In this section of the journal, the continuous flow chemistry literature of the preceding months is presented. Some key examples are highlighted in the form of graphical abstracts. The remaining publications in the field are then listed, grouped by journal name, with review articles grouped at the end.
“Miniaturizing biocatalysis: Enzyme-catalyzed reactions in an aqueous/organic segmented flow capillary microreactor” R. Karande, A. Schmid, K. Buehler Advanced Synthesis & Catalysis 2011, 353, 2511–2521.
“Synthesis of a drug-like focused library of trisubstituted pyrrolidines using integrated flow chemistry and batch methods” M. Baumann, I. R. Baxendale, C. Kuratli, S. V. Ley, R. E. Martin, J. Schneider ACS Combinatorial Science 2011, 13, 405–413.
“Continuous-flow synthesis of 3,3-disubstituted oxindoles by a palladium-catalyzed a-arylation/alkylation sequence” P. Li, S. L. Buchwald Angewandte Chemie International Edition 2011, 50, 6396–6400.
“Accelerating palladium-catalyzed C-F bond formation: Use of a microflow packed-bed reactor” T. Nöel, T. J. Maimone, S. L. Buchwald Angewandte Chemie International Edition 2011, 50, 8900–8903.
“Asymmetric organocatalysis and analysis on a single microfluidic nanospray chip” S. Fritzsche, S. Ohla, P. Glaser, D. S. Giera, M. Sickert, C. Schneider, D. Belder Angewandte Chemie International Edition 2011, 50, 9467–9470.
“Chlorination and dehydrochlorination reactions relevant to the manufacture of trichloroethene and tetrachloroethene – Part 1. Reaction pathways” I. W. Sutherland, N. G. Hamilton, C. C. Dudman, P. Jones, D. Lennon, J. M. Winfield Applied Catalysis A: General 2011, 399, 1–11.
“A kinetic study of the liquid-phase hydrogenation of citral on Au/TiO2 and Pt–Sn/TiO2 thin films in capillary microreactors” L. N. Protasova, E. V. Rebrov, H. E. Skelton, A. E. H. Wheatley, J. C. Schouten Applied Catalysis A: General 2011, 399, 12–21.
“Challenging the scope of continuous, gas-phase reactions with supported ionic liquid phase (SILP) catalysts – asymmetric hydrogenation of methyl acetoacetate” E. Öchsner, M. J. Schneider, C. Meyer, M. Haumann, P. Wasserscheid Applied Catalysis A: General 2011, 399, 35–41.
“Multistep reactions using microreactor chemistry” B. Ahmed-Omer, D. A. Barrow, T. Wirth ARKIVOC 2011, (iv), 26–36.
“Unusual behavior in the reactivity of 5-substituted-1 H-tetrazoles in a resistively heated microreactor” B. Gutmann, T. N. Glasnov, T. Razzaq, W. Goessler, D. M. Roberge, C. O. Kappe Beilstein Journal of Organic Chemsitry 2011, 7, 503–517.
“Continuous flow hydrogenation using polysilane-supported palladium/alumina hybrid catalysts” H. Oyamada, T. Naito, S. Kobayashi Beilstein Journal of Organic Chemsitry 2011, 7, 735–739.
“Continuous gas/liquid–liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination” J. R. Breen, G. Sandford, D. S. Yufit, J. A. K. Howard, J. Fray, B. Patel Beilstein Journal of Organic Chemsitry 2011, 7, 1048–1054.
“Microphotochemistry : 4,4¢-dimethoxybenzophenone mediated photodecarboxylation reactions involving phthalimides” O. Shvydkiv, K. Nolan, M. Oelgemöller Beilstein Journal of Organic Chemsitry 2011, 7, 1055–1063.
“Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl3 promoted homocoupling” A. Nagaki, Y. Uesugi, Y. Tomida, J.-i. Yoshida Beilstein Journal of Organic Chemsitry 2011, 7, 1064–1069.
“Continuous flow photolysis of aryl azides: Preparation of 3 H-azepinones” F. R. Bou-Hamdan, F. Lévesque, A. G. O'Brien, P. H. Seeberger Beilstein Journal of Organic Chemsitry 2011, 7, 1124–1129.
“Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis” M. C. Bryan, D. Wernick, C. D. Hein, J. V. Petersen, J. W. Eschelbach, E. M. Doherty Beilstein Journal of Organic Chemsitry 2011, 7, 1141–1149.
“Scaling up of continuous-flow, microwave-assisted, organic reactions by varying the size of Pd-functionalized catalytic monoliths” P. He, S. J. Haswell, P. D. I. Fletcher, S. M. Kelly, A. Mansfield Beilstein Journal of Organic Chemsitry 2011, 7, 1150–1157.
“Triple-channel microreactor for biphasic gas–liquid reactions: Photosensitized oxygenations” R. A. Maurya, C. P. Park, D.-P. Kim Beilstein Journal of Organic Chemsitry 2011, 7, 1158–1163.
“The Eschenmoser coupling reaction under continuous-flow conditions” S. Singh, J. M. Köhler, A. Schober, G. A. Gro ß Beilstein Journal of Organic Chemsitry 2011, 7, 1164–1172.
“Koch–Haaf reaction of adamantanols in an acid-tolerant hastelloy-made microreactor” T. Fukuyama, Y. Mukai, I. Ryu Beilstein Journal of Organic Chemsitry 2011, 7, 1288–1293.
“Internal mass-transfer limitations on the transesterification of coconut oil using an anionic ion exchange resin in a packed bed reactor” C. E. T. Co, M. C. Tan, J. A. R. Diamante, L. R. C. Yan, R. R. Tan, L. F. Razon Catalysis Today 2011, 174, 54–58.
“Heterogeneously catalyzed continuous-flow hydrogenation using segmented flow in capillary columns” J. J. W. Bakker, M. M. P. Zieverink, R. W. E. G. Reintjens, F. Kapteijn, J. A. Moulijn, M. T. Kreutzer ChemCatChem 2011, 3, 1155–1157.
“The continuous-flow cycloaddition of azomethine ylides to carbon nanotubes” P. Salice, P. Maity, E. Rossi, T. Carofiglio, E. Menna, M. Maggini Chemical Communications 2011, 47, 9092–9094.
“Photocatalytic reaction using novel inorganic polymer derived packed bed microreactor with modified TiO2 microbeads” T.-H. Yoon, L.-Y. Hong, D.-P. Kim, Chemical Engineering Journal 2011, 167, 666–670.
“Scale-up concept of single-channel microreactors from process development to industrial production” N. Kockmann, M. Gottsponer, D. M. Roberge Chemical Engineering Journal 2011, 167, 718–726.
“Sicherheitstechnische Untersuchungen zum Betrieb von Mikroreaktoren im Explosionsbereich” H. Hieronymus, J. Fischer, S. Heinrich, C. Liebner, T. Lange, E. Klemm Chemie Ingenieur Technik 2011, 83, 1–7.
“Redispersions-Mikroreaktorsystem für eine phasentransferkatalysierte Veresterung” J. Jovanovic, W. Hengeveld, E. V. Rebrov, T. A. Nijhuis, V. Hessel, J. C. Schouten Chemie Ingenieur Technik 2011, 83, 1096–1106.
“Reverse-flow adsorption for process-integrated recycling of homogeneous transition-metal catalysts” F. Marras, P. W. N. M. van Leeuwen, J. N. H. Reek Chemistry – A European Journal 2011, 17, 7460–771.
“Rapid access to a-alkoxy and a-amino acid derivatives through safe continuous-flow generation of diazoesters” H. E. Bartrum, D. C. Blakemore, C. J. Moody, C. J. Hayes Chemistry – A European Journal 2011, 17, 9586–9589.
“Azide synthesis in microstructured flow systems” M. Weber, G. Yilmaz, G. Wille Chemistry Today 2011, 29, 8–10.
“Continuous-flow production of alkyl nitrites” J.-C. M. Monbaliu, J. Jorda, B. Chevalier, C. V. Stevens, B. Morvan Chemistry Today 2011, 29, 50–52.
“Fast optimisation of a Diels-Alder reaction in a flow microreactor by in-line HPLC analysis” M. Rasheed, T. Wirth Chemistry Today 2011, 29, 54–56.
“Rapid and efficient radiosyntheses of meta-substituted [18F]fluoroarenes from [18F]fluoride ion and diaryliodonium tosylates within a microreactor” J.-H. Chun, S. Lu, V. W. Pike European Journal of Organic Chemistry 2011, 4439–4447.
