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  • 1 Institute of Chemistry, Karl-Franzens University Graz, Heinrichstrasse 28, A-8010, Graz, Austria
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Abstract

In this section of the journal, the continuous-flow chemistry literature of the preceding months is presented. Included are articles published in the period January–March 2013. Some key examples are highlighted in the form of graphical abstracts. The remaining publications in the field are then listed ordered by journal name, with review articles grouped at the end.

  • Continuous Multistep Microfluidic Assisted Assembly of Fluorescent, Plasmonic, and Magnetic NanostructuresN. Hassan, V. Cabuil, A. Abou-Hassan* Angewandte Chemie International Edition 2013, 52, 19941997.

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  • Mild and Rapid Pd-Catalyzed Cross-Coupling with Hydrazine in Continuous Flow: Application to the Synthesis of Functionalized HeterocyclesA. DeAngelis, D.-H. Wang, S. L. Buchwald* Angewandte Chemie International Edition 2013, 52, 34343437.

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  • Effect of Reaction Conditions on the Direct Synthesis of Hydrogen Peroxide with a AuPd/TiO2 Catalyst in a Flow ReactorS. J. Freakley, M. Piccinini, J. K. Edwards, E. N. Ntainjua, J. A. Moulijn, G. J. Hutchings* ACS Catalysis 2013, 3, 487501.

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  • Fabrication and Characterization of Stable Hydrophilic Microfluidic Devices Prepared via the in Situ Tertiary-Amine Catalyzed Michael Addition of Multifunctional Thiols to Multifunctional AcrylatesC. O. Bounds, J. Upadhyay, N. Totaro, S. Thakuri, L. Garber, M. Vincent, Z. Huang, M. Hupert, J. A. Pojman* ACS Applied Materials & Interfaces 2013, 5, 16431655.

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  • Continuous-Flow Asymmetric Hydrogenation of the β-Keto Ester Methyl Propionylacetate in Ionic Liquid–Supercritical Carbon Dioxide Biphasic SystemsJ. Theuerkauf, G. Franci,* W. Leitner* Advanced Synthesis and Catalysis 2013, 355, 209219.

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  • Synthesis of Functionalized Aryl Fluorides Using Organolithium Reagents in Flow MicroreactorsA. Nagaki, Y. Uesugi, H. Kim, J.-i. Yoshida* Chemistry — An Asian Journal 2013, 8, 705708.

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  • Alkyne–Azide Cycloadditions with Copper Powder in a High-Pressure Continuous-Flow Reactor: High-Temperature Conditions versus the Role of Additives” S. B. Ötvös, I. M. Mandity, L. Kiss, Ferenc Fülöp* Chemistry — An Asian Journal 2013, 8, 800808.

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  • Shape-Selective Growth of Silver Nanoparticles under Continuous Flow Photochemical ConditionsS. Silvestrini, T. Carofiglio,* M., Maggini* Chemical Communications 2013, 49, 8486.

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  • Reactions of Organolithiums with Dialkyl Oxalates. A Flow Microreactor Approach to Synthesis of Functionalized A-Keto EstersA. Nagaki, D. Ichinari, J.-i. Yoshida* Chemical Communications 2013, 49, 32423244.

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  • Flow Chemistry Syntheses of Styrenes, Unsymmetrical Stilbenes and Branched AldehydesS. L. Bourne, M. O'Brien, S. Kasinathan, P. Koos, P. Tolstoy, D. X. Hu, R. W. Bates, B. Martin, B. Schenkel, S. V. Ley* ChemCatChem 2013, 5, 159172.

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  • Selective Hydroalkoxylation of 1-Hexene with 1-Propanol and 1-Butanol over Zeolite Beta CatalystS. Radhakrishnan, G. Thoelen, J. Franken, J. Degreve, C. E. A. Kirschhock, J. A. Martens* ChemCatChem 2013, 5, 576581.

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  • Chemical and (Photo)-Catalytical Transformations in Photonic Crystal FibersM. Schmidt, A. M. Cubillas, N. Taccardi, T. G. Euser, T. Cremer, F. Maier, H.-P. Steinrück, P. St. J. Russell, P. Wasserscheid, Bastian. J. M. Etzold* ChemCatChem 2013, 5, 641650.

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  • Single Operation Stereoselective Synthesis of Aerangis Lactones: Combining Continuous Flow Hydrogenation and Biocatalysts in a Chemoenzymatic SequenceM. J. Fink, M. Schön, F. Rudroff, M. Schnürch, M. D. Mihovilovic* ChemCatChem 2013, 5, 724727.

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  • Synthesis of 1,2,3,4-Tetrahydroisoquinolines by Microreactor-Mediated Thermal Isomerization of Laterally Lithiated ArylaziridinesA. Giovine, B. Musio, L. Degennaro, A. Falcicchio, A. Nagaki, J.-i. Yoshida,* R., Luisi* Chemistry — A European Journal 2013, 19, 18721876.

