Journal of Flow Chemistry
Volume/Issue:
Volume 2: Issue 3
Combinatorial Synthesis of Peptidomimetics Using Digital Microfluidics
Authors:
Mais J. Jebrail Department of Chemistry, University of Toronto, Toronto, ON M5S-3H6, Canada

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Naila Assem Department of Chemistry, University of Toronto, Toronto, ON M5S-3H6, Canada

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Jared M. Mudrik Department of Chemistry, University of Toronto, Toronto, ON M5S-3H6, Canada

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Michael D.M. Dryden Department of Chemistry, University of Toronto, Toronto, ON M5S-3H6, Canada

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Kaixiang Lin Department of Chemistry, University of Toronto, Toronto, ON M5S-3H6, Canada

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Andrei K. Yudin Department of Chemistry, University of Toronto, Toronto, ON M5S-3H6, Canada

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Aaron R. Wheeler Department of Chemistry, University of Toronto, Toronto, ON M5S-3H6, Canada

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Pages:
103–107
Online Publication Date:
14 Sep 2012
Publication Date:
14 Sep 2012
Article Category:
Research Article
DOI:
https://doi.org/10.1556/jfc-d-12-00012
Keywords:
digital microfluidics; combinatorial synthesis; peptidomimetics; therapeutics discovery
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Abstract

A microfluidic technique for combinatorial chemical synthesis of peptidomimetics has been developed. The new method is fast, automated and includes an integrated magnetic separation of inorganic catalysts from reaction products. This proof-of-concept study should lead to methods for generating libraries of compounds suitable for screening for bioactivity.

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Cover Journal of Flow Chemistry
Journal of Flow Chemistry A Journal of the Flow Chemistry Society
Print ISSN:
2062-249X
Online ISSN:
2063-0212

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Journal of Flow Chemistry
Language English
Size A4
Year of
Foundation		 2011
Volumes
per Year		 1
Issues
per Year		 4
Founder Áramlásos Kémiai Tudományos Társaság
Founder's
Address		 H-1031 Budapest, Hungary Záhony utca 7.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 2062-249X (Print)
ISSN 2063-0212 (Online)

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