Interventional Medicine and Applied Science
Volume/Issue:
Volume 4: Issue 1
Myocilin levels in the aqueous humor of open-angle glaucoma patients
Authors:
Asaad A. Ghanem Department of Ophthalmology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

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Hatem E. El-Awady Department of Ophthalmology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

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Roger C. W. Wolfs Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands

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Lmiaa F. Arafa Department of Medical Biochemistry, Faculty of Medicine, Mansoura University, Mansoura, Egypt

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Pages:
42–47
Online Publication Date:
01 Mar 2012
Publication Date:
01 Mar 2012
Article Category:
Research Article
DOI:
https://doi.org/10.1556/imas.4.2012.1.7
Restricted access

Abstract

Purpose: To investigate the concentration of myocilin in the aqueous humor of open-angle glaucoma (OAG) patients, including correlations with glaucoma subtypes and intraocular pressure (IOP). Patients and Methods: The study comprised 85 patients with OAG. Glaucoma subtypes included 35 cases of high tension glaucoma (HTG), 25 cases of normal tension glaucoma (NTG), and 25 cases of exfoliation glaucoma (ExG). Forty-five patients with senile cataract were included as control. The concentrations of myocilin in the aqueous humor were measured by plotting the densitometry readings of the aqueous humor samples against a recombinant myocilin standard curve. Additionally, the relationships with the glaucoma subtypes, IOP, and glaucoma severity were analyzed. Results: A significantly higher percentage of patients in the glaucoma subgroups were positive for myocilin compared with the cataract group. The mean myocilin concentrations among the glaucoma positive case subgroups were not different (P=0.326). Myocilin levels were significantly higher in human HTG compared with cataract group (P<0.05). There were no significant correlations between the myocilin concentration and the IOP or the severity of glaucoma. Conclusion: Myocilin-positive patients were significant in the glaucoma subgroups than in the cataract group, with a highly significant difference observed for HTG patients.

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Cover Interventional Medicine and Applied Science
Interventional Medicine and Applied Science
Print ISSN:
2061-1617
Online ISSN:
2061-5094

2019  
Scimago
H-index		 11
Scimago
Journal Rank		 0,220
Scimago
Quartile Score		 Medicine (miscellaneous) Q3
Scopus
Cite Score		 155/133=1,2
Scopus
Cite Score Rank		 General Medicine 199/529 (Q2)
Scopus
SNIP		 0,343
Scopus
Cites		 206
Scopus
Documents		 23

 

Interventional Medicine and Applied Science
Language English
Size  
Year of
Foundation		 2009
Publication
Programme		 changed title
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per Year		  
Issues
per Year		  
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 2061-1617 (Print)
ISSN 2061-5094 (Online)

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