Authors:
Enikő SárvárySemmelweis University Transplantation and Surgical Clinic, Budapest, Hungary
Transplantation and Surgical Clinic, Semmelweis University, Baross u. 23–25, H-1082, Budapest, Hungary

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Zs. GerleiSemmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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E. DinyaEGIS Pharmacenticals LTD., Budapest, Hungary

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E. TóthEUROCARE Dialysis Center, Békéscsaba, Hungary

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M. VargaSemmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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R. ChmelSemmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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M. MolnarSemmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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A. RemportSemmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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B. NemesSemmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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L. KoboriSemmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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D. GörögSemmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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J. FazakasSemmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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I. GaalSemmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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J. JáraySemmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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F. PernerSemmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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R. LangerSemmelweis University Transplantation and Surgical Clinic, Budapest, Hungary

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Abstract

Patients on hemodialysis (HD) and renal transplant recipients (RT) have a high prevalence of HCV infection. The aim of our study was to determine the prevalence of HCV-RNA in the anti-HCV positive patients and to compare the biochemical parameters of PCR(+) and PCR(−) subgroups. Methods: The 525 sera were screened for anti-HCV. HCV-RNA was detected by polymerase chain reaction (PCR) and liver enzymes [SGOT, SGPT, GGT, α-glutathione S-transferase (GST)] were measured. Results: Active viraemia was found only in 187 of 289 (65%) seropositive HD patients in contrast to 53 of 53 (100%) of seropositive RT patients. Significantly increased (p<0.05) GST values (9.9 μg/l) were found in the PCR(+) subgroups compared to GST levels (2.7 μg/l) of the PCR(−) subgroups. Elevated GST concentration was found in 80% (208/251) of PCR(+) patients. The measured enzymes were not elevated in HCV infected patients. Six percent of HD and 11% of RT patients were screened before seroconversion. Diagnostic sensitivity (80%) and specificity (79%) of GST were calculated as good for early liver damage caused by HCV. In contrast, the sensitivity of the measurement of other liver enzymes were very weak (SGOT: 8%; SGPT: 10%; GGT: 42%). Conclusion: The significantly higher viraemia of the RT subgroup could be related to the immunosuppressive therapy. Increased GST level may be a useful indicator of tissue damage during HCV infection. If HCV infection is suspected, PCR and GST measurement should be performed, even if anti-HCV result is negative.

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2019  
Scimago
H-index
11
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0,220
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Medicine (miscellaneous) Q3
Scopus
Cite Score
155/133=1,2
Scopus
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General Medicine 199/529 (Q2)
Scopus
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0,343
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206
Scopus
Documents
23

 

Interventional Medicine and Applied Science
Language English
Size  
Year of
Foundation
2009
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changed title
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per Year
 
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per Year
 
Founder Akadémiai Kiadó
Founder's
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H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
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Chief Executive Officer, Akadémiai Kiadó
ISSN 2061-1617 (Print)
ISSN 2061-5094 (Online)

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