Authors:
H. Vágó Heart Centre, Semmelweis University, Budapest, Hungary

Search for other papers by H. Vágó in
Current site
Google Scholar
PubMed
Close
,
P. Takács Heart Centre, Semmelweis University, Budapest, Hungary

Search for other papers by P. Takács in
Current site
Google Scholar
PubMed
Close
,
A. Tóth Heart Centre, Semmelweis University, Budapest, Hungary

Search for other papers by A. Tóth in
Current site
Google Scholar
PubMed
Close
,
L. Gellér Heart Centre, Semmelweis University, Budapest, Hungary

Search for other papers by L. Gellér in
Current site
Google Scholar
PubMed
Close
,
Sz. Szilágyi Heart Centre, Semmelweis University, Budapest, Hungary

Search for other papers by Sz. Szilágyi in
Current site
Google Scholar
PubMed
Close
,
L. Molnár Heart Centre, Semmelweis University, Budapest, Hungary

Search for other papers by L. Molnár in
Current site
Google Scholar
PubMed
Close
,
V. Kutyifa Heart Centre, Semmelweis University, Budapest, Hungary

Search for other papers by V. Kutyifa in
Current site
Google Scholar
PubMed
Close
,
T. Simor Heart Institute, Faculty of Medicine, University of Pécs, Pécs, Hungary

Search for other papers by T. Simor in
Current site
Google Scholar
PubMed
Close
, and
Béla Merkely Heart Centre, Semmelweis University, Budapest, Hungary
Városmajor u. 68, H-1122, Budapest, Hungary

Search for other papers by Béla Merkely in
Current site
Google Scholar
PubMed
Close
Restricted access

Abstract

Cardiac electromechanical resynchronisation therapy (CRT) is an effective non-pharmacological treatment of patients suffering from drug refractory heart failure. However, approximately 20–30% of patients are non-responder. Cardiac magnetic resonance imaging (CMR) may play significant role in clarifying many questions in this patient population. Forty-five patients, suffering from severe drug refractory heart failure, underwent CMR before applying CRT. Left ventricular end-diastolic, end-systolic volumes, ejection fraction, myocardial mass, wall motion disturbances, localisation of non-viable myocardium were determined. Left ventricular dyssynchrony was determined by illustrating wall-time thickening in short-axis slices of left ventricle from basis to apex. CMR-proved underlying heart disease were postinfarction heart failure, dilated cardiomyopathy and non-compaction cardiomyopathy in 62, 27 and in 11%, respectively. Mean left ventricular ejection fraction was 24.5±10%, intraventricular dyssynchrony was 200±78 ms. In four patients, requiring surgical revascularisation after unsuccessful coronary sinus electrode implantation, optimal position for epicardial screw-in electrode was selected. According to the results of CMR, biventricular device was not implanted in 7 patients. During the follow-up of the 38 patients, 5 patients (13.16%) were non-responders, despite the approximately 22% non-responder ratio in our whole patient population treated by CRT but without performing previous CMR examination. In this patient population CMR may have a significant role in the selection of responder patient population.

  • 1. J.G. Cleland J.C. Daubert E. Erdmann N. Freemantle D. Gras L. Kappenberger L. Tavazzi 2005 Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators: The effect of cardiac resynchronization and mortality in heart failure N Engl J Med 352 1539 1549.

    • Search Google Scholar
    • Export Citation
  • 2. W.T. Abraham W.G. Fisher A.L. Smith D.B. Delurgio A.R. Leon E. Loh D.Z. Kocovic M. Packer A.L. Clavell D.L. Hayes M. Ellestad R.J. Trupp J. Underwood F. Pickering C. Truex P. McAtee J. Messenger MIRACLE Study Group 2002 Multicenter InSync Randomized Clinical Evaluation: Cardiac resynchronization in chronic heart failure N Engl J Med 346 1845 1853.

    • Search Google Scholar
    • Export Citation
  • 3. S. Cazeau C. Leclercq T. Lavergne S. Walker C. Varma C. Linde S. Garrigue L. Kappenberger G.A. Haywood M. Santini C. Bailleul J.C. Daubert 2001 Multisite Stimulation in Cardiomyopathies (MUSTIC) Study Investigators: Effects of multisite biventricular pacing in patients with heart failure and interventricular conduction delay N Engl J Med 344 873 880.

