Interventional Medicine and Applied Science
Volume/Issue:
Volume 6: Issue 1
Recurrence of primary sclerosing cholangitis after liver transplantation — The Hungarian experience
Authors:
Fanni Gelley Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary
Department of Transplantation and Surgery, Semmelweis University, Baross u. 23–25, H-1082, Budapest, Hungary

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Gergely Zádori Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Dénes Görög Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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László Kóbori Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Imre Fehérvári Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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György Gámán Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Zsuzsanna Gerlei Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Péter Nagy 2nd Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary

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Enikő Sárváry Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Balázs Nemes Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary

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Pages:
16–18
Online Publication Date:
01 Mar 2014
Publication Date:
01 Mar 2014
Article Category:
Research Article
DOI:
https://doi.org/10.1556/imas.6.2014.1.2
Keywords:
disease recurrence; inflammatory bowel disease; liver transplantation; primary sclerosing cholangitis
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Abstract

Introduction

Recurrence of primary sclerosing cholangitis (rPSC) after liver transplantation (OLT) significantly affects longterm graft survival. We aimed to evaluate the incidence of rPSC and clinical data of these patients in Hungary.

Patients and Methods

We retrospectively analyzed data of 511 whole liver transplantations from 1995 to 2011. During the study period, 49 OLTs were performed in 43 adult patients with end-stage PSC (10%).

Results

Out of 49 OLT, 24 cases were excluded, rPSC was diagnosed in six patients (12%). Patients with rPSC had significantly higher mortality (p = 0.009) and graft loss (p = 0.009) in comparison to patients without recurrent disease. Younger recipient age, higher donor BMI was observed in the rPSC group. One patient was diagnosed with de novo IBD, the remaining five patients had worsening IBD activity in the posttransplant period. PreOLT colectomy was performed in 21% of the control and none of the rPSC group. PostOLT colectomy was performed in two rPSC patients due to severe therapy resistant colitis.

Conclusions

Recurrent PSC significantly affects long-term mortality and graft loss. Younger age at OLT, higher donor BMI and severe active IBD may be associated with PSC recurrence. PreOLT total colectomy might have protective effect against rPSC.

  • 1. J. Campsen M.A. Zimmerman J.F. Trotter M. Wachs T. Bak T. Steinberg I. Kam 2008 Clinically recurrent primary sclerosing cholangitis following liver transplantation: A time course Liver Transpl 14 181 185.

    • Search Google Scholar
    • Export Citation

  • 2. B. Fosby T.H. Karlsen E. Melum 2012 Recurrence and rejection in liver transplantation for primary sclerosing cholangitis World J Gastroenterol 18 1 1 15.

    • Search Google Scholar
    • Export Citation

  • 3. I.W. Graziadei R.H. Wiesner K.P. Batts P.J. Marotta N.F. LaRusso M.K. Porayko J.E. Hay G.J. Gores M.R. Charlton J. Ludwig J.J. Poterucha J.L. Steers R.A. Krom 1999 Recurrence of primary sclerosing cholangitis following liver transplantation Hepatology 29 4 1050 1056.

    • Search Google Scholar
    • Export Citation

  • 4. A. Vera S. Moledina B. Gunson S. Hubscher D. Mirza S. Olliff J. Neuberger 2002 Risk factors for recurrence of primary sclerosing cholangitis of liver allograft Lancet 360 1943 1944.

    • Search Google Scholar
    • Export Citation

  • 5. U. Khettry A. Keaveny A. Goldar-Najafi W.D. Lewis E.A. Pomfret J.J. Pomposelli R.L. Jenkins F.D. Gordon 2003 Liver transplantation for primary sclerosing cholangitis: a long-term clinicopathologic study Hum Pathol 34 1127 1136.

    • Search Google Scholar
    • Export Citation

  • 6. E. Alabraba P. Nightingale B. Gunson S. Hubscher S. Olliff D. Mirza J. Neuberger 2009 A re-evaluation of the risk factors for the recurrence of primary sclerosing cholangitis in liver allografts Liver Transpl 15 330 340.

    • Search Google Scholar
    • Export Citation

  • 7. F. Gelley P. Miheller A. Péter G. Telkes B. Nemes 2012 Activity of ulcerative colitis before and after liver transplantation in primary sclerosing cholangitis: The Hungarian experience Transplant Proc 44 7 2164 2165.

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  • 8. T.H. Karlsen E. Schrumpf K.M. Boberg 2010 Update on primary sclerosing cholangitis Dig Liver Dis 42 390 400.

  • 9. U. Oldakowska-Jedynak M. Nowak K. Mucha B. Foroncewicz P. Nyckowski K. Zieniewicz B. Ziarkiewicz-Wróblewska W. Patkowski B. Górnicka A. Paczkowska B. Michalowicz T. Pilecki J. Pawlak M. Krawczyk L. Paczek 2006 Recurrence of primary sclerosing cholangitis in patients after liver transplantation Transplant Proc 38 240 243.

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    • Export Citation

  • 10. D.H. Adams B. Eksteen S.M. Curbishley 2008 Immunology of the gut and the liver: a love/hate relationship Gut 57 838 848.

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Cover Interventional Medicine and Applied Science
Interventional Medicine and Applied Science
Print ISSN:
2061-1617
Online ISSN:
2061-5094

2019  
Scimago
H-index		 11
Scimago
Journal Rank		 0,220
Scimago
Quartile Score		 Medicine (miscellaneous) Q3
Scopus
Cite Score		 155/133=1,2
Scopus
Cite Score Rank		 General Medicine 199/529 (Q2)
Scopus
SNIP		 0,343
Scopus
Cites		 206
Scopus
Documents		 23

 

Interventional Medicine and Applied Science
Language English
Size  
Year of
Foundation		 2009
Publication
Programme		 changed title
Volumes
per Year		  
Issues
per Year		  
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 2061-1617 (Print)
ISSN 2061-5094 (Online)

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