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  • 1 Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, Graz, A-8010, Austria
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Abstract

In this section of the journal, the continuous flow chemistry literature of the preceding months is presented. Some key examples are highlighted in the form of graphical abstracts. The remaining publications in the field are then listed grouped by journal name, with review articles grouped at the end.

  • Reusable and durable immobilized-cationic gold(I) catalysts for environmentally benign bond-forming reactionsM. Egi, K. Azechi, S. Akai* Advanced Synthesis & Catalysis 2011, 353, 287290.

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  • Solid acids as heterogeneous support for primary amino acid-derived diamines in direct asymmetric aldol reactionsA. L. W. Demuynck, L. Peng, F. de Clippel, J. Vanderleyden, P. A. Jacobs, B. F. Selsa * Advanced Synthesis & Catalysis 2011, 353, 725732.

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  • From batch to continuous flow processing in chemicals manufacturingG. S. Calabrese, S. Pissavini AIChE Journal 2011, 5, 828834.

  • Self-optimizing continuous reactions in supercritical carbon dioxideA. J. Parrott, R. A. Bourne, G. R. Akien, D. J. Irvine,* M. Poliakoff* Angewandte Chemie International Edition 2011, 50, 37883792.

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  • Enantioselective hydrogenation of dimethyl itaconate with immobilised rhodium-duphos complex in a recirculating fixed-bed reactorM. A. Al Herz, A. N. Tsoligkas, M. J. H. Simmons,* J. Wood Applied Catalysis A: General 2011, 396, 148158.

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  • Towards an industrial synthesis of diaminodiphenyl methane (DADPM) using novel delaminated materials: A breakthrough step in the production of isocyanates for polyurethanesP. Botella, A. Corma,* R. H. Carr, C. J. Mitchell Applied Catalysis A: General 2011, 398, 143149.

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  • Probing the energy efficiency of microwave heating and continuous-flow conventional heating as tools for organic chemistryW. G. Devine, N. E. Leadbeater * ARKIVOC 2011, (v), 127143.

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  • Synthesis and biological evaluation of 1,4-benzodiazepin-2-oneswith antitrypanosomal activityJ. Spencer,* R. P. Rathnam, A. L. Harvey, C. J. Clements, R. L. Clark, M. P. Barrett, P. E. Wong, L. Male, S. J. Coles, S. P. Mackay Bioorganic & Medicinal Chemistry 2011, 19, 18021815.

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  • Continuous hydrolysis of pullulan using covalently immobilized pullulanase in a packed bed reactorR. S. Singh,* G. K. Saini, J. F. Kennedy Carbohydrate Polymers, 2011, 83, 672675.

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  • Continuous flow carbamoylation of aniline by dimethyl carbonate using a microreactor coated with a thin film of ceria supported gold nanoparticlesR. Juárez, H. Pennemann, H. García* Catalysis Today 2011, 159, 2528.

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  • Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediatesA. G. OBrien, F. Lévesque, P. H. Seeberger * Chemical Communications 2011, 47, 26882690.

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  • Sonogashira C–C coupling reaction in water using tubular reactors with catalytic metal inner surfaceR. Javaid, H. Kawanami,* M. Chatterjee, T. Ishizaka, A. Suzuki, T. M. Suzuki,* Chemical Engineering Journal 2011, 167, 431435.

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  • Synthesis of polypyridine derivatives using alumina supported gold nanoparticles under micro continuous flow conditionsL. Abahmane, A. Knauer, J. M. Köhler, G. A. Gro ß* Chemical Engineering Journal 2011, 167, 519526.

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  • Production of deuterium labeled (-)-epicatechin in a microreactorJ. W. Betts, S. P. Kitney, Y. Fu, W.-M. Peng, S. M. Kelly, S. J. Haswell * Chemical Engineering Journal 2011, 167, 545547.

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  • Anionic polymerization of alkyl methacrylates using flow microreactor systemsA. Nagaki, A. Miyazaki, Y. Tomida, J.-i. Yoshida * Chemical Engineering Journal 2011, 167, 548555.

