Authors:
Eloïc ColomboLaboratoires Fournier S.A., an Abbott company, Chemical, Design and Synthesis Unit, 50 rue de Dijon, 21310, Daix, France

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Philippe RatelLaboratoires Fournier S.A., an Abbott company, Chemical, Design and Synthesis Unit, 50 rue de Dijon, 21310, Daix, France

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Laurent MounierLaboratoires Fournier S.A., an Abbott company, Chemical, Design and Synthesis Unit, 50 rue de Dijon, 21310, Daix, France

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Fabrice GuillierLaboratoires Fournier S.A., an Abbott company, Chemical, Design and Synthesis Unit, 50 rue de Dijon, 21310, Daix, France

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Abstract

A series of substituted indole-2-carboxylic acid ethyl esters and aza-indole analogs have been prepared using continuous-flow hydrogenation. The identification of some key parameters using a design of experiments (DoE)-based approach allowed efficient optimization of each synthesis. The scale-up study for the multigram preparation of one model indole substrate showed the importance of working at steady state with the H-Cube pparatus. A new useful method for the easy preparation of substituted indoles in various quantities is presented.

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Journal of Flow Chemistry
Language English
Size A4
Year of
Foundation
2011
Volumes
per Year
1
Issues
per Year
4
Founder Áramlásos Kémiai Tudományos Társaság
Founder's
Address
H-1031 Budapest, Hungary Záhony utca 7.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2062-249X (Print)
ISSN 2063-0212 (Online)

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