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  • 1 Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, A-8010, Graz, Austria
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Abstract

In this section of the journal, the continuous flow chemistry literature of the preceding months is presented. Included are articles published in the period March–June 2012. Some key examples are highlighted in the form of graphical abstracts. The remaining publications in the field are then listed ordered by journal name, with review articles grouped at the end.

  • Lithiation of 1,2-dichloroethene in flow microreactors: Versatile synthesis of alkenes and alkynes by precise residence-time control” A. Nagaki, C. Matsuo, S. Kim, K. Saito, A. Miyazaki, J.-i. Yoshida*.

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  • A photoflow reactor for the continuous photoredox-mediated synthesis of C-glycoamino acids and C-glycolipidsR. S. Andrews, J. J. Becker, M. R. Gagne* Angewandte Chemie International Edition 2012, 51, 41404143.

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  • An efficient flow-photochemical synthesis of 5 H-furanones leads to an understanding of torquoselectivity in cyclobutenone rearrangementsD. C. Harrowven,* M. Mohamed, T. P. Gon çalves, R. J. Whitby, D. Bolien, H. F. Sneddon Angewandte Chemie International Edition 2012, 51, 44054408.

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  • Enantioselective β-arylation of ketones enabled by lithiation/borylation/1,4-addition sequence under flow conditionsW. Shu, S. L. Buchwald* Angewandte Chemie International Edition 2012, 51, 53555358.

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  • Homogeneous biogenic paramagnetic nanoparticle synthesis based on a microfluidic droplet generatorJ. H. Jung, T. J. Park, S. Y. Lee,* T. S. Seo* Angewandte Chemie International Edition 2012, 51, 56345637.

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  • “Preparation and use of polystyryl-DABCOF2: An efficient recoverable and reusable catalyst for β-azidation of α,β-unsaturated ketones in water” T. Angelini, D. Lanari, R. Maggi, F. Pizzo, G. Sartori, L. Vaccaroa* Advanced Synthesis and Catalysis 2012, 354, 908916.

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  • FT-IR spectroscopic imaging of reactions in multiphase flow in microfluidic channelsK. L. A. Chan, S. G. Kazarian* Analytical Chemistry 2012, 84, 40524056.

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  • Microreactor containing platinum nanoparticles for nitrobenzene hydrogenationS. Kataoka,* Y. Takeuchi, A. Harada, T. Takagi, Y. Takenaka, N. Fukaya, H. Yasuda, T. Ohmori, A. Endo* Applied Catalysis A: General 2012, 427428, 119124.

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  • Non-catalytic heterogeneous biodiesel production via a continuous flow systemE. E. Kwon,* H. Yi, J. Park, J. Seo Bioresource Technology 2012, 114, 370374.

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  • Mass transfer characteristic in the formation stage of gas–liquid segmented flow in microchannelJ. Tan,* Y. C. Lu, J. H. Xu, G. S. Luo* Chemical Engineering Journal 2012, 185186, 314320.

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  • One step synthesis of monodisperse Au–Ag alloy nanoparticles in a microreaction systemL. Suna, W. Luana,* Y. Shanb, S. Tua Chemical Engineering Journal 2012, 189190, 451455.

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  • Turbulent mixing and fast chemical reaction in the confined jet flow at large Schmidt numberA. Chorny,* V. Zhdanov Chemical Engineering Science 2012, 78, 541554.

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  • Continuous flow synthesis of ceria nanoparticles using static T-mixersB. Palanisamy,* B. Paul Chemical Engineering Science 2012, 78, 4652.

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  • Visible-light-mediated photochemistry: Accelerating Ru(bpy)3 2+-catalyzed reactions in continuous flowF. R. Bou-Hamdan, P. H. Seeberger* Chemical Science 2012, 3, 16121616.

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  • Cross-coupling of aryllithiums with aryl and vinyl halides in flow microreactorsA. Nagaki, Y. Moriwaki, S. Haraki, A. Kenmoku, N. Takabayashi, A. Hayashi, J.-i. Yoshida* Chemistry—An Asian Journal 2012, 7, 10611068.