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  • Continuous flow azide formation: Optimization and scale-upM. M. E. Delville, P. J. Nieuwland, P. Janssen, K. Koch, J. C. M. van Hest, F. P. J. T. Rutjes * Chemical Engineering Journal 2011, 167, 556559.

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  • Microflow photo-radical chlorination of cycloalkanesH. Matsubara,* Y. Hino, M. Tokizane, I. Ryu* Chemical Engineering Journal 2011, 167, 567571.

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  • Highly selective non-catalytic Claisen rearrangement in a high-pressure and high-temperature water microreaction systemH. Kawanami,* M. Sato, M. Chatterjee, N. Otabe, T. Tuji, Y. Ikushima, T. Ishizaka, T. Yokoyama, T. M. Suzuki Chemical Engineering Journal 2011, 167, 572577.

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  • “Liquid phase catalytic hydrodechlorination of 2,4-dichlorophenol over Pd/Al2O3: Batch vs. continuous operation” S. Gómez-Quero, F. Cárdenas-Lizana, M. A. Keane* Chemical Engineering Journal 2011, 166, 10441051.

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  • A breakthrough method for the accurate addition of reagents in multi-step segmented flow processingH. Lange, C. F. Carter, M. D. Hopkin, A. Burke, J. G. Goode, I. R. Baxendale, S. V. Ley * Chemical Science 2011, 2, 765769.

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  • Palladium-catalyzed amination reactions in flow: overcoming the challenges of clogging via acoustic irradiationT. Noël, J. R. Naber, R. L. Hartman, J. P. McMullen, K. F. Jensen,* S. L. Buchwald * Chemical Science 2011, 2, 287290.

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  • Rapid carbon-11 radiolabelling for PET using microfluidicsP. W. Miller,* H. Audrain, D. Bender, A. J. deMello, A. D. Gee, N. J. Long, R. Vilar Chemistry – A European Journal 2011, 17, 460463.

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  • Inductive heating with magnetic materials inside flow reactorsS. Ceylan, L. Coutable, J. Wegner, A. Kirschning* Chemistry – A European Journal 2011, 17, 18841893.

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  • Gold-nanoparticle-catalyzed synthesis of propargylamines: the traditional A3-multicomponent reaction performed as a two-step flow processL. Abahmane, J. M. Köhler, G. A. Gro ß* Chemistry – A European Journal 2011, 17, 30053010.

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  • Diastereoselective chain-elongation reactions using microreactors for applications in complex molecule assemblyC. F. Carter, H. Lange, D. Sakai, I. R. Baxendale, S. V. Ley * Chemistry – A European Journal 2011, 17, 33983405.

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  • The lab of the future - the importance of remote monitoring and controlM. D. Hopkin,* I. R. Baxendale, S. V. Ley Chemistry Today 2011, 29 (1), 2832.

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  • Mastering ozonolysis: production from laboratory to ton scale in continuous flowM. Nobis, D. M. Roberge Chemistry Today 2011, 29 (1), 5658.

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  • Ozonolysis, the green oxidationM. Exner,* H. Plium, P. Dyer-Smith Chemistry Today 2011, 29 (1), 5961.

  • Continuous synthesis of tert-butyl peroxypivalate using a single-channel microreactor equipped with orifices as emulsification unitsT. Illg,* V. Hessel, P. Löb, J. C. Schouten ChemSusChem 2011, 4, 392398.

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  • Rapid formation of b-allyl substituted isotetronic acid derivatives via Claisen rearrangement using a microfludic deviceX. P. Ma, Z. M. Li, Q. R. Wang Chinese Chemical Letters 2011, 22, 167170.

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  • Continuous-flow synthesis of an efficient methanofullerene acceptor for bulk-heterojunction solar cellsE. Rossi, T. Carofiglio, A. Venturi, A. Ndobe, M. Muccini,* M. Maggini* Energy & Environmental Science 2011, 4, 725727.

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  • “Catalytic selective oxidation of propane to acrylic acid in a fixed-bed reactor with an O2-distributor” W. Fang, Q.-j. Ge,* J.-f. Yu, H.-y. Xu * Industrial & Engineering Chemistry Research 2011, 50, 19621967.

