Interventional Medicine and Applied Science
Volume/Issue:
Volume 2: Issue 1
De novo malignant melanoma occurred in renal allograft: DNA typing to determine the origin of the tumour
Authors:
Balázs Nemes Transplantation and Surgical Clinic, Semmelweis University, Budapest, Hungary
Transplantation and Surgical Department, Semmelweis University, Baross u. 23–25, H-1082, Budapest, Hungary

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É. Toronyi Transplantation and Surgical Clinic, Semmelweis University, Budapest, Hungary

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K. Rajczy National Institute of Hematology and Immunology Budapest, Budapest, Hungary

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A. Szakos 1st Institute of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary

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B. Somlai Dermatological Department, Semmelweis University Budapest, Budapest, Hungary

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A. Doros Transplantation and Surgical Clinic, Semmelweis University, Budapest, Hungary

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R. Chmel Transplantation and Surgical Clinic, Semmelweis University, Budapest, Hungary

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F. Derner
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L. Kóbori Transplantation and Surgical Clinic, Semmelweis University, Budapest, Hungary

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Pages:
31–36
Online Publication Date:
01 Mar 2010
Publication Date:
01 Mar 2010
Article Category:
Research Article
DOI:
https://doi.org/10.1556/imas.2.2010.1.7
Keywords:
melanoma; de novo; kidney transplantation; tumour; transmission; DNA; typing
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Abstract

Malignant diseases are considered as great challenges in clinical transplantation. It is well known that the incidence of malignancy is higher in the transplanted population if compared with the normal population. It is important to distinguish between neoplastic diseases originating from pre-existing lesions in the transplanted organs and de novo graft tumours. Post-transplant malignancy of donor origin is a rare complication of organ transplantation, most likely transmitted as micrometastases within the parenchyma of the donor organ or from circulating tumour cells contained within the organ. Malignant melanoma, although its incidence is rather low, is one of the most common donor-derived tumour inadvertently transplanted, comprising 28% of donor transmitted tumours. Malignant melanoma in the graft without dermatological localisation is extremely rare. We report a case of de novo melanoma occurring in the allograft, where transmission from the donor was excluded by DNA (desoxyribonucleic acid) investigation. We did not find any data in the literature where a malignant melanoma occurred after transplantation in the transplanted kidney without any skin lesions and the donor origin was excluded. We draw attention to the importance of the DNA typing in case of tumours occurring in immunosuppressed patients.

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Cover Interventional Medicine and Applied Science
Interventional Medicine and Applied Science
Print ISSN:
2061-1617
Online ISSN:
2061-5094

2019  
Scimago
H-index		 11
Scimago
Journal Rank		 0,220
Scimago
Quartile Score		 Medicine (miscellaneous) Q3
Scopus
Cite Score		 155/133=1,2
Scopus
Cite Score Rank		 General Medicine 199/529 (Q2)
Scopus
SNIP		 0,343
Scopus
Cites		 206
Scopus
Documents		 23

 

Interventional Medicine and Applied Science
Language English
Size  
Year of
Foundation		 2009
Publication
Programme		 changed title
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per Year		  
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per Year		  
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 2061-1617 (Print)
ISSN 2061-5094 (Online)

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