabó 2006 Carbohydrate-deficient transferrin as the marker of alcohol abuse Orv Hetil. 147 1915–1920.
[12]. H. Stibler S. Borg M. Joustra 1986 Micro anion exchange chromatography of carbohydrate deficient transferrin in serum inrelation to alcohol consumption (Swedish Patent 8400587-5) Alcohol Clin. Exp. Res. 10 535–544.
[13]. H. Myrick S. Henderson R. F. Anton 2001 Utility of a new assay for carbohydrate-deficient transferrin (BIORAD %CDT TIA) to monitor abstinence during treatment outcome study Alcohol Clin. Exp. Res. 25 1330–1334.
[14]. R. F. Anton C. Dominick M. Bigelow CDTect Research Group et al.2001 Comparison of Bio-Rad %CDT TIA and CDTect as laboratory markers of heavy alcohol use and their relationships with gamma-glutamyltransferase Clin. Chem. 47 1769–1775.
[15]. N. B. Figlie A. A. Benedito-Silva M. G. Monteiro et al.2002 Biological markers of alcohol consumption in nondrinkers, drinkers, and alcohol-dependent Brazilian patients Alcohol Clin. Exp. Res. 26 1062–1069.
[16]. M. Fleming M. Mundt 2004 Carbohydrate deficient transferrin: Validity of new alcohol biomarker in a sample of patients with diabetes and hypertension J. Am. Board Fa. Pract. 17 247–255.
[17]. M. F. Fleming R. F. Anton C. D. Spies 2004 A review of genetic, biological, pharmacological, and clinical factors that affect carbohydrate-deficient transferrin levels Alcohol Clin. Exp. Res. 28 1347–1355.
[18]. O. Niemela 2007 Biomarkers in alcoholism Clin. Chim. Acta 377 39–49.
[19]. J. R. Delanghe A. Helander J. P. Wielders et al.2007 Development and Multicenter Evaluation of the N Latex CDT Direct Immunonephelometric Assay for Serum Carbohydrate-Deficient Transferrin Clin. Chem. 53 1115–1121.