Interventional Medicine and Applied Science
Volume/Issue:
Volume 2: Issue 2
Hepatitis C infected hemodialysis and renal transplant patients with elevated α-glutathione S-transferase have increased risk for liver damage
Authors:
Enikő Sárváry Semmelweis University Transplantation and Surgical Clinic, Budapest, Hungary
Transplantation and Surgical Clinic, Semmelweis University, Baross u. 23–25, H-1082, Budapest, Hungary

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Zs. Gerlei Semmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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E. Dinya EGIS Pharmacenticals LTD., Budapest, Hungary

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E. Tóth EUROCARE Dialysis Center, Békéscsaba, Hungary

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M. Varga Semmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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R. Chmel Semmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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M. Molnar Semmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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A. Remport Semmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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B. Nemes Semmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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L. Kobori Semmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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D. Görög Semmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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J. Fazakas Semmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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I. Gaal Semmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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J. Járay Semmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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F. Perner Semmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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R. Langer Semmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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Pages:
70–76
Online Publication Date:
01 Jun 2010
Publication Date:
01 Jun 2010
Article Category:
Research Article
DOI:
https://doi.org/10.1556/imas.2.2010.2.5
Keywords:
HCV infection; anti-HCV; HCV-PCR; α-glutathione S-transferase; renal transplant; patients on hemodialysis; hepatocellular damage; HCV carriers
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Abstract

Patients on hemodialysis (HD) and renal transplant recipients (RT) have a high prevalence of HCV infection. The aim of our study was to determine the prevalence of HCV-RNA in the anti-HCV positive patients and to compare the biochemical parameters of PCR(+) and PCR(−) subgroups. Methods: The 525 sera were screened for anti-HCV. HCV-RNA was detected by polymerase chain reaction (PCR) and liver enzymes [SGOT, SGPT, GGT, α-glutathione S-transferase (GST)] were measured. Results: Active viraemia was found only in 187 of 289 (65%) seropositive HD patients in contrast to 53 of 53 (100%) of seropositive RT patients. Significantly increased (p<0.05) GST values (9.9 μg/l) were found in the PCR(+) subgroups compared to GST levels (2.7 μg/l) of the PCR(−) subgroups. Elevated GST concentration was found in 80% (208/251) of PCR(+) patients. The measured enzymes were not elevated in HCV infected patients. Six percent of HD and 11% of RT patients were screened before seroconversion. Diagnostic sensitivity (80%) and specificity (79%) of GST were calculated as good for early liver damage caused by HCV. In contrast, the sensitivity of the measurement of other liver enzymes were very weak (SGOT: 8%; SGPT: 10%; GGT: 42%). Conclusion: The significantly higher viraemia of the RT subgroup could be related to the immunosuppressive therapy. Increased GST level may be a useful indicator of tissue damage during HCV infection. If HCV infection is suspected, PCR and GST measurement should be performed, even if anti-HCV result is negative.

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Interventional Medicine and Applied Science
Print ISSN:
2061-1617
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Interventional Medicine and Applied Science
Language English
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