Clinical and Experimental Medical Journal
Volume/Issue:
Volume 3: Issue 3
One hundred and fifty autologous peripheral haemopoietic stem cell transplantations performed at the Department of Medicine, Debrecen University Medical Centre and lessons drawn from them
Authors:
Attila Kiss 2nd and 3rd Departments of Medicine, Debrecen University Medical Centre, Debrecen, Hungary
Cell Therapy Centre, Debrecen, Hungary
2nd and 3rd Departments of Medicine, Debrecen University Medical Centre, Nagyerdei krt. 98, H-4012, Debrecen, Hungary

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Gyula Reményi 2nd and 3rd Departments of Medicine, Debrecen University Medical Centre, Debrecen, Hungary
Cell Therapy Centre, Debrecen, Hungary

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Róbert Szász 2nd and 3rd Departments of Medicine, Debrecen University Medical Centre, Debrecen, Hungary
Cell Therapy Centre, Debrecen, Hungary

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Péter Batár 2nd and 3rd Departments of Medicine, Debrecen University Medical Centre, Debrecen, Hungary
Cell Therapy Centre, Debrecen, Hungary

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László Rejtő 2nd and 3rd Departments of Medicine, Debrecen University Medical Centre, Debrecen, Hungary
Cell Therapy Centre, Debrecen, Hungary

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László Váróczy 2nd and 3rd Departments of Medicine, Debrecen University Medical Centre, Debrecen, Hungary
Cell Therapy Centre, Debrecen, Hungary

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Tamás Sípos 2nd and 3rd Departments of Medicine, Debrecen University Medical Centre, Debrecen, Hungary
Cell Therapy Centre, Debrecen, Hungary

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Erika Kovács 2nd and 3rd Departments of Medicine, Debrecen University Medical Centre, Debrecen, Hungary
Cell Therapy Centre, Debrecen, Hungary

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Marianna Szarvas 2nd and 3rd Departments of Medicine, Debrecen University Medical Centre, Debrecen, Hungary
Cell Therapy Centre, Debrecen, Hungary

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Miklós Udvardy 2nd and 3rd Departments of Medicine, Debrecen University Medical Centre, Debrecen, Hungary
Cell Therapy Centre, Debrecen, Hungary

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Pages:
431–442
Online Publication Date:
01 Sep 2009
Publication Date:
01 Sep 2009
Article Category:
Research Article
DOI:
https://doi.org/10.1556/CEMED.3.2009.28557
Keywords:
haemopoietic; stem cell; autologous; transplantation; harvesting; conditioning; remission; probability of survival; AChE, acetylcholinesterase; AML M4, acute myeloid leukaemia, myelomonocytic subgroup; ANC, absolute neutrophil count; ATG, antithymocyte globulin; BEAM, bischloroethylnitrosourea, etoposide, cytosine arabinoside, melphalan; CD34, cluster of differentiation marker subgroup 34; CIC, centre international code; CML, chronic myeloid leukaemia; CT, computer tomography; DAAD, Deutscher Akademischer Austausch Dienst (German Academic Exchange Service); DHAP, dexamethasone, high-dose cytarabine, cisplatin; EBMT, European Group for Blood and Marrow Transplantation; ES, extrasystole; GCP, good clinical practice; GMP, good manufacturing practice; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; Hyper-C-VAD, high dose cytarabine, etoposide, dexamethasone; ITU, intensive therapy unit; KGF, keratinocyte growth factor; MNC, mononuclear cells; NHL, non-Hodgkin lymphoma; OHII, Országos Haematológiai és Immunológiai Intézet (National Institute of Haematology and Immunology); ST, survival time; TBI, total body irradiation; Tx, transplantation; VGPR, very good partial remission; VID, Vepesid (etoposide), ifosfamide, dexamethasone; WHO, World Health Organisation; Z-BEAM, BEAM, completed with ibritumomab tiuxetan (Zevalin)
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Abstract

Introduction: Six years ago (in September 2003), the fifth Haemopoietic Stem Cell Transplantation Centre of Hungary began its activity. This centre registered as the No. 648 sub-centre of the European Blood and Marrow Transplantation Committee.

Objectives: To meet the demand for transplantation of haemopoietic stem cells in the North-Eastern regions of Hungary and to establish active connections with the domestic and international centres.

Methods: The interventions were performed in accordance with international criteria.

Results: Up to now 150 autologous stem cell transplantations were performed including 74 patients with multiple myeloma, 43 with non-Hodgkin lymphoma, one with chronic lymphoid leukaemia, 27 with Hodgkin's disease, four patients with autoimmune disease, and one with leiomyosarcoma. Survival rates were similar to Hungarian and international data. The centre has taken a role also in other activities using stem cell therapy at the University of Debrecen (dendritic cell-based vaccine program, stem cell therapy in myocardial infarction, peripheral arterial disease, and autoimmune diseases). This centre performed the most use of conditioning protocol Zevalin (ibritumomab tiuxetan), bischloroethylnitrosourea, etoposide, cytosine arabinoside, and melphalan (Z-BEAM) in patients with non-Hodgkin lymphoma in Hungary (ten patients were treated).

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Cover Clinical and Experimental Medical Journal
Clinical and Experimental Medical Journal
Print ISSN:
2060-6249
Online ISSN:
2060-968X

Clinical and Experimental Medical Journal
Language English
Size  
Year of
Foundation		 2007
Publication
Programme		 ceased
Volumes
per Year		  
Issues
per Year		  
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 2060-6249 (Print)
ISSN 2060-968X (Online)

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