Authors:
René Becker FutureChemistry Holding B.V., Toernooiveld 100, 6525, EC Nijmegen, The Netherlands

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Sebastiaan (Bas) A.M.W. van den Broek FutureChemistry Holding B.V., Toernooiveld 100, 6525, EC Nijmegen, The Netherlands

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Pieter J. Nieuwland FutureChemistry Holding B.V., Toernooiveld 100, 6525, EC Nijmegen, The Netherlands

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Kaspar Koch FutureChemistry Holding B.V., Toernooiveld 100, 6525, EC Nijmegen, The Netherlands

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Floris P.J.T. Rutjes Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525, AJ Nijmegen, The Netherlands

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Abstract

To expand the knowledge base for fundamental organic reactions in continuous flow, the α-bromination of acetophenone was successfully transformed from a known batch procedure to a continuous flow process in 99 % yield through D-optimal optimisation and subsequent scale-up of the validated optimum. Using a preparative scale system, a space–time yield of 0.26 kg/m3/s (comparable literature batch reaction 0.24 kg/m3/s) was achieved under conditions suitable for laboratory and small-scale industrial application where high yield or purity is required, e.g., when expensive substrates are used.

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Journal of Flow Chemistry
Language English
Size A4
Year of
Foundation
2011
Volumes
per Year
1
Issues
per Year
4
Founder Áramlásos Kémiai Tudományos Társaság
Founder's
Address
H-1031 Budapest, Hungary Záhony utca 7.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2062-249X (Print)
ISSN 2063-0212 (Online)