In this section of the journal, the continuous-flow chemistry literature of the preceding months is presented. Included are articles published in the period April-June 2013. Some key examples are highlighted in the form of graphical abstracts. The remaining publications in the field are then listed, ordered by journal name, with review articles grouped at the end.
“Peptide fragment coupling using a continuous-flow photochemical rearrangement of nitrones” Y. Zhang, M. L. Blackman, A. B. Leduc, T. F. Jamison* Angewandte Chemie International Edition 2013, 52, 4251–4255.
“Chemotactic behavior of catalytic motors in microfluidic channels” L. Baraban, S. M. Harazim, S. Sanchez,* O. G. Schmidt Angewandte Chemie International Edition 2013, 52, 5552–5556.
“Building a sulfonamide library by eco-friendly flow synthesis” A. Gioiello,* E. Rosatelli, M. Teofrasti, P. Filipponi, R. Pellicciari ACS Combinatorial Science 2013, 15, 235–239.
“A simple millifluidic benchtop reactor system for the high-throughput synthesis and functionalization of gold nanoparticles with different sizes and shapes” S. E. Lohse, J. R. Eller, S. T. Sivapalan, M. R. Plews, C. J. Murphy* ACS Nano 2013, 7, 4135–4150.
“Continuous synthesis of device-grade semiconducting polymers in droplet-based microreactors” J. H. Bannock, S. H. Krishnadasan, A. M. Nightingale, C. Pang Yau, K. Khaw, D. Burkitt, J. J. M. Halls, M. Heeney,* J. C. de Mello* Advanced Functional Materials 2013, 23, 2123–2129.
“Segmented flow reactors for nanocrystal synthesis” A. M. Nightingale, J. C. deMello* Advanced Materials 2013, 25, 1813–1821.
“Flock-based microfluidics” M. Hitzbleck, R. D. Lovchik, E. Delamarche* Advanced Materials 2013, 25, 2672–2676.
“Iron-catalysed borylation of arenediazonium salts to give access to arylboron derivatives via aryl(amino)boranes at room temperature” L. D. Marciasini, N. Richy, M. Vaultier, M. Pucheaulta* Advanced Synthesis and Catalysis 2013, 355, 1083–1088.
“3D-printed devices for continuous-flow organic chemistry” V. Dragone, V. Sans, M. H. Rosnes, P. J. Kitson, L. Cronin* Beilstein Journal of Organic Chemistry 2013, 9, 951–959.
“Effects of fluid flow on the growth and assembly of ZnO nanocrystals in a continuous flow microreactor” C.-H. Choi, Y.-W. Su, C.-h. Chang* CrystEngComm 2013, 15, 3326–3333.
“Improving the catalytic performance of laccase using a novel continuous-flow microreactor” L. Lloret,* G. Eibes, M. T. Moreira, G. Feijoo, J. M. Lema, M. Miyazaki Chemical Engineering Journal 2013, 223, 497–506.
“Palladium-N-heterocyclic carbene (NHC) catalyzed C-N bond formation in a continuous flow microreactor. Effect of process parameters and comparison with batch operation” A. Pommella, G. Tomaiuolo,* A. Chartoire, S. Caserta, G. Toscano, S. P. Nolan, S. Guido Chemical Engineering Journal 2013, 223, 578–583.
“Continuous flow synthesis of tungsten oxide (WO3) nanoplates from tungsten(VI) ethoxide” M. Gimeno-Fabra, P. Dunne, D. Grant, P. Gooden, E. Lester* Chemical Engineering Journal 2013, 226, 22–29.
“A continuous-flow process for the synthesis of artemisinin” D. Kopetzki, F. Levesque, P. H. Seeberger* Chemistry” A European Journal 2013, 19, 5450–5456.
“C-glycosyl amino acids through hydroboration-cross-coupling of exo-glycals and their application in automated solid-phase synthesis” S. Koch, D. Schollmeyer, H. Löwe, H. Kunz* Chemistry - A European Journal 2013, 19, 7020–7041.
“Intramolecular [2+2] photocycloaddition of 3- and 4-(but-3-enyl)oxyquinolones: influence of the alkene substitution pattern, photophysical studies, and enantioselective catalysis by a chiral sensitizer” M. M. Maturi, M. Wenninger, R. Alonso, A. Bauer, A. Pöthig, E. Riedle,* T., Bach* Chemistry - A European Journal 2013, 19, 7461–7472.
“Rapid and continuous synthesis of cobalt aluminate nanoparticles under subcritical hydrothermal conditions with in-situ surface modification” J. Lu, K. Minami, S. Takami, T. Adschiri* Chemical Engineering Science 2013, 85, 50–54.