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  • Self-supported chiral titanium cluster (SCTC) as a robust catalyst for the asymmetric cyanation of imines under batch and continuous flow at room temperatureA. M. Seayad,* B. Ramalingam,* C. L. L. Chai, C. Li, M. V. Garland, K. Yoshinaga Chemistry—A European Journal 2012, 18, 56935700.

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  • Copper-catalyzed formation of C–O bonds by direct α-C–H bond activation of ethers using stoichiometric amounts of peroxide in batch and continuous-flow formatsG. S. Kumar, B. Pieber, K. R. Reddy,* C. O. Kappe* Chemistry—A European Journal 2012, 18, 61246128.

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  • “4-(N, N-dimethylamino)pyridine-embedded nanoporous conjugated polymer as a highly active heterogeneous organocatalyst” Y. Zhang, Y. Zhang, Y. L. Sun, X. Du, J. Y. Shi, W. D. Wang, W. Wang* Chemistry—A European Journal 2012, 18, 63286334.

  • Continuous-flow reactor-based enzymatic synthesis of phosphorylated compounds on a large scaleL. Babich, A. F. Hartog, M. A. van der Horst, R. Wever* Chemistry—A European Journal 2012, 18, 66046609.

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  • Online monitoring of vinyl chloride polymerization in a microreactor using Raman spectroscopyM. D. Bodoc, L. Prat,* C. Xuereb, C. Gourdon, T. Lasuye Chemistry Engineering & Technology 2012, 4, 705712.

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  • Scale-up-fähiges equipment für die prozessentwicklungN. Kockmann Chemie Ingenieur Technik 2012, 84, 646659.

  • “Potenzialanalyse von milli- und mikroprozesstechniken für die verkürzung von prozessentwicklungszeiten chemie und prozessdesign als intensivierungsfelder” V. Hessel1,* I. V. Gürsel, Q. Wang, T. Noel, J. Lang Chemie Ingenieur Technik 2012, 84, 660684.

  • Sicherheitsaspekte bei der prozessentwicklung und kleinmengenproduktion mit mikroreaktorenN. Kockmann Chemie Ingenieur Technik 2012, 84, 715726.

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  • Local structure of ZnO micro flowers and nanoparticles obtained by micro-segmented flow synthesisS. Li,* A. Roy, H. Lichtenberg, G. Merchan, C. S. S. R. Kumar, J. M. Köhler ChemPhysChem 2012, 13, 15571561.

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  • “Immobilised lipase on structured supports containing covalently attached ionic liquids for the continuous synthesis of biodiesel in scCO2P. Lozano,* E. Garcia-Verdugo, J. M. Bernal, D. F. Izquierdo, M. I. Burguete, G. Sanchez-Gomez, S. V. Luis* ChemSusChem 2012, 5, 790798.

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  • Application of flow chemistry to the selective reduction of esters to aldehydesJ. de M. Munoz, J. Alcazar,* A. de la Hoz, A. Diaz-Ortiz European Journal of Organic Chemistry 2012, 260263.

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  • Soluble polymer-supported flow synthesis: A green process for the preparation of heterocyclesN. Prosa, R. Turgis, R. Piccardi, M.-C. Scherrmann* European Journal of Organic Chemistry 2012, 21882200.

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  • Photooxygenations in a bubble column reactorA. Yavorskyy, O. Shvydkiv, C. Limburg, K. Nolan, Y. M. C. Delauréc, M. Oelgemöller* Green Chemistry 2012, 14, 888892.

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  • Silica-supported 5-(pyrrolidin-2-yl)tetrazole: Development of organocatalytic processes from batch to continuous-flow conditionsO. Bortolini, L. Caciolli, A. Cavazzini,* V. Costa, R. Greco, A. Massi,* L. Pastib Green Chemistry 2012, 14, 9921000.

