Authors:
Á. Nemeskéri Department of Human Morphology and Developmental Biology, Semmelweis University, Budapest, Hungary
Department of Human Morphology and Developmental Biology, Semmelweis University, Tűzoltó u. 58, H-1090, Budapest, Hungary

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B. Matlakovics Department of Human Morphology and Developmental Biology, Semmelweis University, Budapest, Hungary

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I. Dudás Department of Diagnostic Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary

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B. Molnár Department of Diagnostic Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary

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A. Bartykowski Department of Human Morphology and Developmental Biology, Semmelweis University, Budapest, Hungary

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M. Kiss Department of Human Morphology and Developmental Biology, Semmelweis University, Budapest, Hungary

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I. Kristóf Department of Forensic and Insurance Medicine, Semmelweis University, Budapest, Hungary

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K. Törő Department of Forensic and Insurance Medicine, Semmelweis University, Budapest, Hungary

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K. Karlinger Department of Diagnostic Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary

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Abstract

In recent years, post mortem multi-slice computed tomography (MSCT) is increasingly applied for forensic and pathologic examination. However, classical dissection remains dominant in everyday practice. Lack of quantifiable data on the coronary system has become a disadvantageous attribute of traditional autopsy. Therefore, post mortem MSCT angiography was performed in 80 ex corpo hearts with the aim of improving the accuracy and quantitative documentation of pathologic and forensic diagnoses of coronary artery disease (CAD). Hearts were perfused by introducing a new oily or synthetic resin, or using both contrast materials successively. Then the perfused organs were processed for imaging. Detailed angiographic analysis enabled us to localize, map and quantify coronary calcifications, stenoses, and to characterize the types of atherosclerotic plaques. Significant early or late complications of widely used percutaneous coronary interventions (PCI) and coronary bypass surgery (CABS) could be revealed using CT analysis. Furthermore, by using our oily contrast material and CT imaging, we could identify and visualize the clinically important small caliber nodal arteries (diameter 0.4–2.0 mm). The present work suggests that post mortem CT angiography and post-processing of the data may improve the quality of pathologic and forensic diagnosis. Our collection of coronary casts including digital data are available for further analysis.

  • 1. C. Jackowski S. Bolliger E. Aghayev A. Christe T. Kilchoer B. Aebi T. Périnat R. Dirnhofer M.J. Thali 2006 Reduction of post mortem angiography-induced tissue edema by using polyethylene glycol as a contrast materialdissolver J Forensic Sci 51 1134 1137.

    • Search Google Scholar
    • Export Citation
  • 2. F. Ovcina D. Cemerlic 1997 Clinical importance of intramural blood vessels in the sinoatrial segment of the conducting system of the heart Surg Radiol Anat 19 359 363.

    • Search Google Scholar
    • Export Citation
  • 3. G. Abuin A. Nieponice S. Martinez C. Fernando 2000 The role of atrial vessels in aortic root and mitral valve operations Ann Thorac Surg 70 4 1234 1237.

    • Search Google Scholar
    • Export Citation
  • 4. F. Saremi A. Abolhoda O. Ashikyan M.C. Jeffery N. Jagat G.V. Swaminatha K. Khushboo R. Aidan 2008 Arterial supply to sinoatrial and atrioventricular nodes: Imaging with Multidetector CT Radiology 246 99 107.

    • Search Google Scholar
    • Export Citation
  • 5. M. Barry 2003 Medical progress: Sudden death in young athletes N Engl J Med 349 1 20.

  • 6. P. Angelini 2007 Coronary artery anomalies: An entity in search of an identity Circulation 115 1296 1305.

  • 7. M. Von Ludinghausen 1975 Das verteilungs-muster der coronararterien und ihr einbau in das myokard. Ein beitrag zur. Funktionellen Anatomie der Herzkranzgefässe Dtsch Med Wochenschr. 100 2448 2451.

    • Search Google Scholar
    • Export Citation
  • 8. M. Loukas S. Bilinsky E. Bilinsky M. Petru R.H. Anderson 2009 The clinical anatomy of the coronary collateral circulation Clinical Anatomy 2 146 160.

    • Search Google Scholar
    • Export Citation
  • 9. S.M. Weman U.S. Salminen A. Penttilä A. Männikkö P.J. Karhunen 1999 Post mortem cast angiography in the diagnostics of graft complications in patients with fatal outcome following coronary artery bypass grafting (CABG) Int J Legal Med 112 107 114.

    • Search Google Scholar
    • Export Citation
  • 10. K. Törő M. Kiss V. Szarvas Nemeskéri I. Kristóf L. Magyar Keller 2007 Post mortem introduction of corrosion cast method after coronary stent implantation Forensic Science International 171 208 211.

    • Search Google Scholar
    • Export Citation
  • 11. A.S. Agatston W.R. Janowitz F.J. Hildner N.R. Zusmer M. Viamonte Jr. R. Detrano 1990 Quantification of coronary artery calcium using ultrafast computed tomography J Am Coll Cardiol 15 827 832.