“Slug flow of ionic liquids in capillary microcontactors: fluid dynamic intensification for solvent extraction” F. Scheiff,* A. Holbach, D. W. Agar Chemical Engineering and Technology 2013, 36, 975–984.
“Kolbe-Schmitt flow synthesis in aqueous solution - from lab capillary reactor to pilot plant” U. Krtschil, V. Hessel, H.-J. Kost, D. Reinhard Chemical Engineering and Technology 2013, 36, 1010–1016.
“Generating gas-liquid-liquid three-phase microflows in a cross-junction microchannel device” K. Wang, Y. Lu, K. Qin, G. Luo, T. Wang Chemical Engineering and Technology 2013, 36, 1047–1060.
“Hydrogen production by dehydrogenation of formic acid on atomically dispersed gold on ceria” N. Yi, H. Saltsburg, M. Flytzani-Stephanopoulos* ChemSusChem 2013, 6, 816–819.
“A comprehensive study on the activity and deactivation of immobilized lecitase ultra in esterifications of food waste streams to monoacylglycerols” K. M. Goncalves, F. K. Sutili, I. I. Junior, M. C. Flores, L. S. de Mariz e Miranda, I. C. R. Leal, Y. Cordeiro, R. Luque, R. O. M. A. de Souza* ChemSusChem 2013, 6, 872–879.
“Continuous-flow synthesis of adipic acid from cyclohexene using hydrogen peroxide in high-temperature explosive regimes” M. Damm, B. Gutmann, C. O. Kappe* ChemSusChem 2013, 6, 978–982.
“Chemical conversion of sugars to lactic acid by alkaline hydrothermal processes” D. Esposito,* M. Antonietti ChemSusChem 2013, 6, 989–992.
“Aldol addition of dihydroxyacetone to N-Cbz-3-aminopropanal catalyzed by two aldolases variants in microreactors” M. Sudar, Z. Findrik,* D. Vasic-Racki, P. Clapes, C. Lozano Enzyme and Microbial Technology 2013, 53, 38–45.
“An alternative pathway for production of acetonitrile: ruthenium catalysed aerobic dehydrogenation of ethylamine” E. C. Corker, U. V. Mentzel, J. Mielby, A. Riisagera, R. Fehrmann* Green Chemistry 2013, 15, 928–933.
“Multistep synthesis of amides from alcohols and amines in continuous flow microreactor systems using oxygen and urea hydrogen peroxide as oxidants” X. Liu, K. F. Jensen* Green Chemistry 2013, 15, 1538–1541.
“Single-mode microwave reactor used for continuous flow reactions under elevated pressure” M. Nishioka,* M. Miyakawa, Y. Daino, H. Kataoka, H. Koda, K. Sato, T. M. Suzuki* Industrial & Engineering Chemistry Research 2013, 52, 4683–4687.
“Preparation of barium sulfate nanoparticles in an interdigital channel configuration micromixer SIMM-V2” H. Wu, C. Wang, C. Zeng, L. Zhang* Industrial & Engineering Chemistry Research 2013, 52, 5313–5320.
“The development of a capillary microreactor for transesterification reactions using lipase immobilized onto a silica monolith” S. T. Anuar, Y.-Y. Zhao, S. M. Mugo, J. M. Curtis* Journal of Molecular Catalysis B: Enzymatic 2013, 92, 62–70.
“Hydrazine-mediated reduction of nitro and azide functionalities catalyzed by highly active and reusable magnetic iron oxide nanocrystals” D. Cantillo, M. M. Moghaddam, C. O. Kappe* Journal of Organic Chemistry 2013, 78, 4530–4542.
“Efficient [2+2] photocycloadditions under equimolar conditions by employing a continuous UV-flow reactor” M. Conradi, T. Junkers* Journal of Photochemistry and Photobiology A: Chemistry 2013, 259, 41–46.
“Microwave dielectric heating of non-aqueous droplets in a microfluidic device for nanoparticle synthesis” D. Koziej,* C. Floryan, R. A. Sperling, A. J. Ehrlicher, D. Issadore, R. Westervelt, D. A. Weitza Nanoscale 2013, 5, 5468–5475.
“Ethyl acetate as an acyl donor in the continuous flow kinetic resolution of (±)-1-phenylethylamine catalyzed by lipases” A. S. de Miranda, L. S. M. Miranda, R. O. M. A. de Souza* Organic & Biomolecular Chemistry 2013, 11, 3332–3336.
“Photocatalytic synthesis of allylic trifluoromethyl substituted styrene derivatives in batch and flow” L. M. Kreis, S. Krautwald, N. Pfeiffer, R. E. Martin,* E. M. Carreira* Organic Letters 2013, 15, 1634–1637.
