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  • 1 Institute of Chemistry, Karl-Franzens-University Graz, A-8010, Heinrichstrasse 28, Graz, Austria
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Abstract

In this section of the journal, the continuous flow chemistry literature of the preceding months is presented. Included are articles published in the period July–September 2012. Some key examples are highlighted in the form of graphical abstracts. The remaining publications in the field are then listed ordered by journal name, with review articles grouped at the end.

  • Metal-free oxidative fluorination of phenols with [18 F]fluorideZ. Gao, Y. H. Lim, M. Tredwell, L. Li, S. Verhoog, M. Hopkinson, W. Kaluza, T. L. Collier, J. Passchier, M. Huiban, V. Gouverneur Angewandte Chemie International Edition 2012, 51, 67336737.

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  • Microfluidic control of the internal morphology in nanofiber-based macroscopic cablesD. Kiriya, R. Kawano, H. Onoe, S. Takeuchi Angewandte Chemie International Edition 2012, 51, 79427947.

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  • “Stereoselective chemoenzymatic synthesis of enantiopure 2-(1 H–imidazol-yl)cycloalkanols under continuous flow conditions” R. Porcar, V. Sans, N. Ríos-Lombardía, V. Gotor-Fernández, V. Gotor, M. I. Burguete, E. García-Verdugo, S. V. Luis ACS Catalysis 2012, 2, 19761983.

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  • A new flow methodology for the expedient synthesis of drug-like 3-aminoindolizinesP. P. Lange, A. R. Bogdan, K. Jamesa Advanced Synthesis and Catalysis 2012, 354, 23732379.

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  • [18 F]FE@SNAP—a new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): Microfluidic and vessel-based approachesC. Philippe, J. Ungersboeck, E. Schirmer, M. Zdravkovic, L. Nics, M. Zeilinger, K. Shanab, R. Lanzenberger, G. Karanikas, H. Spreitzer, H. Viernstein, M. Mitterhauser, W. Wadsak Bioorganic & Medicinal Chemistry 2012, 20, 59365940.

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  • Heterogeneous enantioselective hydrogenation in a continuous flow fixed-bed reactor system: Hydrogenation of activated ketones and their binary mixtures on Pt–alumina–cinchona alkaloid catalystsG. Szöllösi, Z. Makra, M. Fekete, F. Fülöp, M. Bartok Catalysis Letters 2012, 142, 889894.

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  • Zeolite capillary microreactor by flow synthesis methodG. Zhang, X. Zhang, J. Lv, H. Liu, J. Qiu, K. L. Yeung Catalysis Today 2012, 193, 221225.

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  • Continuous flow photocatalysis enhanced using an aluminum mirror: Rapid and selective synthesis of 20-deoxy and 20,30-dideoxynucleosidesB. Shen, M. W. Bedore, A. Sniady, T. F. Jamison Chemical Communications 2012, 48, 74447446.

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  • Segmented flow synthesis of Ag nanoparticles in spiral microreactor: Role of continuous and dispersed phaseD. V. R. Kumar, B. L. V. Prasad, A. A. Kulkarni Chemical Engineering Journal 2012, 192, 357368.

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  • Microflow synthesis of saccharide nucleoside diphosphate with cross-coupling reactions of monophosphate componentsK.-H. Chen, W.-F. Fang, Y.-T. Chen, J.-M. Fang, J.-T. Yang Chemical Engineering Journal 2012, 198–199, 3337.

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  • Synthesis of water-borne polymer nanoparticles in a continuous microreactorA. K. Yadav, M. J. Barandiaran, J. C. de la Cal Chemical Engineering Journal 2012, 198–199, 191200.

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  • A novel vapor–liquid segmented flow based on solvent partial vaporization in microstructured reactor for continuous synthesis of nickel nanoparticlesC. Zeng, C. Wang, F. Wang, Y. Zhang, L. Zhang Chemical Engineering Journal 2012, 204–206, 4853.