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  • Preparation of cisplatin using microwave heating and continuous-flow processing as toolsE. A. Pedrick, N. E. Leadbeater * Inorganic Chemistry Communications 2011, 14, 481483.

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  • Continuous flow enzyme-catalyzed polymerization in a microreactorS. Kundu, A. S. Bhangale, W. E. Wallace, K. M. Flynn, C. M. Guttman, R. A. Gross,* K. L. Beers Journal of the American Chemical Society 2011, 133, 60066011.

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  • Improved method for kinetic studies in microreactors using flow manipulation and noninvasive Raman spectrometryS. Mozharov, A. Nordon,* D. Littlejohn,* C. Wiles, P. Watts, P. Dallin, J. M. Girkin Journal of the American Chemical Society 2011, 133, 36013608.

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  • Magnetically driven agitation in a tube mixer affords clog-resistant fast mixing independent of linear velocityS. J. Dolman,* J. L. Nyrop, J. T. Kuethe Journal of Organic Chemistry 2011, 76, 993996.

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  • Basic examination of a pilot plant for continuous flow microwave-assisted chemical reaction combined with microreactorsM. Matsuzawa,* S. Togashi, S. Hasebe Journal of Thermal Science and Technology 2011, 6, 6979.

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  • Green benzylation of sodium salicylate by phase-transfer catalysis with third-liquid phase in a continuous two-phase-flow reactorH.-M. Yang,* Y.-S. Huang Journal of the Taiwan Institute of Chemical Engineers 2011, 42, 265270.

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  • Integrated SPPS on continuous-flow radial microfluidic chipW. Wang, Y. Huang, J. Liu, Y. Xie, R. Zhao,* S. Xiong, G. Liu, Y. Chen, H. Ma Lab on a Chip 2011, 11, 929935.

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  • Feasibility of tubular microreactors for emulsion polymerizationA. K. Yadav, J. C. de la Cal, M. J. Barandiaran* Macromolecular Reaction Engineering 2011, 5, 6977.

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  • “Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues” J. T. Hodgkinson, W. R. J. D. Galloway, S. Saraf, I. R. Baxendale, S. V. Ley, M. Ladlow, M. Welch, D. R. Spring* Organic & Biomolecular Chemistry 2011, 9, 5761.

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  • Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagentC. J. Smith, C. D. Smith, N. Nikbin, S. V. Ley, I. R. Baxendale Organic & Biomolecular Chemistry 2011, 9, 19271937.

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  • Continuous flow coupling and decarboxylation reactions promoted by copper tubingY. Zhang, T. F. Jamison, S. Patel,* N. Mainolfi* Organic Letters 2011, 13, 280283.

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  • Safe and reliable synthesis of diazoketones and quinoxalines in a continuous flow reactorL. J. Martin,* A. L. Marzinzik, S. V. Ley, I. R. Baxendale Organic Letters 2011, 13, 320323.

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  • Continuous flow ozonolysis in a laboratory scale reactorM. Irfan, T. N. Glasnov, C. O. Kappe * Organic Letters 2011, 13, 984987.

  • Low pressure ethenolysis of renewable methyl oleate in a microchemical systemC. P. Park, M. M. Van Wingerden, S.- Y. Han, D.-P. Kim,* R. H. Grubbs Organic Letters 2011, 13, 23982401.

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  • The development of continuous process for alkene ozonolysis based on combined in situ FTIR, calorimetry, and computational chemistryA. D. Allian,* S. M. Richter, J. M. Kallemeyn, T. A. Robbins, V. Kishore Organic Process Research & Development 2011, 15, 9197.

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  • Kinetic and scale-up investigations of epoxide aminolysis in microreactors at high temperatures and pressuresN. Zaborenko, M. W. Bedore, T. F. Jamison,* K. F. Jensen * Organic Process Research & Development 2011, 15, 131139.

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  • Development of an early enabling synthesis for PF-03052334-02: a novel hepatoselective HMG-CoA reductase inhibitorD. M. Bowles,* D. C. Boyles, C. Choi, J. A. Pfefferkorn, S. Schuyler Organic Process Research & Development 2011, 15, 148157.

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  • A continuous kilogram-scale process for the manufacture of 7-ethyltryptopholY. Lv, Z. Yu, W. Su* Organic Process Research & Development 2011, 15, 471475.