“Pauson-Khand reactions in a photochemical flow microreactor” K. Asano, Y. Uesugi, J.-i. Yoshida* Organic Letters 2013, 15, 2398–2401.
“Highly selective phosgene-free carbamoylation of aniline by dimethyl carbonate under continuous-flow conditions” S. Grego, F. Aricò, P. Tundo* Organic Process Research and Development 2013, 17, 679–683.
“Mass transport and reactions in the tube-in-tube reactor” L. Yang, K. F. Jensen* Organic Process Research and Development 2013, 17, 927–933.
“One-step continuous process for the production of 1-butanol and 1-hexanol by catalytic conversion of bioethanol at its sub-/supercritical state” H. S. Ghaziaskar, C. (C.) Xu* RSC Advances 2012, 3, 4271–4280.
“Ozonolysis of some complex organic substrates in flow” M. D. Roydhouse,* W. B. Motherwell, A. Constantinou, A. Gavriilidis,* R. Wheeler, K. Down, I. Campbell RSC Advances 2012, 3, 5076–5082.
“Meso-scale microwave-assisted continuous flow reactions utilizing a selective heating matrix” M. J. Karney, K. A. Porter, E. K. Barnhardt, G. S. Vanier* RSC Advances 2012, 3, 7106–7111.
“A supported aqueous phase catalyst coating in micro flow Mizoroki-Heck reaction” S. C. Stouten, Q. Wang, T. Noël, V. Hessel* Tetrahedron Letters 2013, 54, 2194–2198.
“Efficient and scalable synthesis of ketones via nucleophilic Grignard addition to nitriles using continuous flow chemistry” C. Mateos,* J. A. Rinc ón, J. Villanueva Tetrahedron Letters 2013, 54, 2226–2230.
“Continuous process for click reactions using glass micro-reactor functionalized with β-cyclodextrin” M. N. Tahir, R.-ul Qamar, A. Adnan, E. Cho, S. Jung,* Tetrahedron Letters 2013, 54, 3268–3237.
“Synthesis of 12-membered macrocyclic templates and library analogs for PPI” J. Chen,* F. Rong, B. Shan, Y. Chen, Y. Li, H. Yu, L. Chen, T. Kuang, S. Li, Y. Chen, J. Du, C. Ai, J. Li, X. Li, C. Shi, Z.G. Jiang, Y. Long, Q. Gao, Z. Wang, K. Xu, X. Ran, H. Yi, D. Zhao, H. Qiao, J. Shen, B. Liu, C. Liu, K. Wu, X. Geng, J. Tan, D. McLeod, H. Frost, G. Bai, G. Goetz, J. Federico III, C. Whitney-Pickett, M. Troutman, M. C. Noe, C. Guimaraes, D. W. Piotrowski, T. V. Magee Tetrahedron Letters 2013, 54, 3298–3301.
“Studies of a diastereoselective electrophilic fluorination reaction employing a cryo-flow reactor” K. Nakayama, D. L. Browne, I. R. Baxendale, S. V. Ley* Synlett 2013, 24, 1298–1302.
“Recent advances in asymmetric catalysis in flow” D. Zhao,* K., Ding* ACS Catalysis 2013, 3, 928–944.
“Accelerating photoredox catalysis in continuous microflow” T. Noël, X. Wang, V. Hessel Chemistry Today (Monographic Supplement Series) 2013, 31, 10–16.
“Continuous processes - sustainable manufacturing” J. Schrickel Chemistry Today 2013, 31, 22–25.
“Smart enzyme immobilization in microstructured reactors” J. M. Bolivar, B. Nidetzky Chemistry Today 2013, 31, 50–54.
“Flow chemistry for designing sustainable chemical synthesis” B. R. Vaddula, M. A. Gonzalez Chemistry Today 2013, 31, 16–20.
“Emerging catalytic processes for the production of adipic acid” S. Van de Vyver, Y. Roman-Leshkov* Catalysis Science & Technology 2013, 3, 1465–1465.
“Novel process windows for enabling, accelerating, and uplifting flow chemistry” V. Hessel,* D. Kralisch, N. Kockmann, T. Noël, Q. Wang ChemSusChem 2013, 6, 746–789.
“The role of flow in green chemistry and engineering” S. G. Newman, K. F. Jensen* Green Chemistry 2013, 15, 1456–1472.
“The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib” B. J. Deadman, M. D. Hopkin, I. R. Baxendale, S. V. Ley* Organic & Biomolecular Chemistry 2013, 11, 1766–1800.
“Latest highlights in liquid-phase reactions for organic synthesis in microreactors” L. N. Protasova,* M. Bulut, D. Ormerod, A. Buekenhoudt, J. Berton, C. V. Stevens Organic Process Research and Development 2013, 17, 760–791.