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  • Microfluidic biosynthesis of silver nanoparticles: Effect of process parameters on size distributionH. Liu, J. Huang, D. Sun, L. Lin, W. Lin, J. Li, X. Jiang, W. Wu, Q. Li Chemical Engineering Journal 2012, 209, 568576.

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  • Establishing a flow process to coumarin-8-carbaldehydes as important synthetic scaffoldsJ. Zak, D. Ron, E. Riva, H. P. Harding, B. C. S. Cross, I. R. Baxendale Chemistry—A European Journal 2012, 18, 99019910.

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  • Microreactor combinatorial system for nanoparticle synthesis with multiple parametersK. Watanabe, Y. Orimoto, K. Nagano, K. Yamashita, M. Uehara, H. Nakamura, T. Furuya, H. Maeda Chemical Engineering Science 2012, 75, 292297.

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  • Oxidations with bonded salen-catalysts in microcapillariesS. Sandel, S. K. Weber, O. Trapp Chemical Engineering Science 2012, 83, 171179.

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  • Production of hyaluronic acid (HA) nanoparticles by a continuous process inside microchannels: Effects of non-solvents, organic phase flow rate, and HA concentrationR. C. S. Bicudo, M. H. A. Santana Chemical Engineering Science 2012, 84, 134141.

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  • Simulation of a compact multichannel membrane reactor for the production of pure hydrogen via steam methane reformingA. Vigneault, S. S. E. H. Elnashaie, J. R. Grace Chemical Engineering & Technology 2012, 35, 15201533.

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  • Direct fluorination of 1,3-dicarbonyl compound in a continuous flow reactor at industrial scaleS. Elgue, A. Conte, C. Gourdon, Y. Bastard Chemistry Today 2012, 30, 1821.

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  • Continuous synthesis of peralkylated imidazoles and their transformation into ionic liquids with improved (electro) chemical stabilitiesC. Maton, N. De Vos, B. I. Roman, E. Vanecht, N. R. Brooks, K. Binnemans, S. Schaltin, J. Fransaer, C. V. Stevens ChemPhysChem 2012, 13, 31463157.

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  • “Synthesis of Cu2ZnSnS4 micro- and nanoparticles via a continuous-flow supercritical carbon dioxide process” M. J. Casciato, G. Levitin, D. W. Hess, M. A. Grover ChemSusChem 2012, 5, 11861189.

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  • Copper(I)-catalyzed azide–alkyne cycloadditions in microflow: Catalyst activity, high-t operation, and an integrated continuous copper scavenging unitA. C. Varas, T. Noël, Q. Wang, V. Hessel ChemSusChem 2012, 5, 17031707.

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  • Metal-free aerobic alcohol oxidation: Intensification under three-phase flow conditionsC. Aellig, D. Scholz, I. Hermans ChemSusChem 2012, 5, 17321736.

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  • Continuous d-fructose dehydration to 5-hydroxymethylfurfural under mild conditionsC. Aellig, I. Hermans ChemSusChem 2012, 5, 17371742.

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  • Single-step radiosynthesis of “18 F-labeled click synthons” from azide-functionalized diaryliodonium salts” J.-H. Chun, V. W. Pike European Journal of Organic Chemistry 2012, 45414547.

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  • Window of opportunity—potential of increase in profitability using modular compact plants and micro-reactor based flow processingI. V. Gürsel, V. Hessel, Q. Wang, T. Noël, J. Lang Green Processing and Synthesis 2012, 1, 315336.

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  • Impact of the design and the materials of rectangular microchannel reactors on the photocatalytic decomposition of organic pollutantG. Charles, T. Roques-Carmes, N. Becheikh, L. Falk, S. Corbel Green Processing and Synthesis 2012, 1, 363374.

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  • A pH-sensitive laser-induced fluorescence technique to monitor mass transfer in multiphase flows in microfluidic devicesS. Kuhn, K. F. Jensen Industrial & Engineering Chemistry Research 2012, 51, 89999006.

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  • Controllable preparation of polyacrylamide hydrogel microspheres in a coaxial microfluidic deviceB. Yang, Y. Lu, G. Luo Industrial & Engineering Chemistry Research 2012, 51, 90169022.

