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  • 1 Center for Biomedical and Life Sciences, Singapore Polytechnic, 500, Dover Road, 139651, Singapore
  • 2 School of Chemical and Life Sciences, Singapore Polytechnic, 500, Dover Road, 139651, Singapore
  • 3 School of Mechanical and Aeronautical Engineering, Singapore Polytechnic, 500, Dover Road, 139651, Singapore
  • 4 Engineering Product Development, Singapore University of Technology and Design, 20, Dover Drive, 138682, Singapore
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Abstract

An ultrasound irradiated continuous-flow system was developed to accelerate chemical reaction by cavitation effect. Nucleophilic aromatic substitutions were performed, and the results showed that ultrasound irradiated is superior over generic heating in a continuous-flow system. The combination of micro-cavitation and flow chemistry synergistically enhanced the reaction yield and rate while maintaining the reaction at a much lower temperature.

Supplementary Materials

    • Supplementary Material