Authors:
Fanni Gelley Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary
Department of Transplantation and Surgery, Semmelweis University, Baross u. 23–25, H-1082, Budapest, Hungary

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Gergely Zádori Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Dénes Görög Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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László Kóbori Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Imre Fehérvári Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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György Gámán Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Zsuzsanna Gerlei Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Péter Nagy 2nd Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary

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Enikő Sárváry Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Balázs Nemes Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Abstract

Introduction

Recurrence of primary sclerosing cholangitis (rPSC) after liver transplantation (OLT) significantly affects longterm graft survival. We aimed to evaluate the incidence of rPSC and clinical data of these patients in Hungary.

Patients and Methods

We retrospectively analyzed data of 511 whole liver transplantations from 1995 to 2011. During the study period, 49 OLTs were performed in 43 adult patients with end-stage PSC (10%).

Results

Out of 49 OLT, 24 cases were excluded, rPSC was diagnosed in six patients (12%). Patients with rPSC had significantly higher mortality (p = 0.009) and graft loss (p = 0.009) in comparison to patients without recurrent disease. Younger recipient age, higher donor BMI was observed in the rPSC group. One patient was diagnosed with de novo IBD, the remaining five patients had worsening IBD activity in the posttransplant period. PreOLT colectomy was performed in 21% of the control and none of the rPSC group. PostOLT colectomy was performed in two rPSC patients due to severe therapy resistant colitis.

Conclusions

Recurrent PSC significantly affects long-term mortality and graft loss. Younger age at OLT, higher donor BMI and severe active IBD may be associated with PSC recurrence. PreOLT total colectomy might have protective effect against rPSC.

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2019  
Scimago
H-index
11
Scimago
Journal Rank
0,220
Scimago
Quartile Score
Medicine (miscellaneous) Q3
Scopus
Cite Score
155/133=1,2
Scopus
Cite Score Rank
General Medicine 199/529 (Q2)
Scopus
SNIP
0,343
Scopus
Cites
206
Scopus
Documents
23

 

Interventional Medicine and Applied Science
Language English
Size  
Year of
Foundation
2009
Publication
Programme
changed title
Volumes
per Year
 
Issues
per Year
 
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2061-1617 (Print)
ISSN 2061-5094 (Online)

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