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  • Continuous synthesis and in situ monitoring of biodiesel production in different microfluidic devicesE. L. M. Arias, P. F. Martins, A. L. J. Munhoz, L. Gutierrez-Rivera, R. M. Filho Industrial & Engineering Chemistry Research 2012, 51, 1075510767.

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  • Micromixing efficiency of a spinning disk reactorN. C. Jacobsen, O. Hinrichsen Industrial & Engineering Chemistry Research 2012, 51, 1164311652.

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  • Continuous-flow synthesis of monoarylated acetaldehydes using aryldiazonium saltsN. Chernyak, S. L. Buchwald Journal of the American Chemical Society 2012, 134, 1246612469.

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  • Multiphase flow systems for selective aerobic oxidation of alcohols catalyzed by bimetallic nanoclustersK. Kaizuka, K.-Y. Lee, H. Miyamura, S. Kobayashi Journal of Flow Chemistry 2012, 2, 14.

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  • Phase-transfer catalysis under continuous flow conditions: An alternative approach to the biphasic liquid/liquid O-alkylation of phenolsD. De Zani, M. Colombo Journal of Flow Chemistry 2012, 2, 57.

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  • Safe generation and synthetic utilization of hydrazoic acid in a continuous flow reactorB. Gutmann, D. Obermayer, J.-P. Roduit, D. M. Roberge, C. O. Kappe Journal of Flow Chemistry 2012, 2, 819.

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  • Acyl azide synthesis and curtius rearrangements in microstructured flow chemistry systemsH. Sprecher, M. N. P. Payán, M. Weber, G. Yilmaz, G. Wille Journal of Flow Chemistry 2012, 2, 2023.

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  • “The effect of self-optimisation targets on the methylation of alcohols using dimethyl carbonate in supercritical CO2D. N. Jumbam, R. A. Skilton, A. J. Parrott, R. A. Bourne, M. Poliakoff Journal of Flow Chemistry 2012, 2, 2427.

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  • Positron emission tomography radiosynthesis in microreactorsP. Watts, G. Pascali, P. A. Salvadori Journal of Flow Chemistry 2012, 2, 3742.

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  • User friendly and flexible Kiliani reaction on ketoses using microreaction technologyA. Cukalovic, J.-C. M. Monbaliu, G. J. Heynderickx, C. V. Stevens Journal of Flow Chemistry 2012, 2, 4346.

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  • Acetylation of alcohols and phenols using continuous-flow, tungstosilicic acid-supported, monolith microreactors with scale-up capabilityP. He, S. J. Haswell, P. D. I. Fletcher, S. M. Kelly, A. Mansfield Journal of Flow Chemistry 2012, 2, 4651.

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  • Synthesis of juglone (5-hydroxy-1,4-naphthoquinone) in a falling film microreactorO. Shvydkiv, C. Limburg, K. Nolan, M. Oelgemöller Journal of Flow Chemistry 2012, 2, 5255.

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  • Simplified mesofluidic systems for the formation of micron to millimeter droplets and the synthesis of materialsJ. L. Steinbacher, Y. Lui, B. P. Mason, W. L. Olbricht, D. T. McQuade Journal of Flow Chemistry 2012, 2, 5662.

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  • Generation and reactions of vinyllithiums using flow microreactor systemsA. Nagaki, Y. Takahashi, S. Yamada, C. Matsuo, S. Haraki, Y. Moriwaki, S. Kim, J.-I. Yoshida Journal of Flow Chemistry 2012, 2, 7072.

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  • Diastereoselective [2+2] photocycloaddition of a chiral cyclohexenone with ethylene in a continuous flow microcapillary reactorK. Terao, Y. Nishiyama, H. Tanimoto, T. Morimoto, M. Oelgemöller, K. Kakiuchi Journal of Flow Chemistry 2012, 2, 7376.

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  • A method to identify best available technologies (BAT) for hydrogenation reactors in the pharmaceutical industryT. Van Le Doan, P. Stavárek, C. de Bellefon Journal of Flow Chemistry 2012, 2, 7782.