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  • Rapid determination of reaction kinetics with an automated microfluidic systemJ.P. McMullen, K.F. Jensen* Organic Process Research & Development 2011, 15, 398407.

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  • Catalytic batch and continuous flow production of highly enantioenriched cyclohexane derivatives with polymer-supported diarylprolinol silylethersE. Alza, S. Sayalero, X. C. Cambeiro, R. Martín-Rapún, P. O. Miranda, M. A. Peric às* Synlett 2011, 464468.

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  • “Oxidation reactions in segmented and continuous flow chemical processing using an N-(tert-butyl)phenylsulfinimidoylchloride monolith” H. Lange, M. J. Capener, A. X. Jones, C. J. Smith, N. Nikbin, I. R. Baxendale, S. V. Ley* Synlett 2011, 869873.

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  • “Facile calculation of specific rate constants and activation energies of 18F-fluorination reaction using combined processes of coat-capture-elution and microfluidics” B. Y. Yang, J. M. Jeong,* Y.-S. Lee, D. S. Lee, J.-K. Chung, M. C. Lee Tetrahedron 2011, 67, 24272433.

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  • An approach for continuous-flow processing of reactions that involve the in situ formation of organic productsC. B. Kelly, C. X. Lee, N. E. Leadbeater * Tetrahedron Letters 2011, 67, 263265.

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  • Photosensitized addition of isopropanol to furanones in a continuous-flow dual capillary microreactorA. Yavorskyy, O. Shvydkiv, K. Nolan, N. Hoffmann, M. Oelgemöller* Tetrahedron Letters 2011, 67, 278280.

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  • Toward the optimization of continuous-flow aldol and a-amination reactions by means of proline-functionalized silicon packed-bed microreactorsA. Massi,* A. Cavazzini,* L. Del Zoppo, O. Pandoli, V. Costa, L. Pasti, P. P. Giovannini Tetrahedron Letters 2011, 67, 619622.

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  • Reductive amination of ketones: novel one-step transfer hydrogenations in batch and continuous-flow modeP. Falus, Z. Boros, G. Hornyánszky, J. Nagy, F. Darvas, L. Ürge, L. Poppe* Tetrahedron Letters 2011, 67, 13101312.

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  • Rapid, simple and efficient deprotection of benzyl/benzylidene protected carbohydrates by utilization of flow chemistryF. S. Ekholm, I. M. Mándity, F. Fülöp, * R. Leino* Tetrahedron Letters 2011, 52, 18391841.

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  • Intelligent microflow: development of self-optimizing reaction systemsM. Rasheed, T. Wirth* Angewandte Chemie International Edition 2011, 50, 357358.

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  • Continuous flow organometallic catalysis: new wind in old sailsU. Hintermair, G. Franciò, W. Leitner* Chemical Communications 2011, 47, 36913701.

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  • Ten key issues in modern flow chemistryJ. Wegner, S. Ceylan, A. Kirschning* Chemical Communications 2011, 47, 45834592.

  • Novel process windows – concept, proposition and evaluation methodology, and intensified superheated processingV. Hessel,* Cortese, M. H. J. M. deCroon Chemical Engineering Science 2011, 66, 14261428.

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  • Green and sustainable chemical synthesis using flow microreactorsJ.-i. Yoshida, H. Kim, A. Nagaki ChemSusChem 2011, 4, 331340.

  • Development of microfluidic devices for biomedical and clinical applicationA. Webster, J. Greenman, S. J. Haswell * Journal of Chemical Technology & Biotechnology 2011, 86, 1017.

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  • Fundamentals and applications of immobilized microfluidic enzymatic reactorsS. Matosevic, N. Szita, F. Baganz* Journal of Chemical Technology & Biotechnology 2011, 86, 325334.

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  • Continuous-flow syntheses of heterocyclesT. N. Glasnov, C. O. Kappe * Journal of Heterocyclic Chemistry 2011, 48, 1130.

  • Monolithic flow microreactors improve fine chemicals synthesisA. Sachse, A. Galarneau,* B. Coq, F. Fajula New Journal of Chemistry 2011, 35, 259264.

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