“Continuous flow synthesis of methanofullerenes in microstructured reactors: A kinetic study” S. Silvestrini, D. D. Nogare, T. Carofiglio, E. Menna, P. Canu, M. Maggini European Journal of Organic Chemistry 2011, 5571–5576.
“Applying a continuous capillary-based process to the synthesis of 3-chloro-2-hydroxypropyl pivaloate” M. Escriba, V. Hessel, S. Rothstock, J. Eras, R. Canela, P. Löb Green Chemistry 2011, 13, 1799–1805.
“Selective aerobic oxidation of para-xylene in sub- and supercritical water. Part 1. Comparison with ortho-xylene and the role of the catalyst” E. Perez, J. Fraga-Dubreuil, E. Garcia-Verdugo, P. A. Hamley, W. B. Thomas, D. Housley, W. Partenheimer, M. Poliakoff Green Chemistry 2011, 13, 2389–2396.
“Selective aerobic oxidation of para-xylene in sub- and supercritical water. Part 2. The discovery of better catalysts” E. Perez, J. Fraga-Dubreuil, E. Garcia-Verdugo, P. A. Hamley, M. L. Thomas, C. Yan, W. B. Thomas, D. Housley, W. Partenheimer, M. Poliakoff Green Chemistry 2011, 13, 2397–2407.
“Microwave-Assisted Process Intensification of Synthesis of Thymol Using Carbonized Sulfonic Acidic Resin (CSA) Catalyst” A. A. Ali, V. G. Gaikar Industrial & Engineering Chemistry Research 2011, 50, 6543–6555.
“Selective hydrogenolysis of polyols and cyclic ethers over bifunctional surface sites on rhodium/rhenium catalysts” M. Chia, Y. J. Pagan-Torres, D. Hibbitts, Q. Tan, H. N. Pham, A. K. Datye, M. Neurock, R. J. Davis, J. A. Dumesic Journal of the American Chemical Society 2011, 133, 12675–12689.
“Ultrafast and continuous synthesis of unaccommodating inorganic nanomaterials in droplet- and ionic liquid-assisted microfluidic system” P. H. Hoang, H. Park, D.-P. Kim Journal of the American Chemical Society 2011, 133, 14765–14770.
“Immobilised enzyme microreactor for screening of multi-step bioconversions: Characterisation of a de novo transketolase-w-transaminase pathway to synthesise chiral amino alcohols” S. Matosevic, G. J. Lye, F. Baganz Journal of Biotechnology 2011, 155, 320–329.
“Microflow systems for chemical synthesis and analysis: Approaches to full integration of chemical process” K. Mawatari, Y. Kazoe, A. Aota, T. Tsukahara, K. Sato, T. Kitamori Journal of Flow Chemistry 2011, 1, 3–12.
“From a review of noble metal versus enzyme catalysts for glucose oxidation under conventional conditions towards a process design analysis for continuous-flow operation” I. Dencic, J. Meuldijk, M. de Croon, V. Hessel Journal of Flow Chemistry 2011, 1, 13–23.
“Scalable and robust synthesis of CpRu(MeCN)3PF6 via continuous flow photochemistry” A. C. Gutierrez, T. F. Jamison Journal of Flow Chemistry 2011, 1, 24–27.
“An automated process for a sequential heterocycle/multicomponent reaction: Multistep continuous flow synthesis of 5-(thiazol-2-yl)-3,4-dihydropyrimidin-2(1H)-ones” N. Pagano, A. Herath, N. D. P. Cosford Journal of Flow Chemistry 2011, 1, 28–31.
“Accessing stereochemically rich sultams via microwave-assisted, continuous-flow organic synthesis (MACOS) scale-out” M. G. Organ, P. R. Hanson, A. Rolfe, T. B. Samarakoon, F. Ullah Journal of Flow Chemistry 2011, 1, 32–39.
“Continuous microflow [2+2] photocycloaddition reactions using energy-saving compact light sources” T. Fukuyama, Y. Kajihara, Y. Hino, I. Ryu Journal of Flow Chemistry 2011, 1, 40–45.