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  • Asymmetric hydrogenation of C=C double bonds using Rh-complex under homogeneous, heterogeneous and continuous mode conditionsS. Balogh, G. Farkas, J. Madarasz, A. Szöllosy, J. Kovacs, F. Darvas, L. Ürge, J. Bakos* Green Chemistry 2012, 14, 11461151.

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  • Preparation of amides mediated by isopropylmagnesium chloride under continuous flow conditionsJ. de M. Munoz, J. Alcazar,* A. de la Hoz, A. Diaz-Ortiz, S.-A. A. de Diego Green Chemistry 2012, 14, 13351341.

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  • “Orifice microreactor for the production of an organic peroxide non-reactive and reactive characterization” T. Illg,* V. Hessel, P. Löb, J. C. Schouten Green Chemistry 2012, 14, 14201433.

  • Direct oxidative amidation of aromatic aldehydes using aqueous hydrogen peroxide in continuous flow microreactor systemsX. Liu, K. F. Jensen* Green Chemistry 2012, 14, 14711474.

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  • Catalytic conversion of biomass using solvents derived from ligninP. Azadi, R. Carrasquillo-Flores, Y. J. Pagan-Torres, E. I. Gürbüz, R. Farnood, J. A. Dumesic* Green Chemistry 2012, 14, 15731576.

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  • Biodiesel process intensification: The role of the liquid–liquid interface area in the achievement of a complete conversion in few secondsE. Santacesaria,* R. Turco, M. Tortorelli, V. Russo, M. Di Serio, R. Tesser Green Processing and Synthesis 2012, 1, 181189.

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  • Continuous flow synthesis of ß-amino a,ß-unsaturated esters in aqueous mediumR. A. Joshi, R. R. Joshi, J. Tibhe, N. T. Nivangune, A. A. Kulkarni* Green Processing and Synthesis 2012, 1, 205210.

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  • Microwave-assisted continuous flow synthesis on industrial scaleR. Morschhäuser,* M. Krull, C. Kayser, C. Boberski, R. Bierbaum, P. A. Püschner, T. N. Glasnov, C. O. Kappe Green Processing and Synthesis 2012, 1, 281290.

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  • Continuous flow catalysis with a biomimetic copper(II) complex covalently immobilized on graphite feltR. Marion, G. Muthusamy, F. Geneste* Journal of Catalysis 2012, 286, 266272.

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  • Synthesis of nickel nanoparticles by hydrazine reduction: Mechanistic study and continuous flow synthesis” Ravi Eluri,* Brian Paul Journal of Nanoparticle Research 2012, 14, 800814.

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  • High-pressure catalytic chemical vapor deposition of ferromagnetic ruthenium-containing carbon nanostructuresV. O. Khavrus,* E. M. M. Ibrahim, A. Bachmatiuk, M.H. Rümmeli, A. U. B. Wolter, S. Hampel, A. Leonhardt Journal of Nanoparticle Research 2012, 14, 914924.

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  • Alumina-grafted macro-/mesoporous silica monoliths as continuous flow microreactors for the Diels–Alder reactionA. Sachse, V. Hulea, A. Finiels, B. Coq, F. Fajula, A. Galarneau* Journal of Catalysis 2012, 287, 6267.

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  • Epoxidation of olefins with a silica-supported peracid in supercritical carbon dioxide under flow conditionsR. Mello, A. Alcalde-Aragones, A. Olmos, M. E. Gonzalez-Nunez,* G. Asensio Journal of Organic Chemistry 2012, 77, 47064710.

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  • Modular microfluidic reactor and inline filtration system for the biocatalytic synthesis of chiral metabolitesB. O'Sullivan, H. Al-Bahrani, J. Lawrence, M. Campos, A. Cazares, F. Baganz, R. Wohlgemuth, H. C. Hailes, N. Szita* Journal of Molecular Catalysis B: Enzymatic 2012, 77, 18.

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  • Isothermal reactor for continuous flow microwave-assisted chemical reactionM. Matsuzawa,* S. Togashi, S. Hasebe Journal of Thermal Science and Technology 2012, 7, 5874.

