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  • 1 Department of Pathology, Jos University Teaching Hospital, Pmb 2076, Jos, Nigeria
  • 2 Department of Medicine, Jos University Teaching Hospital, Pmb 2076, Jos, Nigeria
  • 3 Department of Paediatrics, Plateau State Specialist Hospital, Jos, Nigeria
  • 4 Department of Pathology, Jos University Teaching Hospital (JUTH), Pmb, 2076, Jos, Nigeria
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Abstract

Background: Human immunodeficiency virus and tuberculosis (HIV/TB) co-infection in an individual constitutes a serious diagnostic and therapeutic challenge. Objective: To determine liver pathology in patients with HIV and TB co-infection. Methods: Postmortem liver biopsy was done on patients with HIV/TB co-infection. The tissues were subjected to routine histological processing. The sections were stained with haematoxylin and eosin, including special stains. Results: Sixty-seven biopsies from 67 patients (33 men and 34 women) were analysed. Thirty-nine (58.2%) had pulmonary tuberculosis (PTB) while 26 (38.8%) had disseminated tuberculosis (DTB). Two (3%) had tuberculous meningitis (TBM). Fourteen (36%) patients with PTB, 10 (38%) with DTB and one (50%) with TBM had hepatic granuloma with caseation. Histologically granuloma 25 (37.4%), chronic hepatitis 13 (19.4%), nonspecific reactive hepatitis (NSRH) 11(16.4%), steatosis nine (13.4%) and cirrhosis seven (10.4%) were found. Conclusion: This study showed that the liver is frequently involved by TB in HIV/TB co-infection.

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