Authors:
Golla Nagesh Babu REQUIMTE, Departamento de Química-Fisica, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal
Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
REQUIMTE, Departamento de Química-Fisica, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha, 164, 4099-030, Porto, Portugal

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Alok Kumar Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India

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Jayantee Kalita Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India

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U. K. Misra Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India

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Abstract

Background: Amyotrophic lateral sclerosis (ALS) is a degenerative disease characterized by progressive depletion of motor neurons in brain, brain stem, and spinal cord, whereas Hirayama disease (HD) results from anterior horn cell loss in the lower cervical cord. On the other hand, matrix metalloproteinases (MMPs) are known to digest components of the extracellular matrix. Of these, MMP-9 is considered as a marker of neuroinflammation. Materials and methods: We have measured MMP-9 levels in the serum of 30 patients with ALS, 10 patients of HD, and 25 healthy controls using ELISA method. Results: MMP-9 levels were significantly elevated in the patients suffering from ALS (P < 0.01) and HD (P < 0.05). Furthermore, MMP-9 levels in ALS have a significant positive correlation (R2 = 0.9) with the duration of the disease. Conclusions: These results suggest that neuroinflammation is an underlying component in ALS pathology and further opens up the search for suitable biomarkers.

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Clinical and Experimental Medical Journal
Language English
Size  
Year of
Foundation
2007
Publication
Programme
ceased
Volumes
per Year
 
Issues
per Year
 
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2060-6249 (Print)
ISSN 2060-968X (Online)

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