View More View Less
  • 1 Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510, Japan
Restricted access

Abstract

Vinyllithiums were effectively generated by bromine–lithium exchange reaction of vinyl bromides with one eq of s-BuLi in a flow microreactor system at 0 °C or 20 °C, although two eq of t-BuLi and much lower temperatures are required for a conventional macro batch reaction. Subsequent reactions with various electrophiles in the flow microreactor system gave the corresponding vinyl compounds in good yields.

Supplementary Materials

    • Supplementary Material