Interventional Medicine and Applied Science
Volume/Issue:
Volume 5: Issue 2
MARS therapy, the bridging to liver retransplantation — Three cases from the Hungarian liver transplant program
Authors:
Balázs Pőcze Clinic of Transplantation and Surgery, Semmelweis University, Budapest, Hungary
Clinic of Transplantation and Surgery, Semmelweis University, Baross u. 23–25, H-1083, Budapest, Hungary

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János Fazakas Clinic of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Gergely Zádori Clinic of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Dénes Görög Clinic of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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László Kóbori Clinic of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Eszter Dabasi Clinic of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Tamás Mándli Clinic of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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László Piros Clinic of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Anikó Smudla Clinic of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Tamás Szabó Clinic of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Éva Toronyi Clinic of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Szabolcs Tóth Clinic of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Gellért Tőzsér Clinic of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Gyula Végső Clinic of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Attila Doros Clinic of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Balázs Nemes Clinic of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Pages:
70–75
Online Publication Date:
01 Jun 2013
Publication Date:
01 Jun 2013
Article Category:
Research Article
DOI:
https://doi.org/10.1556/imas.5.2013.2.3
Keywords:
liver failure; MARS therapy; retransplantation
Restricted access

Abstract

Besides orthotopic liver transplantation (OLT) there is no long-term and effective replacement therapy for severe liver failure. Artificial extracorporeal liver supply devices are able to reduce blood toxin levels, but do not replace any synthetic function of the liver. Molecular adsorbent recirculating system (MARS) is one of the methods that can be used to treat fulminant acute liver failure (ALF) or acute on chronic liver failure (AoCLF). The primary non-function (PNF) of the newly transplanted liver manifests in the clinical settings exactly like acute liver failure. MARS treatment can reduce the severity of complications by eliminating blood toxins, so that it can help hepatic encephalopathy (HE), hepatorenal syndrome (HRS), and the high rate mortality of cerebral herniation. This might serve as a bridging therapy before orthotopic liver retransplantation (reOLT). Three patients after a first liver transplantation became candidate for urgent MARS treatment as a bridging solution prior to reOLT in our center. Authors report these three cases, focusing on indications, MARS sessions, clinical courses, and final outcomes.

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  • 18. R. Gaspari F. Cavaliere L. Sollazzi V. Perilli I. Melchionda S. Agnes A. Gasbarrini A.W. Avolio 2009 Molecular Adsorbent Recirculating System (MARS) in patients with primary nonfunction and other causes of graft dysfunction after liver transplantation in the era of extended donor criteria Transplant Proc 41 253 258.

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  • 19. Y.H. Liu Y. Wang L.X. Yu L.Y. Sun B.L. Feng Z.Y. Shen M.M. Wang 2004 Artificial liver support molecular adsorbents recirculating system therapy as a bridge to re-transplantation in two cases of long anhepatic duration Hepatobiliary Pancreat Dis Int 3 2 316 317.

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  • 20. Y.T. Ding Q.X. Xu Y.D. Qiu Y.J. Yang 2004 Molecular adsorbent recycling system in treating patients with acute liver failure: a bridge to liver transplantation Hepatobiliary Pancreat Dis Int 3 4 508 510.

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  • 21. G. Novelli M. Rossi L. Poli V. Morabito A. Bussotti F. Pugliese F. Ruberto S. Novelli G. Mennini P.B. Berloco 2006 Primary nonfunction: timing retransplantation versus hemodynamic parameters and kidney function Transplant Proc 40 1854 1857.

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Cover Interventional Medicine and Applied Science
Interventional Medicine and Applied Science
Print ISSN:
2061-1617
Online ISSN:
2061-5094

2019  
Scimago
H-index		 11
Scimago
Journal Rank		 0,220
Scimago
Quartile Score		 Medicine (miscellaneous) Q3
Scopus
Cite Score		 155/133=1,2
Scopus
Cite Score Rank		 General Medicine 199/529 (Q2)
Scopus
SNIP		 0,343
Scopus
Cites		 206
Scopus
Documents		 23

 

Interventional Medicine and Applied Science
Language English
Size  
Year of
Foundation		 2009
Publication
Programme		 changed title
Volumes
per Year		  
Issues
per Year		  
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 2061-1617 (Print)
ISSN 2061-5094 (Online)

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