Journal of Flow Chemistry
Volume/Issue:
Volume 2: Issue 1
Acyl Azide Synthesis and Curtius Rearrangements in Microstructured Flow Chemistry Systems
Authors: Hanspeter Sprecher 1 , M. Nieves Pérez Payán 1 , Michael Weber 1 , Goekcen Yilmaz 1 , and Gregor Wille 1
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  • 1 Sigma-Aldrich Production GmbH, 9471, Industriestrasse 25, Buchs, Switzerland
DOI:
https://doi.org/10.1556/jfchem.2011.00017
Page Count:
20–23
Publication Date:
21 Mar 2012
Online Publication Date:
21 Mar 2012
Article Category:
Research Article
Restricted access

Abstract

The synthesis and utilisation of acyl azides in a flow apparatus combined with an automated extraction unit is described. This process safely provides multi-100 g quantities of a labile diacyl azide (3) as an intermediate that could not be generated safely by classic batch methods. Its subsequent conversion to the desired amine (4) represents an example for process intensification. The same set-up with an output capacity of >30 g/h was used for the unattended synthesis of benzoyl azide as the final product in solution (tert-butyl methyl ether (TBME), 0.5 M).

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Cover Journal of Flow Chemistry
Journal of Flow Chemistry A Journal of the Flow Chemistry Society
Print ISSN:
2062-249X
Online ISSN:
2063-0212
Keywords:
acyl azide synthesis; Curtius rearrangement; continuous extraction; process safety

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