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  • 1 NiKem Research, 20021, via Zambeletti 25, Milan, Baranzate, Italy
  • 2 Erregierre, San Paolo D'Argon, Bergamo, Italy
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O-Alkylation of phenol compounds was performed in a continuous flow apparatus under biphasic liquid/liquid conditions and promoted by tetrabutylammonium bromide (TBAB) as a phase-transfer catalyst. The segmented flow that is generated within the flow system is able to afford the desired ethers in high yield and in very short times.

Supplementary Materials

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