“Diacylglycerol synthesis by lipase-catalyzed partial hydrolysis of palm oil under microwave irradiation and continuous flow conditions” L. M. C. Matos, I. C. R. Leal, R. O. M. A. de Souza, Journal of Molecular Catalysis B: Enzymatic 2011, 72, 36–39.
“Microwave-assisted and continuous flow multistep synthesis of 4-(pyrazol-1-yl)carboxanilides” D. Obermayer, T. N. Glasnov, C. O. Kappe Journal of Organic Chemistry 2011, 76, 6657–6669.
“A Teflon microreactor with integrated piezoelectric actuator to handle solid forming reactions” S. Kuhn, T. Nöel, L. Gu, P. L. Heider, K. F. Jensen Lab on a Chip 2011, 11, 2488–2492.
“Highly selective deuteration of pharmaceutically relevant nitrogen-containing heterocycles: a flow chemistry approach” S. B. Ötvös, I. M. Mandity, F. Fülöp Molecular Diversity 2011, 15, 605–611.
“Stepwise aromatic nucleophilic substitution in continuous flow. Synthesis of an unsymmetrically substituted 3,5-diamino-benzonitrile library” L. Lengyel, V. Gyóllai, T. Nagy, G. Dorman, P. Terleczky, V. Hada, K. Nogradi, F. Sebök, L. Ürge, F. Darvas Molecular Diversity 2011, 15, 631–638.
“Application of continuous flow and alternative energy devices for 5-hydroxymethylfurfural production” M. Schön, M. Schnürch, M. D. Mihovilovic Molecular Diversity 2011, 15, 639–643.
“Continuous-flow reactor-based synthesis of carbohydrate and dihydrolipoic acid-capped quantum dots” P. Laurino, R. Kikkeri, P. H. Seeberger Nature Protocols 2011, 6, 1209–1220.
“Continuous-flow, palladium-catalysed alkoxycarbonylation reactions using a prototype reactor in which it is possible to load gas and heat simultaneously” M. A. Mercadante, N. E. Leadbeater Organic & Biomolecular Chemistry 2011, 9, 6575–6578.
“Teflon AF-2400 mediated gas–liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration” P. Koos, U. Gross, A. Polyzos, M. O'Brien, I. Baxendale, S. V. Ley Organic & Biomolecular Chemistry 2011, 9, 6903–6908.
“A new enabling technology for convenient laboratory scale continuous flow processing at low temperatures” D. L. Browne, M. Baumann, B. H. Harji, I. R. Baxendale, S. V. Ley Organic Letters 2011, 13, 3312–3315.
“Synthesis of 5-iodo-1,2,3-triazole-containing macrocycles using copper flow reactor technology” A. R. Bogdan, K. James Organic Letters 2011, 13, 4060–4063.
“Suzuki-Miyaura cross-coupling of heteroaryl halides and arylboronic acids in continuous flow” T. Nöel, A. J. Musacchio Organic Letters 2011, 13, 5180–5183.
“A general, one-step synthesis of substituted indazoles using a flow reactor” R. C. Wheeler, E. Baxter, I. B. Campbell, S. J. F. Macdonald Organic Process Research & Development 2011, 15, 565–569.
“Phase transfer catalyzed Wittig reaction in the microtube reactor under liquid–liquid slug-flow pattern” E. Sinkovec, M. Krajnc Organic Process Research & Development 2011, 15, 817–823.
“Ozonolysis in Flow Using Capillary Reactors” M. D. Roydhouse, A. Ghaini, A. Constantinou, A. Cantu-Perez, W. B. Motherwell, A. Gavriilidis Organic Process Research & Development 2011, 15, 989–996.
“Microphotochemistry: a reactor comparison study using the photosensitized addition of isopropanol to furanones as a model reaction” O. Shvydkiv, A. Yavorskyy, S. B. Tan, K. Nolan, N. Hoffmann, A. Youssef, M. Oelgemöller Photochemical & Photobiological Sciences 2011, 10, 1399–1404.
“First synthesis of methyl 2-amino-6-methoxynicotinate using a combination of microwave and flow reaction technologies” G. Jeges, T. Meszaros, T. Szommer, J. Kovacs, T. Nagy, D. Tymoshenko, N. Fotouhi, P. Gillespie, A. Kowalczyk, R. A. Goodnow Jr. Synlett 2011, 203–206.
