Reissert Indole Synthesis Using Continuous-Flow Hydrogenation

Eloïc Colombo; Philippe Ratel; Laurent Mounier; Fabrice Guillier

doi:10.1556/jfchem.2011.00009

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Journal of Flow Chemistry

Volume/Issue:: Volume 1: Issue 2

Reissert Indole Synthesis Using Continuous-Flow Hydrogenation

Authors:

Eloïc Colombo

Eloïc Colombo Laboratoires Fournier S.A., an Abbott company, Chemical, Design and Synthesis Unit, 50 rue de Dijon, 21310, Daix, France

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Philippe Ratel

Philippe Ratel Laboratoires Fournier S.A., an Abbott company, Chemical, Design and Synthesis Unit, 50 rue de Dijon, 21310, Daix, France

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Laurent Mounier

Laurent Mounier Laboratoires Fournier S.A., an Abbott company, Chemical, Design and Synthesis Unit, 50 rue de Dijon, 21310, Daix, France

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, and

Fabrice Guillier

Fabrice Guillier Laboratoires Fournier S.A., an Abbott company, Chemical, Design and Synthesis Unit, 50 rue de Dijon, 21310, Daix, France

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Pages:: 68–73

Online Publication Date:: 20 Dec 2011

Publication Date:: 20 Dec 2011

Article Category:: Review Article

DOI:: https://doi.org/10.1556/jfchem.2011.00009

Keywords:: heterogeneous catalysis; reduction; Reissert indole synthesis; heterocycle; design of experiments

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Abstract

A series of substituted indole-2-carboxylic acid ethyl esters and aza-indole analogs have been prepared using continuous-flow hydrogenation. The identification of some key parameters using a design of experiments (DoE)-based approach allowed efficient optimization of each synthesis. The scale-up study for the multigram preparation of one model indole substrate showed the importance of working at steady state with the H-Cube pparatus. A new useful method for the easy preparation of substituted indoles in various quantities is presented.

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Journal of Flow Chemistry A Journal of the Flow Chemistry Society

Print ISSN:: 2062-249X

Online ISSN:: 2063-0212

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Journal of Flow Chemistry
Language	English
Size	A4
Year of Foundation	2011
Volumes per Year	1
Issues per Year	4
Founder	Áramlásos Kémiai Tudományos Társaság
Founder's Address	H-1031 Budapest, Hungary Záhony utca 7.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	2062-249X (Print)
ISSN	2063-0212 (Online)