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E. Gyurkovics 1st Department of Surgery, Semmelweis University, Budapest, Hungary

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P. Arányi 1st Department of Surgery, Semmelweis University, Budapest, Hungary

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Zs. Turóczi 1st Department of Surgery, Semmelweis University, Budapest, Hungary

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D. Garbaisz 1st Department of Surgery, Semmelweis University, Budapest, Hungary

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M. Varga 1st Department of Surgery, Semmelweis University, Budapest, Hungary

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V. Hegedüs 1st Department of Surgery, Semmelweis University, Budapest, Hungary

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G. Lotz 2nd Department of Pathology, Semmelweis University, Budapest, Hungary

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P. Kupcsulik 1st Department of Surgery, Semmelweis University, Budapest, Hungary

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A. Szijártó 1st Department of Surgery, Semmelweis University, Budapest, Hungary
1st Department of Surgery, Semmelweis University, Üllői út 78, H-1082, Budapest, Hungary

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Abstract

Introduction

External aortic compression due to acute gastric dilation is a rare etiology of the lower limb ischemia. This phenomenon leads the author to design experimental study for reperfusion syndrome. The lower limb ischemia-reperfusion (IR) injury consists of local and systemic components called the reperfusion syndrome. It can progrediate into a multi-organ failure which defines postoperative survival. A postconditioning is a surgical technique, which has a potential to reduce IR injury, therefore to prohibit the development of reperfusion syndrome.

Aim

XXXto examine on an experimental model, whether postonditioning is a practicable technique in infarenal aortic surgeries.

Materials and Methods

Male Wistar rats underwent 180 minutes of infrarenal aortic occlusion with 4, 24 and 72 hours of reperfusion. Postconditioning (10 sec. reocclusion / 10 sec. perfusion in 6 cycles) was applied in one group of each reperfusion time. Blood, urine, and histological (muscle, lung, kidney and liver) samples were collected at the postischemic 4th, 24th, and 72th hour.

Results

The early inflammatory response (TNFa, free radicals) and late local inflammation were reduced by posctonditioning significantly. Postconditioning was able to reduce the remote organ injury of lungs and kidneys, the morphological and laboratorial results showed significant difference between the postconditioning and the control group in these two organs. The method's positive effect on remote organ injury remained long-term.

Conclusion

Postconditioning seems to be an applicable process to reduce both local inflammatory and systemic complications of IR injury following vascular surgeries.

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2019  
Scimago
H-index
11
Scimago
Journal Rank
0,220
Scimago
Quartile Score
Medicine (miscellaneous) Q3
Scopus
Cite Score
155/133=1,2
Scopus
Cite Score Rank
General Medicine 199/529 (Q2)
Scopus
SNIP
0,343
Scopus
Cites
206
Scopus
Documents
23

 

Interventional Medicine and Applied Science
Language English
Size  
Year of
Foundation
2009
Publication
Programme
changed title
Volumes
per Year
 
Issues
per Year
 
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2061-1617 (Print)
ISSN 2061-5094 (Online)

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