Interventional Medicine and Applied Science
Volume/Issue:
Volume 4: Issue 1
Evaluation of zinc and selenium alterations in children with acute infections: Correlation with markers of inflammation
Authors:
Theodoros Karakonstantakis Department of Clinical Biochemistry, “Aghia Sophia” Children's Hospital, Athens, 11527, Greece

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Ioannis Papassotiriou Department of Clinical Biochemistry, “Aghia Sophia” Children's Hospital, Athens, 11527, Greece

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Athanassia Sergounioti Department of Clinical Biochemistry, “Aghia Sophia” Children's Hospital, Athens, 11527, Greece

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Panayiotis Moraitis First Department of Pediatrics, Athens University Medical School, Athens, Greece

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Kalliopi Theodoridou Department of Clinical Biochemistry, “Aghia Sophia” Children's Hospital, Athens, 11527, Greece

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Despoina Afordakou Department of Clinical Biochemistry, “Aghia Sophia” Children's Hospital, Athens, 11527, Greece

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Maria Giannaki Department of Microbiology, “Aghia Sophia” Children's Hospital, Athens, Greece

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Maria Theodoridou First Department of Pediatrics, Athens University Medical School, Athens, Greece

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Pages:
15–20
Online Publication Date:
01 Mar 2012
Publication Date:
01 Mar 2012
Article Category:
Research Article
DOI:
https://doi.org/10.1556/imas.4.2012.1.4
Restricted access

Abstract

Objectives: To investigate and assess selenium (Se) and zinc (Zn) serum alterations in children with acute infections. Material and Methods: We determined Se, Zn, C-reactive protein (CRP), serum amyloid A (SAA), and procalcitonin (PCT) in 80 children hospitalized with acute infections. The patients were divided in two groups: Bacterial infections: 40 children (mean age 4.8 years); viral infections: 40 children (mean age 5.7 years). Morning blood samples were collected from each patient in three different periods: (a) in the acute phase (admission), (b) during the inflammatory process (4th day of hospitalization), and (c) after recovery (28–33 days after the first sampling). Results: We found that patients with bacterial infections had significantly lower levels of Se (48.9±16.4 mg/L vs. 58.1±13.7 mg/L, p=0.014) and Zn (69.3±19.4 mg/dL vs. 79.9±13.1 mg/dL, p=0.008) than those with viral infections on admission. Zn and Se levels were significantly increased after remission and the 4th day of hospitalization in patients with bacterial infections. Se and Zn were inversely related with the inflammatory markers CRP (r=−0.480, p=0.002 and r=−0.380, p=0.02, respectively), and PCT (r=−0.670, p < 0.001 and r=−0.510, p<0.01, respectively), in the same patients group on admission. We also found a positive correlation between the two micronutrients (r = 0.400, p<0.01) in children with bacterial infections on admission. Conclusions: Zn and Se behave as negative acute phase reactants and their levels were inversely associated with the progress of infection in patients with bacterial infections. The changes of micronutrients (Se, Zn) during the inflammatory process are transient and resolve without any dietary intervention.

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Cover Interventional Medicine and Applied Science
Interventional Medicine and Applied Science
Print ISSN:
2061-1617
Online ISSN:
2061-5094

2019  
Scimago
H-index		 11
Scimago
Journal Rank		 0,220
Scimago
Quartile Score		 Medicine (miscellaneous) Q3
Scopus
Cite Score		 155/133=1,2
Scopus
Cite Score Rank		 General Medicine 199/529 (Q2)
Scopus
SNIP		 0,343
Scopus
Cites		 206
Scopus
Documents		 23

 

Interventional Medicine and Applied Science
Language English
Size  
Year of
Foundation		 2009
Publication
Programme		 changed title
Volumes
per Year		  
Issues
per Year		  
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 2061-1617 (Print)
ISSN 2061-5094 (Online)

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