View More View Less
  • 1 MacLeod Laboratory, New York Presbyterian Medical Center, New York, USA
  • 2 New York Presbyterian Medical Center, New York, USA
  • 3 MacLeod Laboratory, New York Presbyterian Medical Center, 65 East 79th Street, New York, NY, 10075, USA
Restricted access

Abstract

Objective: To determine whether broad-spectrum antibiotic therapy administered after a failed in vitro fertilization (IVF) cycle will improve the chance of achieving a successful pregnancy in the subsequent IVF cycle and to determine whether further antibiotic therapy administered immediately after conception, during the course of pregnancy, and at the time of delivery will reduce the incidence of maternal and fetal complications. Design: A retrospective analysis was performed on the clinical data of 63 couples who had previously failed one or more IVF cycles and were subsequently treated with broad-spectrum antibiotics. All women were treated with intravenous Clindamycin and daily intrauterine lavages using a broad-spectrum antibiotic combination. All men received intravenous Clindamycin and simultaneously underwent five direct transrectal injections of an antibiotic cocktail into the prostate gland if clinical or sonographic evidence of chronic prostatitis was documented. For both men and women, these regimens were followed by a month-long oral course of Zithromax and Macrobid. Following either a spontaneous pregnancy or a repeat IVF conception, a 10-day antibiotic course was administered in the form of oral Cleocine or intravenous Clindamycin. Some women received intermittent oral antibiotic courses throughout the pregnancy and prophylactic antibiotics during delivery. Results: When compared with our previous study (Study I, [24]), the number of spontaneous pregnancies was significantly higher and the total number of births was also significantly higher. Following the antibiotic therapy, there was a significantly improved chance for the couples to achieve a successful IVF pregnancy when compared to historical controls in conventional repeat IVF cycles. For singleton pregnancies, there were no perinatal maternal or fetal complications. Conclusion: These results support our previous findings, showing that antibiotic therapy can reduce IVF failures in subsequent cycles. The reduced number of maternal and fetal complications after antibiotic therapy in this retrospective study is impressive and warrants a prospective, randomized trial for confirmation.

  • [1]. R. Klemetti M. Gissler E. Hemminiki 2002 Comparison of perinatal health of children born from IVF in Finland in the early and late 1990s Hum. Reprod. 17 21922198.

    • Search Google Scholar
    • Export Citation
  • [2]. M. Bondurlle U. B. Wennerholm A. Loft 2005 A multi-center cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception Hum. Reprod. 20 413419.

    • Search Google Scholar
    • Export Citation
  • [3]. A. K. Schroder A. Katalinic K. Diedrich M. Ludwig 2004 Cumulative pregnancy rates and drop-out rates in a German IV program: 4102 cycles in 2130 patients Reprod. Biomed. Online 8 600606.

    • Search Google Scholar
    • Export Citation
  • [4]. V. Sharma V. Allgar M. Rajkhowa 2002 Factors infl uencing the cumulative conception rate and discontinuation of in vitro fertilization treatment for infertility Fertil. Steril. 78 4046.

    • Search Google Scholar
    • Export Citation
  • [5]. C. Witsenburg S. Dieben L. Van der Westerlaken H. Verburg N. Naaktgeboren 2005 Cumulative live birth in cohorts of patients treated with in vitro fertilization or intracytoplasmic sperm injection Fertil. Steril. 84 99107.

    • Search Google Scholar
    • Export Citation
  • [6]. B. Bartoov A. Berkovitz F. Eltes A. Kogosovsky A. Yagoda H. Lederman S. Artzi M. Gross Y. Barak 2003 Pregnancy rates are higher with intracytoplasmic morphologically selected sperms then with conventional intracytoplasmic injection Fertil. Steril. 80 14131419.

    • Search Google Scholar
    • Export Citation
  • [7]. B. A. Malizia M. R. Hacker A. S. Penzias 2009 Cumulative live-birth rates after in vitro fertilization N. Engl. J. Med. 360 236243.

    • Search Google Scholar
    • Export Citation
  • [8]. S. E. Elizur L. Lerner-Geva J. Levron A. Shulman D. Bider J. Dor 2006 Cumulative live birth rate following in vitro fertilization: study of 5,310 cycles Gynecol. Endocrinol. 22 1 2530.

    • Search Google Scholar
    • Export Citation
  • [9]. V. Sharma V. Allgar M. Rajkhowa 2002 Factors influencing the cumulative conception rate and discontinuation of in vitro fertilization treatment for infertility Fertil. Steril. 78 4046.

