Journal of Flow Chemistry
Volume/Issue:
Volume 2: Issue 3
Synthesis of Fluorinated Glycosyl Amino Acid Building Blocks for MUC1 Cancer Vaccine Candidates by Microreactor-Assisted Glycosylation
Authors:
Thomas Oberbillig Johannes Gutenberg-University Mainz, Carl-Duesbergweg 10-14, 55128, Mainz, Germany
IMM Institut fuer Mikrotechnik Mainz GmbH, Carl Zeiss Str. 18-20, 55129, Mainz, Germany

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Holger Löwe Johannes Gutenberg-University Mainz, Carl-Duesbergweg 10-14, 55128, Mainz, Germany
IMM Institut fuer Mikrotechnik Mainz GmbH, Carl Zeiss Str. 18-20, 55129, Mainz, Germany

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, and
Anja Hoffmann-Röder Johannes Gutenberg-University Mainz, Carl-Duesbergweg 10-14, 55128, Mainz, Germany
Ludwigs Maximilian-University Munich, Butenandtstr. 5-13, 81377, Munich, Germany

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Pages:
83–86
Online Publication Date:
14 Sep 2012
Publication Date:
14 Sep 2012
Article Category:
Research Article
DOI:
https://doi.org/10.1556/jfc-d-12-00011
Keywords:
fluorinated glycosyl amino acids; continuous flow; micro reactor; glycosylation
Restricted access

Abstract

MUC1-type glycopeptides have already shown their potential as possible cancer vaccine candidates. In addition, first examples of fluorinated antigen structures, especially containing the Thomsen–Friedenreich antigen, with similar antibody recognition have been reported. Using microreactor techniques for improvement of the crucial step, the complex glycosylation reactions, is an efficient way to find optimized reaction parameter as well as to circumvent well-known scale-up drawbacks. Besides, this is the first report of continuous flow glycosylations of glycosyl amino acids, in particular with fluorinated glycosyl building blocks.

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Cover Journal of Flow Chemistry
Journal of Flow Chemistry A Journal of the Flow Chemistry Society
Print ISSN:
2062-249X
Online ISSN:
2063-0212

To see the editorial board, please visit the website of Springer Nature.

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Journal of Flow Chemistry
Language English
Size A4
Year of
Foundation		 2011
Volumes
per Year		 1
Issues
per Year		 4
Founder Áramlásos Kémiai Tudományos Társaság
Founder's
Address		 H-1031 Budapest, Hungary Záhony utca 7.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 2062-249X (Print)
ISSN 2063-0212 (Online)

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