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Judit Jeager 1st Department of Obstetrics and Gynecology, Semmelweis University, Faculty of Medicine, Budapest, Hungary

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Zsófia Schuler Faculty of Medicine, Semmelweis University, Budapest, Hungary

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Attila Molvarec 1st Department of Obstetrics and Gynecology, Semmelweis University, Faculty of Medicine, Budapest, Hungary

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Mónika Perlaki 1st Department of Obstetrics and Gynecology, Semmelweis University, Faculty of Medicine, Budapest, Hungary

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Lilla Sassi 1st Department of Obstetrics and Gynecology, Semmelweis University, Faculty of Medicine, Budapest, Hungary

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Barbara Kőhalmi 1st Department of Obstetrics and Gynecology, Semmelweis University, Faculty of Medicine, Budapest, Hungary

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Mihály Silhavy 1st Department of Obstetrics and Gynecology, Semmelweis University, Faculty of Medicine, Budapest, Hungary

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Ágnes Harmath 1st Department of Obstetrics and Gynecology, Semmelweis University, Faculty of Medicine, Budapest, Hungary

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János Rigó 1st Department of Obstetrics and Gynecology, Semmelweis University, Faculty of Medicine, Budapest, Hungary

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Éva Görbe 1st Department of Obstetrics and Gynecology, Semmelweis University, Faculty of Medicine, Budapest, Hungary
1st Department of Obstetrics and Gynecology, Semmelweis University, Faculty of Medicine, Baross u. 27, H-1088, Budapest, Hungary

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Abstract

Methods: Investigating the combined effect of administering surfactant at delivery, antenatal steroid prophylaxis, reduced oxygen concentration and lowered pressure of mechanical ventilation, early weaning and extubation, as well as supplementation of vitamins A and C on the development of bronchopulmonary dysplasia of very low birth weight infants. Experimental subjects were 13 very low birth weight preterm infants, born between September 2007 and February 2008, selected as being at high risk of developing bronchopulmonary dysplasia on the basis of their IL-6 levels (obtained from tracheal aspirate and whole blood) taking CRP into consideration as well. These subjects were given the aforementioned treatment alternative to the one generally used and professionally recommended. Newborns with normal IL-6 levels in tracheal aspirate were considered the “normal” group and received the treatment traditionally recommended for premature babies.

Results: 50% of the infants needed HFO ventilation (for 4 to 11 days). All infants needed synchronized intermittent mandatory ventilation (for 2 to 17 days). 17% of them also received continuous positive airway pressure treatment (for 2 to 7 days). The incidence of bronchopulmonary dysplasia was 16.66%.

Conclusions: For very low birth weigh infants with risk for developing bronchopulmonary dysplasia the combined use of surfactant therapy, antenatal steroid prophylaxis, lowered oxygen saturation goals, early weaning and extubation, and A and C vitamin supplementation has resulted in decreased incidence of bronchopulmonary dysplasia.

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Clinical and Experimental Medical Journal
Language English
Size  
Year of
Foundation
2007
Publication
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ceased
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per Year
 
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Publisher Akadémiai Kiadó
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H-1117 Budapest, Hungary 1516 Budapest, PO Box 245
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Chief Executive Officer, Akadémiai Kiadó
ISSN 2060-6249 (Print)
ISSN 2060-968X (Online)

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