    • Search Google Scholar
    • Export Citation
  • [10]. D. Navot P. A. Bergh M. A. Williams 1991 Poor oocytes quality rather than implantation failure as a cause of age-related decline in female fertility Lancet 337 13751377.

    • Search Google Scholar
    • Export Citation
  • [11]. E. E. Wallach 1995 Pitfalls in evaluating ovarian reserve Fertil. Steril. 63 1214.

  • [12]. H. I. Abdalla R. Baber A. Kirkland T. Leonard M. Power J. W. Studd 1990 A report on 100 cycles of oocytes donation: factors affecting the outcome Hum. Reprod. 5 101822.

    • Search Google Scholar
    • Export Citation
  • [13]. S. Munn M. Alikani G. Tomlin J. Grifo J. Cohen 1995 Embryo morphology, developmental rates, and maternal age correlated with chromosome abnormalities Fertil. Steril. 64 382391.

    • Search Google Scholar
    • Export Citation
  • [14]. A. Lass C. Croucher S. Duffy K. Dawson R. Margara R. L. Winston 1998 One thousand initiated cycles of in vitro fertilization in women >40 years of age Fertil. Steril. 70 10301034.

    • Search Google Scholar
    • Export Citation
  • [15]. R. Romero J. Espinoza M. Mazor 2004 Can endometrial infection/inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization? Fertil. Steril. 82 799804.

    • Search Google Scholar
    • Export Citation
  • [16]. S. S. Witkin I. Kligman J. A. Grifo Z. Rosenwaks 1995 Chlamydia trachomatis detected by polymerase chain reaction in cervices of culture-negative women correlates with adverse in vitro fertilization outcome J. Infect. Dis. 171 16571659.

    • Search Google Scholar
    • Export Citation
  • [17]. B. S. Hurst K. F. Tucker C. A. Awoniyi W. D. Schlaff 2001 Hydrosalpinx treated with extended doxycycline does not compromise the success of in vitro fertilization Fertil. Steril. 75 10171019.

    • Search Google Scholar
    • Export Citation
  • [18]. R. Peikrishvili B. Evrard J. L. Pouly L. Janny 2004 Prophylactic antibiotic therapy (amoxicillin + clavulenic acid) before embryo transfer for IVF is useless. Results of a randomized study J. Gynecol. Obstet. Biol. Reprod. (Paris) 33 8 713719.

    • Search Google Scholar
    • Export Citation
  • [19]. P. G. McGovern A. J. Llorens J. H. Skurnick G. Weiss L. T. Goldsmith 2004 Increased risk of preterm birth in singleton pregnancies resulting from in vitro fertilization-embryo transfer or gamete intrafallopian transfer: a meta-analysis Fertil. Steril. 82 15141520.

    • Search Google Scholar
    • Export Citation
  • [20]. A. Templeton J. K. Morris W. Parslow 1996 Factors that affect outcome of in-vitro fertilization treatment Lancet 348 14021406.

  • [21]. R. A. Jackson K. A. Gibson Y. W. Wu M. S. Crougham 2004 Perinatal outcome in singletons following in vitro fertilization: a meta-analysis Obstet. Gynecol. 103 3 551563.

    • Search Google Scholar
    • Export Citation
  • [22]. A. Toth M. L. Lesser C. Brooks D. Labriola 1983 Subsequent pregnancies among 161 couples treated for T-mycoplasma genital-tract infection N. Engl. J. Med. 308 505507.

    • Search Google Scholar
    • Export Citation
  • [23]. A. Toth M. L. Lesser C. Brooks 1986 Outcome of subsequent pregnancies following antibiotic therapy after primary or multiple miscarriages Surg. Gyn. Obst. 163 243250.

    • Search Google Scholar
    • Export Citation
  • [24]. A. Toth M. L. Lesser 2007 Outcome of subsequent IVF cycles following antibiotic therapy after primary or multiple previously failed IVF cycles Int. J. Gynecol. Obstet. 7 1.

    • Search Google Scholar
    • Export Citation
  • [25]. W. L. Hu S. Z. Zhong H. X. He 2002 Treatment of chronic bacterial prostatitis with amikacin through anal submucosal injection Asian J. Androl. 4 3 163167.

    • Search Google Scholar
    • Export Citation
  • [26]. J. S. Mayersak 1998 Transrectal ultrasonography directed intraprostatic injection of gentamicin-xylocaine in the management of the benign painful prostate syndrome. A report of a 5-year clinical study of 75 patients Int. Surg. 83 4 347349.