“An integrated flow and batch-based approach for the synthesis of O-methyl siphonazole” M. Baumann, I. R. Baxendale, M. Brasholz, J. J. Hayward, S. V. Ley, N. Nikbin Synlett 2011, 1375–1380.
“Petasis olefination in a continuous-flow microwave reactor: exo-Glycals from sugar lactones” S. Koch, H. Löwe, H. Kunz Synlett 2011, 1978–1982.
“Stereoselective glycosylation of 3-deoxy-d-manno-2-octulosonic acid with batch and microfluidic methods” A. Shimoyama, Y. Fujimoto, K. Fukase Synlett 2011, 2359–2362.
“Application of a double aza-Michael reaction in a ‘Click, Click, Cy-Click’ strategy: From bench to flow” Q. Zang, S. Javed, F. Ullah, A. Zhou, C. A. Knudtson, D. Bi, F. Z. Basha, M. G. Organ, P. R. Hanson Synthesis 2011, 2743–2750.
“Heterogeneous continuous flow synthetic system using cyclohexane-based multiphase electrolyte solutions” Y. Okada, T. Yoshioka, M. Koike, K. Chiba Tetrahedron Letters 2011, 52, 4690–4693.
“Efficient synthesis of unsymmetric diarylalkynes from decarboxylative coupling in a continuous flow reaction system” H. J. Lee, K. Park, G. Bae, J. Choe, K. H. Song, S. Lee Tetrahedron Letters 2011, 52, 5064–5067.
“Ultrasound-promoted intramolecular direct arylation in a capillary flow microreactor” L. Zhang, M. Geng, P. Teng, D. Zhao, X. Lu, J.-X. Li Ultrasonics Sonochemistry 2011, 19, 250–256.
“Deciding whether to go with the flow: evaluating the merits of flow reactors for synthesis” R. L. Hartman, J. P. McMullen, K. F. Jensen Angewandte Chemie International Edition 2011, 50, 7502–7519.
“Efficient and selective chemical transformations under flow conditions: The combination of supported catalysts and supercritical fluids” M. I. Burguete, E. García-Verdugo, S. V. Luis Beilstein Journal of Organic Chemistry 2011, 7, 1347–1359.
“Biotransformations in microstructured reactors: more than flowing with the stream?” J. M. Bolivar, J. Wiesbauer, B. Nidetzky Trends in Biotechnology 2011, 29, 333–342.
“Cross-coupling in flow” T. Nöel, S. L. Buchwald Chemical Society Reviews 2011, 40, 5010–5029.
“Recent advances in micro reaction technology” C. Wiles, P. Watts Chemical Communications 2011, 47, 6512–6535.
“Micromixer-assisted polymerization processes” F. Bally, C. A. Serra, V. Hessel, G. Hadziioannou Chemical Engineering Science 2011, 66, 1449–1462.
“The microwave-to-flow paradigm: translating high-temperature batch microwave chemistry to scalable continuous-flow processes” T. N. Glasnov, C. O. Kappe Chemistry – A European Journal 2011, 17, 11956–11968.
“Microfluidics: An essential tool for product development in the life sciences” H. Becker, C. Gärtner Chemistry Today 2011, 29, 11–14.
“Catalytic processes in small scale flow reactors: Status and opportunities” K. D. Nagy, L. F. Jensen Chemistry Today 2011, 29, 18–21.
“Flow chemistry today: practical approaches for optimization and scale-up” R. Becker, K. Koch, P. J. Nieuwland, F. P. J. T. Rutjes Chemistry Today 2011, 29, 47–49.
“Safe use of azides in continuous flow” A.G. O'Brien, F. Levesque, Y. Suzuki, P. H. Seeberger Chemistry Today 2011, 29, 57–60.
“Novel process windows – Part 1: Boosted micro process technology” V. Hessel, Q. Wang Chemistry Today 2011, 29, 81–84.
“The flow synthesis of heterocycles for natural product and medicinal chemistry applications” M. Baumann, I. R. Baxendale, S. V. Ley Molecular Diversity 2011, 15, 613–630.
“Recent advances in microflow photochemistry” M. Oelgemöller, O. Shvydkiv Molecules 2011, 16, 7522–7550.