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  • 1 Heart Center, Semmelweis University, Budapest, Hungary
  • 2 Department of Neuroradiology, Universitätsklinikum Würzburg, Würzburg, Germany
  • 3 Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary
  • 4 First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary
  • 5 InSightec Limited, London, Great Britain
  • 6 Department of Radiology, Brigham and Woman's Hospital and Harvard Medical School, Boston, MA, USA
  • 7 Heart Center, Semmelweis University, Határőr út 18, H-1122, Budapest, Hungary
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Abstract

Rationale and Objectives: MR-guided Focused Ultrasound Surgery (MRgFUS) is an evolving thermoablative technique for treatment of benign and malignant soft tissue tumors. The feasibility and effectiveness of this non-invasive method has been tested by several investigators by treating uterine fibroid. The aim of the present study was to evaluate early and mid-term efficacy of MRgFUS treatment using MR imaging follow-ups. Materials and Methods: 38 patients with uterine fibroids were enrolled and treated by MRgFUS in a single center. MRI follow-up exams were performed 3 and 6 months after the procedure. Total fibroid volumes (FV) and non-perfused volumes (NPV) were compared and evaluated over time. Results: There was a significant reduction of FV at 3- and 6-month follow-ups (10±19%, p=0.022 and 19±29%, p<0.001, respectively). In the subgroup of fibroids smaller than 5.4 cm in diameter a 35±18% volume reduction was found after 6 months. There was also a positive correlation found between the early NPV and the FV decrease at 3- and 6-months follow-ups. Conclusion: This study suggests that MRgFUS can effectively coagulate uterine fibroid tissue. Smaller UFs can be most effectively treated within reasonable time with the used equipment.

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