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  • 1 Dept. of Traumatology, Reconstructive Surgery, Hand Surgery, University of Pécs, Szombathely, Hungary
  • | 2 Central Laboratory, Markusovszky Teaching Hospital of County Vas, University of Pécs, Szombathely, Hungary
  • | 3 Department of Practical Diagnostic of Institute of Diagnostics and Management, University of Pécs, Szombathely, Hungary
  • | 4 Király str. 11, H-9700, Szombathely, Hungary
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Abstract

Mesenchymal stem cells are known as multipotent and exhibit the potential for differentiation into different cells/tissue lineages, including cartilage, bone, adipose tissue, tendon, ligament. These pluripotent mesenchymal progenitor cells are denoted as stromal or mesenchymal stem cells. Bone marrow contains two main cell types: hematopoetic cells and stromal cells. The stem cells for non-hematopoetic tissues are referred as mesenchymal cells because of their ability to differentiate as mesenchymal or stromal cells. Mesenchymal cells are easily obtainable from bone marrow by means of minimally invasive approach and can be expanded in culture and permitted to differentiate into the desired lineage. The differentiation can be reached by the application of bioactive, signaling molecules, specific growth factors. The transforming growth factor beta (TGFβ) superfamily member proteins such as the bone morphogenetic proteins (BMPs) are the most important factors of chondrogenic and osteogenic differentiation of mesencymal stem cells. From the series of recently indentified, BMP 2,4 and 7 may play an important role in chondrogenic and osteogenic differentiation proteins. Little is still known about the signaling pathway involved in tenogenesis of mesenchymal stem cells, but there are some encouraging data about fibroblastic differentiation and affects of growth factors. The success of growth factor therapy needs a delivery system with biomaterials. Mesenchymal stem cells have become promising vehicles for gene therapy, cell therapy and tissue engineering. The authors deal in these review with the experimental investigations and with the clinical application of the adult bone marrow derived mesenchymal stem cells with bioactive molecules, growth factors.

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Clinical and Experimental Medical Journal
Language English
Size  
Year of
Foundation
2007
Publication
Programme
ceased
Volumes
per Year
 
Issues
per Year
 
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2060-6249 (Print)
ISSN 2060-968X (Online)

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