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  • Synthesis of fluorinated glycosyl amino acid building blocks for MUC1 cancer vaccine candidates by microreactor-assisted glycosylationT. Oberbillig, H. Löwe, A. Hoffmann-Röder Journal of Flow Chemistry 2012, 2, 8386.

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  • Optimisation and scale-up of α-bromination of acetophenone in a continuous flow microreactorR. Becker, S. A. M. W. van den Broek, P. J. Nieuwland, K. Koch, F. P. J. T. Rutjes Journal of Flow Chemistry 2012, 2, 8791.

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  • Controlled synthesis of silica capsules: Taming the reactivity of sicl4 using flow and chemistryL. Z. Miller, J. L. Steinbacher, T. I. Houjeiry, A. R. Longstreet, K. L. Woodberry, B. F. Gupton, B. Chen, R. Clark, D. T. McQuade Journal of Flow Chemistry 2012, 2, 92102.

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  • Combinatorial synthesis of peptidomimetics using digital microfluidicsM. J. Jebrail, N. Assem, J. M. Mudrik, M. D. M. Dryden, K. Lin, A. K. Yudin, A. R. Wheeler Journal of Flow Chemistry 2012, 2, 103107.

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  • Direct fluorination of carbon monoxide in microreactorsW. Navarrini, F. Venturini, V. Tortelli, S. Basak, K. P. Pimparkar, A. Adamo, K. F. Jensen Journal of Fluorine Chemistry 2012, 142, 1923.

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  • Investigation of the mechanism of ozonolysis of (Z)-3-methyl-2-pentene using matrix isolation infrared spectroscopyB. E. Coleman, B. Ault Journal of Molecular Structure 2012, 1031, 138143.

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  • A remote photochemical reaction for surface modification of polymeric substrateC. Zhao, Z. Zhang, W. Yang Journal of Polymer Science Part A: Polymer Chemistry 2012, 50, 36983702.

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  • Enzyme-catalyzed polymerization of end-functionalized polymers in a microreactorA. S. Bhangale, K. L. Beers, R. A. Gross Macromolecules 2012, 45, 70007008.

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  • Engaging unactivated alkyl, alkenyl and aryl iodides in visible-light-mediated free radical reactionsJ. D. Nguyen, E. M. D'Amato, J. M. R. Narayanam, C. R. J. Stephenson Nature Chemistry 2012, 4, 854859.

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  • A prototype continuous-flow liquid–liquid extraction system using open-source technologyM. O'Brien, P. Koos, D. L. Browne, S. V. Ley Organic & Biomolecular Chemistry 2012, 10, 70317036.

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  • Rapid continuous synthesis of 50-deoxyribonucleosides in flow via Brønsted acid catalyzed glycosylationB. Shen, T. F. Jamison Organic Letters 2012, 14, 33483351.

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  • A “CatchReactRelease” method for the flow synthesis of 2-aminopyrimidines and preparation of the imatinib baseR. J. Ingham, E. Riva, N. Nikbin, I. R. Baxendale, S. V. Ley Organic Letters 2012, 14, 39203923.

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  • Parallel microflow photochemistry: Process optimization, scale-up, and library synthesisA. Yavorskyy, O. Shvydkiv, N. Hoffmann, K. Nolan, M. Oelgemöller Organic Letters 2012, 14, 43424345.

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  • Automated multitrajectory method for reaction optimization in a microfluidic system using online IR analysisJ. S. Moore, K. F. Jensen Organic Process Research and Development 2012, 16, 14091415.

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  • Nitration under continuous flow conditions: Convenient synthesis of 2-isopropoxy-5-nitrobenzaldehyde, an important building block in the preparation of nitro-substituted Hoveyda-Grubbs metathesis catalystP. Knapkiewicz, K. Skowerski, D. E. Jasko´lska, M. Barbasiewicz, T. K. Olszewski Organic Process Research and Development 2012, 16, 14301435.