    • Search Google Scholar
    • Export Citation
  • 12. B.R. Rah R.J. Katz A.G. Wasserman J.S. Reiner 2001 Post mortem three-dimensional reconstruction of the entire coronary arterial circulation using electron-beam computed tomography Circulation 104 3168.

    • Search Google Scholar
    • Export Citation
  • 13. K.J. Pfeifer U. Klein C.H. Chaussy C. Hammer K. Pielsticker H. Haendle J. Lissner 1974 Postmortale Nierenvergrößerungsangiographie mit fettlöslichem Kontrastmittel Fortschr Röntgenstr 121 472 476.

    • Search Google Scholar
    • Export Citation
  • 14. S. Kralev T.C. Poerner D. Basorth S. Lang C. Wolpert D. Haghi M. Borggrefe K.K. Haase T. Süselbeck 2006 Sidebranch occlusion after coronary stent implantation in patients presenting with ST-elevation myocardial infarction: Clinical impact and angigraphic predictors Am Heart J 151 153 157.

    • Search Google Scholar
    • Export Citation
  • 15. T. Timurkaynak H. Ciftci M. Ozdemir A. Cengel Y. Tavil M. Kaya G. Erdem M. Cemri O. Dortlemez H. Dortlemez 2002 Sidebranch occlusion after coronary stenting with or without balloon predilation: Direct versus conventional stenting J Invasive Cardiology 14 9 497 501.

    • Search Google Scholar
    • Export Citation
  • 16. H. Yilmaz I. Demir A. Belgi M. Kabukcu S. Yalcinkaya O. Sancaktar 2001 Sidebranch occlusion in direct intracoronary stenting: predictors and results Journal of Invasive Cardiology 13 578 581.

    • Search Google Scholar
    • Export Citation
  • 17. W. Mazur W.C. Grinstead A.H. Hakim S.F. Dabaghi J.M. Abukhalil N.M. Ali J. Joseph B.A. French A.E. Raizner 1994 Fate of sidebranches after intracoronary implantation of the Gianturco-Roubin Flex-Stent for acute or threatened closure after percutaneous transluminal coronary angioplasty Am J Cardiol 74 1207 1210.

    • Search Google Scholar
    • Export Citation
  • 18. M. Kotoku A. Tamura N.S.J. Kadota 2007 Sinus arrest caused by occlusion of the sinus node artery during percutaneous coronary intervention for lesions of the proximal right coronary artery Heart Vessels 22 389 92.

    • Search Google Scholar
    • Export Citation
  • 19. D. Berdajs L. Patonay M.I. Turina 2003 The clinical anatomy of the sinus node artery Ann Thorac Surg 76 732 736.

  • 20. D. Berdajs U.P. Schurr A. Wagner B. Seifert M.I. Turina M. Genoni 2008 Incidence and pathophysiology of atrioventricular block following mitral valve replacement and ring annuloplasty European J Cardiothoracic Surgery 34 55 56.

    • Search Google Scholar
    • Export Citation
  • 21. G. Baroldi R. Bigi L. Cortigiani 2005 Ultrasound imaging versus morphopathology in cardiovascular diseases. Coronary collateral circulation and atherosclerotic plaque Cardiovascular Ultrasound 3 6.

    • Search Google Scholar
    • Export Citation
  • 22. E.A. Lo A. Dia A. Ndiaye M.L. Sow 1994 Anatomy of coronary arteries Dakar Medical 39 23 29.

  • 23. P.B. Dobrin D. Hodgett T. Canfield R. Mrkvicka 2001 Mechanical determinants of graft kinking Annals of Vascular Surgery 15 343 349.

    • Search Google Scholar
    • Export Citation
  • 24. C.N.H. Enzweiler T.H. Wiesea J. Peterseina A.E. Lembckea A.C. Borgesc P. Dohmend U. Hoffmann B. Hamma 2003 Diameter changes of occluded venous coronary artery bypass grafts in electron beam tomography: preliminary findings European J Cardio-thoracic Surgery 23 347 353.

    • Search Google Scholar
    • Export Citation
  • 25. S. Goldman K. Zadina T. Moritz T. Ovitt G. Sethi J.G. Copeland L. Thottapurathu B. Krasnicka N. Ellis R.J. Anderson W. Henderson 2004 Long-term patency of saphenous vein and left internal mammary artery grafts after results from a Department of Veterans Affairs Cooperative Study J Am Coll Cardiol 44 2149 2156.

    • Search Google Scholar
    • Export Citation
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2019  
Scimago
H-index
11
Scimago
Journal Rank
0,220
Scimago
Quartile Score
Medicine (miscellaneous) Q3
Scopus
Cite Score
155/133=1,2
Scopus
Cite Score Rank
General Medicine 199/529 (Q2)
Scopus
SNIP
0,343
Scopus
Cites
206
Scopus
Documents
23

 

Interventional Medicine and Applied Science
Language English
Size  
Year of
Foundation
2009
Publication
Programme
changed title
Volumes
per Year
 
Issues
per Year
 
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2061-1617 (Print)
ISSN 2061-5094 (Online)

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