    • Search Google Scholar
    • Export Citation
  • 4. M.I. A. de Roos J.J. Westenberg L.J. Kroft 2008 Imaging techniques in cardiac resynchronization therapy Int J Cardiovasc Imaging 24 89 105.

    • Search Google Scholar
    • Export Citation
  • 5. E.S. Chung A.R. Leon L. Tavazzi J.P. Sun P. Nihoyannopoulos J. Merlino W.T. Abraham S. Ghio C. Leclercq J.J. Bax C.M. Yu J. Gorcsan 3rd M. St John Sutton J. De Sutter J. Murillo 2008 Results of the Predictors of Response to CRT (PROSPECT) trial Circulation 117 2608 2616.

    • Search Google Scholar
    • Export Citation
  • 6. R.H. Helm A.C. Lardo 2008 Cardiac magnetic resonance assessment of mechanical dyssynchrony Current Opinion in Cardiology 23 440 446.

    • Search Google Scholar
    • Export Citation
  • 7. J.A. White R. Yee X. Yuan A. Krahn A. Skanes M. Parker G. Klein M. Drangova 2006 Delayed enhancement magnetic resonance imaging predicts response to cardiac resynchronization therapy in patients with intraventricular dyssynchrony J Am Coll Cardiol 48 1953 1960.

    • Search Google Scholar
    • Export Citation
  • 8. P. Hunold T. Schlosser F.M. Vogt H. Eggebrecht A. Schmermund O. Bruder W.O. Schüler J. Barkhausen 2005 Myocardial late enhancement in contrast-enhanced cardiac MRI: Distinction between infarction scar and non-infarcted-related disease Am J Roentgenol 184 1420 1426.

    • Search Google Scholar
    • Export Citation
  • 9. G.B. Bleeker T.A. Kaandorp H.J. Lamb E. Boersma P. Steendijk A. de Roos E.E. van derWall M.J. Schalij J.J. Bax 2006 Effect of posterolateral scar tissue on clinical and echocardiographic improvement after cardiac resynchronization therapy Circulation 113 969 976.

    • Search Google Scholar
    • Export Citation
  • 10. S. Chalil P.W. Foley S.A. Muyhaldeen K.C. Patel Z.R. Yousef R.E. Smith M.P. Frenneaux F. Leyva 2007 Late gadolinium enhancement-cardiovascular magnetic resonance as a predictor of response to cardiac resynchronization therapy in patients with ischaemic cardiomyopathy Europace 9 1031 1037.

    • Search Google Scholar
    • Export Citation
  • 11. R. Nezafat Y. Han D.C. Peters D.A. Herzka J.V. Wylie B. Goddu K.K. Kissinger S.B. Yeon P.J. Zimetbaum W.J. Manning 2007 Coronary magnetic resonance vein imaging: Imaging contrast, sequence, and timing Magnetic Resonance in Medicine 58 1196 1206.

    • Search Google Scholar
    • Export Citation
  • 12. A. Chiribiri S. Kelle S. Götze C. Kriatselis T. Thouet T. Tangcharoen I. Paetsch B. Schnackenburg E. Fleck E. Nagel 2008 Visualization of the cardiac venous system using cardiac magnetic resonance Am J Cardiol 101 407 412.

    • Search Google Scholar
    • Export Citation
  • Collapse
  • Expand

2019  
Scimago
H-index
11
Scimago
Journal Rank
0,220
Scimago
Quartile Score
Medicine (miscellaneous) Q3
Scopus
Cite Score
155/133=1,2
Scopus
Cite Score Rank
General Medicine 199/529 (Q2)
Scopus
SNIP
0,343
Scopus
Cites
206
Scopus
Documents
23

 

Interventional Medicine and Applied Science
Language English
Size  
Year of
Foundation
2009
Publication
Programme
changed title
Volumes
per Year
 
Issues
per Year
 
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2061-1617 (Print)
ISSN 2061-5094 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Nov 2024 31 0 0
Dec 2024 22 0 0
Jan 2025 20 0 0
Feb 2025 37 0 0
Mar 2025 26 0 0
Apr 2025 24 0 0
May 2025 0 0 0