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  • Controlling bubbles using bubbles—microfluidic synthesis of ultra-small gold nanocrystals with gas-evolving reducing agentsS. A. Khan,* S., Duraiswamy* Lab on a Chip 2012, 12, 18071812.

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  • Microreactor with integrated temperature control for the synthesis of CdSe nanocrystalsS. G. de Pedro, C. S. Martinez-Cisneros, M. Puyol, J. Alonso-Chamarro* Lab on a Chip 2012, 12, 19791986.

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  • Size-controlled flow synthesis of gold nanoparticles using a segmented flow microfluidic platformV. S. Cabeza, S. Kuhn, A. A. Kulkarni, K. F. Jensen* Langmuir 2012, 28, 70077013.

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  • Effect of flow dynamics on the growth kinetics of CdS thin films in chemical bath depositionM. E. Erkan, M. H.-C. Jin* Materials Chemistry and Physics 2012, 133, 779783.

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  • Ultrasound-assisted click chemistry in continuous flowN. P. Tu,* J. E. Hochlowski, S. W. Djuric Molecular Diversity 2012, 16, 5358.

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  • Highly efficient Suzuki cross-coupling reaction within an open channel plastic microreactor immobilized with palladium complexesH. Li, X. Gao, H. Ding, M. Yang, Q. Pu* Microfluidics and Nanofluidics 2012, 12, 981989.

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  • Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile saltsF. Venturoni, A. Gioiello,* R. Sardella, B. Natalini, R. Pellicciari Organic & Biomolecular Chemistry 2012, 10, 41094115.

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  • Diastereoselective 1,3-dipolar cycloaddition of pyrylium ylides with chiral enamidesK. Tchabanenko,* C. Sloan, Y.-M. Bunetel, P. Mullen Organic & Biomolecular Chemistry 2012, 10, 42154219.

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  • A continuous homologation of esters: An efficient telescoped reduction olefination sequenceD. Webb, T. F. Jamison* Organic Letters 2012, 14, 24652467.

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  • Application of microflow conditions to visible light photoredox catalysisM. Neumann, K. Zeitler* Organic Letters 2012, 14, 26582661.

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  • A flow-based synthesis of 2-aminoadamantane-2-carboxylic acidC. Battilocchio,* I. R. Baxendale, M. Biava, M. O. Kitching, S. V. Ley Organic Process Research and Development 2012, 16, 798810.

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  • Alkylation of substituted benzoic acids in a continuous flow microfluidic microreactor: Kinetics and linear free energy relationshipsA. Gholamipour-Shirazi, C. Rolando* Organic Process Research and Development 2012, 16, 811818.

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  • Managing solids in microreactors for the upstream continuous processing of fine chemicalsR. L. Hartman* Organic Process Research and Development 2012, 16, 870878.

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  • High output continuous nitrationJ. R. Gage,* X. Guo, J. Tao, C. Zheng Organic Process Research and Development 2012, 16, 930933.

  • Development of a continuous Schotten?-?Baumann route to an acyl sulfonamideT. D. White,* K. D. Berglund, J. M. Groh, M. D. Johnson, R. D. Miller, M. H. Yates Organic Process Research and Development 2012, 16, 939957.

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  • Multikilogram synthesis of 4-d-erythronolactone via batch and continuous processingL. L. Wong,* R. L. Wong, G. Loh, P. E. W. Tan, S. K. Teoh, S. M. Shaik, P. N. Sharratt, W. Chew, S. Teng Tan, D. Wang Organic Process Research and Development 2012, 16, 10031012.

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  • Scaling up biocatalysis reactions in flow reactorsG. Gasparini,* I. Archer, E. Jones, R. Ashe Organic Process Research and Development 2012, 16, 10131016.

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  • Development and scale-up of a continuous, high-pressure, asymmetric hydrogenation reaction, workup, and isolationM. D. Johnson,* S. A. May,* J. R. Calvin, J. Remacle, J. R. Stout, W. D. Diseroad, N. Zaborenko, B. D. Haeberle, W.-M. Sun, M. T. Miller, J. Brennan Organic Process Research and Development 2012, 16, 10171038.

