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  • 1 Université de Toulouse, INSA, UPS, INP; LISBP, 135 Avenue de Rangueil, F-31077, Toulouse, France
  • 2 INRA, UMR792 Ingénierie des Systèmes Biologiques et des Procédés, F-31400, Toulouse, France
  • 3 CNRS, UMR5504, F-31400, Toulouse, France
  • 4 Institut Clément Ader, INSA, 135 Avenue de Rangueil, F-31077, Toulouse, France
  • 5 Laboratoire de Génie Chimique, UMR 5503, BP 84234, Campus INP-ENSIACET, 4 allée Emile Monso, 31432, Toulouse cedex 4, France
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This work concerns the separation of a mixture of bi-dispersed spherical micro-particles by lateral migration at moderate Reynolds numbers. The expected differential focalization on annular rings of particles flowing in a circular micro-channel according to their size could be of interest for separation processes of poly-dispersed bio-particles suspensions. We propose an original and simple experimental method to study fluorescent particle migration at the microscale which is based on an indirect visualization of their position in a micro-channel. The particles are harvested on a plane filtration membrane put perpendicularly at the outlet of the channel. Their distribution on the membrane is then observed by fluorescent microscopy. A numerical simulation (COMSOL Multiphysics®) was developed to study the influence of membrane permeability and channel/membrane relative positions on the flow streamlines and on the subsequent size of the annular ring formed on the membrane by the focused particles. First experiments have been performed with suspensions of 1 and 4.8 μm diameter particles in order to correlate their positions to experimental conditions.

  • 1. M. Mota J. A. Teixeira A. Yelshin 2002 Sep. Purif. Technol. 27 137144.

  • 2. Y. P. Zhang A. G. Fane A. W. K. Law 2006 J. Membr. Sci. 282 189197.

  • 3. G. Foley 2006 J. Membr. Sci. 274 3846.

  • 4. Beaufort, S.; Alfenore, S.; Lafforgue, C. J. Membr. Sci. 2011, 369, 12, 3039.

  • 5. F. Altena G. Belfort 1984 Chemical Engineering Science 39 343355.

  • 6. G. Segré A. Silberberg 1962 J. Fluid Mech. 4 136157.

  • 7. J. P. Matas J. F. Morris E. Guazzelli 2004 IFP, Institut Français du Pétrole 59 5970.

  • 8. A. A. S. Bhagat S. S. Kuntaegowdanahalli I. Papautsky 2009 Microfluid Nanofluid 7 217226.

  • 9. D. Di Carlo D. Irimia R. G. Tompkins M. Toner 2007 Proc. Natl. Acad. Sci. U.S.A. 104 18892.

  • 10. Magaud, P.; Geoffroy, S.; Colin, S.; Baldas, L. 2nd European Conference on Microfluidics, Toulouse, μFLU2010, 2010, 113.

  • 11. J. Günther P. Schmitz C. Albasi C. Lafforgue 2010 J. Membr. Sci. 348 277286.

  • 12. P. Schmitz M. Prat 1995 AIChE J. 41 22122226.

  • 13. Elimelech, M. Particle Deposition and Aggregation: Measurement, Modelling and Simulation, Colloid and Surface Engineering Series, 1995, Elsevier.

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  • 14. D. Di Carlo J. F. Edd K. J. Humphry H. A. Stone M. Toner 2009 Phys. Rev. Lett. 102 094503.