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  • Synthesis of Carbohydrate-Functionalised Sequence-Defined Oligo(amidoamine)s by Photochemical Thiol–Ene Coupling in a Continuous Flow ReactorF. Wojcik, A. G. O'Brien, S. Götze, P. H. Seeberger,* L., Hartmann* Chemistry — A European Journal 2013, 19, 30903098.

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  • Modeling, Simulation and Optimized Design of a Microreactor for a Two-Step ReactionX. Chen,* H. Zeng, H. Wang, D. Zhang Chemical Engineering & Technology 2013, 36, 591595.

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  • Screening of Multiparameter Spaces for Silver Nanoprism Synthesis by Microsegmented Flow TechniqueA. Knauer,* J. M. Köhler Chemie Ingenieur Technik 2013, 85, 110.

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  • Enamine Catalysis in Flow with an Immobilized Peptidic CatalystY. Arakawa, H. Wennemers* ChemSusChem 2013, 6, 242245.

  • Micro/Milliflow Processing with Selective Catalyst Microwave Heating in the Cu-Catalyzed Ullmann Etherification Reaction: A μ2-ProcessF. Benaskar, N. G. Patil, E. V. Rebrov, A. Ben-Abdelmoumen, J. Meuldijk, L. A. Hulshof, V. Hessel,* J. C. Schouten ChemSusChem 2013, 6, 353366.

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  • Straightforward Microwave-Assisted Synthesis of 5,8-Disubstituted 5,6,8,9-Tetrahydro-4 H,7 H-2,5,6a,8,9a-pentaazaphenalene-1,3-dionesD. Garcia, M. Jatczak, K. Muylaert, L. M. De Coen, C. V. Stevens* European Journal of Organic Chemistry 2013, 17321739.

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  • Enantioselective Reduction of 3-Aryl-2-oxo-propanoic Acids: A Comparison of Enzymatic and Transition-Metal-Catalyzed MethodsS. Lüttenberg, T. Dat Ta, J. von der Heyden, J. Scherkenbeck * European Journal of Organic Chemistry 2013, 18241830.

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  • Safe, Efficient and Selective Synthesis of Dinitroherbicides via a Multifunctional Continuous-Flow Microreactor: One-Step Dinitration with Nitric Acid as AgentY. Chen, Y. Zhao, M. Han, C. Ye, M. Dang, G. Chen* Green Chemistry 2013, 14, 9194.

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  • Efficient Synthesis of Cyanohydrin Trimethylsilyl Ethers via 1,2-Chemoselective Cyanosilylation of CarbonylsG. Strappaveccia, D. Lanari,* D. Gelman, F. Pizzo, O. Rosati, M. Curini, L. Vaccaro* Green Chemistry 2013, 14, 199204.

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  • Highly Efficient Synthesis of Cyclic Carbonate with CO2 Catalyzed by Ionic Liquid in a MicroreactorY. Zhao, C. Yao, G. Chen,* Q. Yuan Green Chemistry 2013, 14, 446452.

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  • Continuous Flow Valorization of Fatty Acid Waste Using Silica-Immobilized LipasesI. Itabaiana Jr., F. K. Sutili, S. G. F. Leite, K. M. Gon çalves, Y. Cordeiro, I. C. R. Leal, L. S. M. Miranda, M. Ojeda, R. Luque, R. O. M. A. de Souza* Green Chemistry 2013, 14, 518524.

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  • Production of Silver Nanoparticles in a Continuous Stirred Tank Reactor Based on Plant-Mediated Biosynthesis: Flow Behaviors and Residence Time Distribution Prediction by Computational Fluid Dynamics SimulationH. Liu, J. Huang, Y. Gao, D. Sun, J. Li, X. Li, Z. Zhang, Q. Li* Industrial & Engineering Chemistry Research 2013, 52, 22802289.

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  • Hydrodeoxygenation of 4-Propylguaiacol (2-Methoxy-4-propylphenol) in a Microreactor: Performance and Kinetic StudiesN. Joshi,* A. Lawal Industrial & Engineering Chemistry Research 2013, 52, 40494058.

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  • Continuous Precipitation of Ceria Nanoparticles from a Continuous Flow MicromixerC. H. T. Tseng, B. K. Paul,* C.-H. Chang, M. H. Engelhard International Journal of Advanced Manufacturing Technology 2013, 64, 579586.

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  • Free Radical Polymerization of Butyl Acrylate in Monodispersed Droplets: Comparison Between Two Heating StrategiesL. Zhendong, L. Yangcheng, Y. Bodong, L. Guangsheng Journal of Applied Polymer Science 2013, 127, 628635.

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  • Large-Scale Synthesis of Nanocrystals in a Multichannel Droplet ReactorA. M. Nightingale, J. H. Bannock, S. H. Krishnadasan, F. T. F. O'Mahony, S. A. Haque, J. Sloan, C. Drury, R. McIntyre, J. C. deMello* Journal of Materials Chemistry A 2013, 1, 40674076.

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  • Continuous-Flow Preparation of Nanoporous Metal/Polymer Composite Particles by in situ Synthesis of Silver Nanoparticles in Photopolymerized Acrylate/Diethylene Glycol DropletsJ. M. Köhler,* I. Kraus, J. Faerber, C. Serra Journal of Materials Science 2013, 48, 21582166.