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  • Continuous-flow preparation and use of ß-chloro enals using the Vilsmeier reagentL. Pellegatti, S. L. Buchwald Organic Process Research and Development 2012, 16, 14421448.

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  • Isoamyl acetate synthesis in imidazolium-based ionic liquids using packed bed enzyme microreactorM. Cvjetko, J. Vorkapic-Furac, P. Znidarsic-Plazl Process Biochemistry 2012, 47, 13441350.

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  • “An efficient synthesis of 2-(trifluoromethyl)-2 H-[1,3]oxazino[2,3- a]isoquinolines via a three-component cascade approach using a continuous-flow microreactor” M. Lei, W. Tian, R. Hu, H. Zhang Synthesis 2012, 44, 25192526.

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  • Synthesis of an isoindoline-annulated, tricyclic sultam library via microwave-assisted, continuous-flow organic synthesis (MACOS)F. Ullah, Q. Zang, S. Javed, P. Porubsky, B. Neuenswander, G. H. Lushington, P. R. Hanson, M. G. Organ Synthesis 2012, 44, 25472554.

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  • 100 Gram scale synthesis of a key intermediate of matrix metalloproteinase inhibitor in a continuous-flow system based on a copper-free Sonogashira reaction using an ionic liquid as a catalyst supportT. Fukuyama, M. T. Rahman, Y. Sumino, I. Ryu Synlett 2012, 23, 22792283.

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  • 4'-Methylbiphenyl-2-carbonitrile synthesis by continuous flow Suzuki–Miyaura reactionG. O. D. Estrada, M. C. Flores, J. F. M. da Silva, R. O. M. A. de Souza, L. S. M. Miranda Tetrahedron Letters 2012, 53, 41664168.

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  • Synthesis of thiol-capped gold nanoparticle with a flow system using organosilane as a reducing agentA. Sugie, H. Song, T. Horie, N. Ohmura, K. Kanie, A. Muramatsu, A. Mori Tetrahedron Letters 2012, 53, 44574459.

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  • A scalable approach to diaminopyrazoles using flow chemistryN. S. Wilson, A. T. Osuma, J. A. Van Camp, X. Xu Tetrahedron Letters 2012, 53, 44984501.

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  • Photodecarboxylative addition of carboxylates to phthalimides: A concise access to biologically active 3-(alkyl and aryl)methylene- H-isoindolin-1-onesF. Hatoum, J. Engler, C. Zelmer, J. Wißen, C. A. Motti, J. Lex, M. Oelgemöller Tetrahedron Letters 2012, 53, 55735577.

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  • Microflow photochemistry—a reactor comparison study using the photochemical synthesis of terebic acid as a model reactionS. Aida, K. Terao, Y. Nishiyama, K. Kakiuchi, M. Oelgemöller Tetrahedron Letters 2012, 53, 55785581.

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  • “Hydrodechlorination reactions of CCl4 over HZSM-5- and HY-supported Pt and Pd catalysts” A. Fasi, I. Hannus, J. Halasz, I. Palinko Topics in Catalysis 2012, 55, 853857.

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  • Overcoming the limitations of lithiation chemistry for organoboron compounds with continuous processingAngewandte Chemie International Edition 2012, 51, 92239225.

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  • Monitoring and control of microbioreactors: An expert opinion on development needsK. V. Gernaey, F. Baganz, E. Franco-Lara, F. Kensy, U. Krühne, M. Luebberstedt, U. Marx, E. Palmqvist, A. Schmid, F. Schubert, C.-F. Mandenius Biotechnology Journal 2012, 7, 17.

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  • Sustainable, efficient and safe processes through the use of flow and catalytic reactionsD. Ager, P. Poechlauer Chemistry Today 2012, 30, 4244.

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  • On-site-on demand production of hazardous chemicals by continuous flow processesP. Poechlauer, S. Braune, B. Dielemans, B. Kaptein, R. Obermüller, M. Thathagar Chemistry Today 2012, 30, 5154.

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  • Biofilms as living catalysts in continuous chemical synthesesB. Halan, K. Buehler, A. Schmid Trends in Biotechnology 2012, 30, 453465.

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