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  • Convergent, kilogram scale synthesis of an Akt kinase inhibitorP. Grongsaard,* P. G. Bulger, D. J. Wallace, L. Tan, Q. Chen, S. J. Dolman, J. Nyrop, R. S. Hoerrner, M. Weisel, J. Arredondo, T. Itoh, C. Xie, X. Wen, D. Zhao, D. J. Muzzio, E. M. Bassan, C. S. Shultz Organic Process Research and Development 2012, 16, 10691081.

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  • Synthesis of phenylboronic acids in continuous flow by means of a multijet oscillating disc reactor system operating at cryogenic temperaturesD. Sleveland, H.-R. Bjørsvik* Organic Process Research and Development 2012, 16, 11211130.

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  • A continuous base-catalyzed methylation of phenols with dimethyl carbonate” Ulf Tilstam* Organic Process Research and Development 2012, 16, 11501153.

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  • Copper mediated controlled radical polymerization of methyl acrylate in the presence of ascorbic acid in a continuous tubular reactorN. Chan, M. F. Cunningham,* R. A. Hutchinson* Polymer Chemistry 2012, 3, 13221333.

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  • Continuous synthesis of l-malic acid using whole-cell microreactorG. Stojkovic, P. Znidarsic-Plazl* Process Biochemistry 2012, 47, 11021107.

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  • An improved microfluidics approach for monitoring real-time interaction profiles of ultrafast molecular recognitionS. Batabyal, S. Rakshit, S. Kar, S. K. Pal* Review of Scientific Instruments 2012, 83, 043113/1–6.

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  • Construction of CdSe/ZnS quantum dot microarray in a microfluidic chipH. Liu, Y. Y. Jing, X. Yu, D. W. Pang, Z. L. Zhang* Science China—Chemistry 2012, 55, 543549.

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  • Continuous-flow processing of gaseous ammonia using a Teflon AF-2400 tube-in-tube reactor: Synthesis of thioureas and in-line titrationsD. L. Browne, M. O'Brien, P. Koos, P. B. Cranwell, A. Polyzos, S. V. Ley* Synlett 2012, 14021406.

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  • Continuous flow synthesis of secondary amides by tandem azidation–amidation of anilinesC. Spiteri, J. E. Moses Synlett 2012, 15461548.

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  • Reagent-controlled stereoselective synthesis of (±)-gallo- and (±)-epigallo-catechin gallatesH. Tanaka,* A. Chino, T. Takahashi* Tetrahedron Letters 2012, 53, 24932495.

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  • “High-speed microwave assisted synthesis of SEA0400—a selective inhibitor of the Na+/Ca2+ exchanger” G. G. de la Cruz, K. Groschner, C. O. Kappe,* T. N. Glasnov* Tetrahedron Letters 2012, 53, 37313734.

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  • “Sonocatalyzed facile and mild one pot synthesis of gem-dichloroaziridine derivatives under alkaline conditions” H. Naeimi,* K. Rabiei Ultrasonics Sonochemistry 2012, 19, 130135.

  • “Flow chemistry a key enabling technology for (multistep) organic synthesis” J. Wegner, S. Ceylan, A. Kirschning* Advanced Synthesis and Catalysis 2012, 354, 1757.

  • Microfluidics: From engineering to life sciencesM. D. Leonida,* I. Kumar Current Nanoscience 2012, 8, 458473.

  • Micro reactor and flow chemistry for industrial applications in drug discovery and developmentP. T. Baraldi,* V., Hessel* Green Processing and Synthesis 2012, 1, 149167.

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  • Continuous flow synthesis. A pharma perspectiveL. Malet-Sanz,* F. Susanne Journal of Medicinal Chemistry 2012, 55, 40624098.

  • Supercritical microfluidics: Opportunities in flow-through chemistry and materials scienceS. Marre, Y. Roig, C. Aymonier* Journal of Supercritical Fluids 2012, 66, 251264.

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