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  • Design and Synthesis of Diazatricyclodecane Agonists of the G-Protein-Coupled Receptor 119E. Darout, R. P. Robinson, K. F. McClure,* M. Corbett, B. Li, A. Shavnya, M. P. Andrews, C. S. Jones, Q. Li, M. L. Minich, V. Mascitti, C. R. W. Guimara, M. J. Munchhof, K. B. Bahnck, C. Cai, D. A. Price, S. Liras, P. D. Bonin, P. Cornelius, R. Wang, V. Bagdasarian, C. P. Sobota, S. Hornby, V. M. Masterson, R. M. Joseph, A. S. Kalgutkar, Y. Chen Journal of Medicinal Chemistry 2013, 56, 301319.

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  • Ultrafast and Continuous Synthesis of Crystalline Ferrite Nanoparticles in Supercritical EthanolO. Pascu, S. Marre, C. Aymonier,* A., Roig* Nanoscale 2013, 5, 21262132.

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  • Pulsed Supercritical Synthesis of Anatase TiO2 Nanoparticles in a Water–Isopropanol Mixture Studied by in situ Powder X-Ray DiffractionJ. R. Eltzholtz, C. Tyrsted, K. M. Ø. Jensen, M. Bremholm, M. Christensen, J. Becker-Christensen, B. B. Iversen* Nanoscale 2013, 5, 23722378.

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  • An Expeditious Synthesis of Imatinib and Analogues Utilizing Flow Chemistry MethodsM. D. Hopkin, I. R. Baxendale, S. V. Ley* Organic & Biomolecular Chemistry 2013, 11, 18221839.

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  • Hydrogen-Free Alkene Reduction in Continuous FlowA. S. Kleinke, T. F. Jamison* Organic Letters 2013, 15, 710713.

  • Green Diacetoxylation of Alkenes in a Microchemical SystemJ. H. Park, C. Y. Park, H. S. Song, Y. S. Huh, G. H. Kim, C. P. Park* Organic Letters 2013, 15, 752755.

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  • Scaffold Hopping via a Transannular Rearrangement-Encompassing CascadeJ. L. Vrijdag, A. M. Van den Bogaert, W. M. De Borggraeve* Organic Letters 2013, 15, 10521055.

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  • Generation and Reactions of Heteroaromatic Lithium Compounds by Using In-Line Mixer in a Continuous Flow Microreactor System at “ConditionsB. Liu, Y. Fan, X. Lv, X. Liu, Y. Yang, Y. Jia* Organic Process Research and Development 2013, 17, 133137.

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  • Continuous Flow Synthesis of n-Alkyl Chlorides in a High-Temperature Microreactor EnvironmentB. Reichart, G. Tekautz, C. O. Kappe* Organic Process Research and Development 2013, 17, 152157.

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  • On the Fischer Indole Synthesis of 7-Ethyltryptophol — Mechanistic and Process Intensification Studies under Continuous Flow ConditionsB. Gutmann, M. Gottsponer, P. Elsner, D. Cantillo, D. M. Roberge,* C. O. Kappe* Organic Process Research and Development 2013, 17, 294302.

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  • A High-Output, Continuous Selective and Heterogeneous Nitration of p-DifluorobenzeneZ. Yu, Y. Lv, C. Yu,* W. Su Organic Process Research and Development 2013, 17, 438442.

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  • Thinking Continuously: A Microreactor for the Production and Scale-Up of Biodegradable, Self-Assembled NanoparticlesC. Petschacher, A. Eitzlmayr, M. Besenhard, J. Wagner, J. Barthelmes, A. Bernkop-Schnürch, J. G. Khinast, A. Zimmer* Polymer Chemistry 2013, 4, 23422352.

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  • Expedient Method for Samarium(II) Iodide Preparation Utilizing a Flow ApproachS. Voltrova, J. Srogl* Synlett 2013, 24, 394396.

  • Functionalized Magnetizable Particles for Downstream Processing in Single-Use Systems” N. Tippkötter, H. Al-Kaidy, S. Wollny, R. Ulber* Chemie Ingenieur Technik 2013, 85, 7686.

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  • Microfluidic Device: A Miniaturized Platform for Chemical ReactionsQ. Tu, L. Pang, Y. Zhang, M. Yuan, J. Wang, D. Wang, W. Liu, J. Wang* Chinese Journal of Chemistry 2013, 31, 304316.

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  • Flow Photochemistry: Old Light through New WindowsJ. P. Knowles, L. D. Elliott, K. I. Booker-Milburn* Beilstein Journal of Organic Chemistry 2012, 8, 20252052.

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  • Highlights of Photochemical Reactions in Microflow ReactorsM. Oelgemöller* Chemical Engineering & Technology 2012, 35, 11441152.

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  • Membrane Microreactors: Gas–Liquid Reactions Made EasyT. Nöel,* V. Hessel ChemSusChem 2013, 6, 405407.

  • The Integration of Flow Reactors into Synthetic Organic ChemistryIan R. Baxendale* Journal of Chemical Technology and Biotechnology 2013, 88, 519552.

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