    • Search Google Scholar
    • Export Citation
  • [27]. I. Yavaşçaoğlu H. Camlikiyi B. Oktay Simşek M. Ozyurt 1998 Percutaneous suprapubic transvesical route: a new and comfortable method of intraprostatic injection Urol. Int. 60 4 229234.

    • Search Google Scholar
    • Export Citation
  • [28]. M. Yamamoto H. Hibi K. Satoshi K. Miyake 1996 Chronic bacterial prostatitis treated with intraprostatic injection of antibiotics Scand. J. Urol. Nephrol. 30 3 199202.

    • Search Google Scholar
    • Export Citation
  • [29]. F. Guercini 2007 Chronic prostatitis (CP)/chronic pelvic pain syndrome (CPPS): what do we know? Arch. Ital. Urol. Androl. 79 2 7683.

    • Search Google Scholar
    • Export Citation
  • [30]. D. A. Shoskes 2009 Chronische Prostatitis/chronische. Beckenschmerzsyndrom Der Urologe 48 13391345.

  • [31]. N. H. Liversedge J. M. Jenkins S. D. Keay 1996 Antibiotic treatment based on seminal cultures from asymptomatic male partners in in-vitro fertilization is unnecessary and may be detrimental Hum. Reprod. 11 6 12271231.

    • Search Google Scholar
    • Export Citation
  • [32]. S. R. Steyaert G. G. Leroux-Roels M. Dhont 2000 Infections in IVF: review and guidelines Hum. Reprod. Update 6 432441.

  • [33]. S. Cousens H. Blencowe M. Gravett J. E. Lawn 2010 Antibiotics for pre-term pre-labour rupture of membranes: prevention of neonatal deaths due to complications of pre-term birth and infection Int. J. Epidemiol. 39 Suppl1 i134i143.

    • Search Google Scholar
    • Export Citation
  • [34]. S. Kalwij M. Macintosh P. Baraitser 2010 Screening and treatment of Chlamydia trachomatis infections BMJ. c1915 340.

  • [35]. A. Bahadi D. El Kabbaj H. Elfazazi R. Abbi M. R. Hafidi M. M. Hassani R. Moussaoui M. Elouennass M. Dehayni 2010 Oualim Z. Urinary tract infection in pregnancy Saudi. J. Kidney Dis. Transpl. 21 2 342344.

    • Search Google Scholar
    • Export Citation
  • [36]. Y. Ahmed P. Mwaba J. Grange C. Green A. Zumla 2010 Community-based interventions to reduce maternal mortality Lancet 375 9713 457458.

    • Search Google Scholar
    • Export Citation
  • [37]. O. Y. Misyurina E. V. Chipitsyna Y. P. Finashutina 2004 Mutations in a 23S rRNA gene of Chlamydia trachomatis associated with resistance to macrolides. Antimicrob Agents Chemother. 48 13471349.

    • Search Google Scholar
    • Export Citation
  • [38]. A. Kutlin S. Kohlhoff P. Roblin M. R. Hammerschlag P. Riska 2005 Emergence of resistance to rifampin and rifalazil in Chlamydophila pneumoniae and Chlamydia trachomatis Antimicrob. Agents Chemother. 49 903907.

    • Search Google Scholar
    • Export Citation
  • [39]. B. Kallen O. Finnstrom K. G. Nygren P. Otterblad Olausson U. B. Wennerholm 2005 In vitro fertilization in Sweden: obstetric characteristics, maternal morbidity and mortality BJOG 112 15291535.

    • Search Google Scholar
    • Export Citation
  • [40]. W. Ombelet I. Cadron J. Gerris 2005 Obstetric and perinatal outcome of 1655 ICSI and 3974 IVF singleton and 1102 ICSI and 2901 IVF twin birth: a comparative analysis Reprod. Biomed. Online 11 7685.

    • Search Google Scholar
    • Export Citation
  • [41]. E. Maman E. Lunenfeld A. Levy H. Vardi G. Potashnil 1998 Obstetric outcome of singleton pregnancies conceived by in vitro fertilization and ovulation induction compared with those conceived spontaneously Fertil. Steril. 70 240245.

    • Search Google Scholar
    • Export Citation
  • [42]. A. G. Sutcliffe M. Ludwig 2007 Outcome of assisted reproduction Lancet 370 351359.

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Jul 2020 4 0 0
Aug 2020 1 0 0
Sep 2020 2 0 0
Oct 2020 3 0 0
Nov 2020 2 20 5
Dec 2020 1 0 0
Jan 2021 0 0 0