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  • 1 Institute of Chemistry, Karl-Franzens University Graz, Heinrichstrasse 28, A-8010, Graz, Austria
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Abstract

In this section of the journal, the continuous-flow chemistry literature of the preceding months is presented. Included are articles published in the period July–September 2013. Some key examples are highlighted in the formof graphical abstracts. The remaining publications in the field are then listed, ordered by journal name, with review articles grouped at the end.

  • “Steady-state continuous-flow purification by electrophoresis” F. J. Agostino, L. T. Cherney, V. Galievsky, S. N. Krylov* Angewandte Chemie International Edition 2013, 52, 72567260.

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  • “CuCrO2 delafossite: a stable copper catalyst for chlorine production” A. P. Amrute, G. O. Larrazabal, C. Mondelli, J. Perez-Ramirez* Angewandte Chemie International Edition 2013, 52, 97729775.

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  • “A single enantiomer (99%) directly from continuous-flow asymmetric hydrogenation” R. Duque, P. J. Pogorzelec, D. J. Cole-Hamilton* Angewandte Chemie International Edition 2013, 52, 98059807.

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  • In situ generation of diimide from hydrazine and oxygen: continuous-flow transfer hydrogenation of olefinsB. Pieber, S. T. Martinez, D. Cantillo, C. O. Kappe* Angewandte Chemie International Edition 2013, 52, 1024110244.

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  • “Surface patterning using two-phase laminar flow and in situ formation of aryldiazonium salts” A. J. Gross, V. Nock, M. I. J. Polson, M. M. Alkaisi, A. J. Downard* Angewandte Chemie International Edition 2013, 52, 1026110264.

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  • Continuous flow organocatalytic C−H functionalization and cross-dehydrogenative coupling reactions: visible light organophotocatalysis for multicomponent reactions and C−C, C−P bond formationsM. Rueping,* C. Vila, T. Bootwicha ACS Catalysis 2013, 3, 16761680.

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  • “Microfluidic-induced growth and shape-up of three-dimensional extended arrays of densely packed nanoparticles” J. Angly, A. Iazzolino, J.-B. Salmon, J. Leng,* S. P. Chandran, V. Ponsinet, A. Desert, A. Le Beulze, S. Mornet, M. Treguer-Delapierre, M. A. Correa-Duarte ACS Nano 2013, 7, 64656477.

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  • “A continuous flow solution to achieving efficient aerobic anti-Markovnikov Wacker oxidation” S. L. Bourne, S. V. Ley* Advanced Synthesis and Catalysis 2013, 355, 19051910.

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  • “Palladium supported on cross-linked imidazolium network on silica as highly sustainable catalysts for the Suzuki reaction under flow conditions” C. Pavia, E. Ballerini, L. A. Bivona, F. Giacalone, C. Aprile,* L. Vaccaro,* M., Gruttadauria* Advanced Synthesis and Catalysis 2013, 355, 20072018.

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  • “Development of a continuously operating process for the enantioselective synthesis of a β-amino acid ester via a solvent-free chemoenzymatic reaction sequence” S. Strompen, M. Weis, H. Grcger, L. Hilterhaus, A. Liesea* Advanced Synthesis and Catalysis 2013, 355, 23912399.

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  • “Flow microwave technology and microreactors in synthesis” I. R. Baxendale,* C. Hornung, S. V. Ley, J. de Mata Munoz Molina, A. Wikström Australian Journal of Chemistry 2013, 66, 131144.

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  • “Continuous flow synthesis of difluoroamine systems by direct fluorination” C. B. McPake, C. B. Murray, G. Sandford* Australian Journal of Chemistry 2013, 66, 145150.

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  • “Continuous flow synthesis of organic electronic materials — case studies in methodology translation and scale-up” H. Seyler, S. Haid, T.-H. Kwon, D. J. Jones, P. Bäuerle, A. B. Holmes, W. W. H. Wong* Australian Journal of Chemistry 2013, 66, 151156.

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  • “Continuous flow photochemistry for the rapid and selective synthesis of 2′-deoxy and 2′,3′-dideoxynucleosides” B. Shen, T. F. Jamison* Australian Journal of Chemistry 2013, 66, 157164.

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  • “Characterization of dispersion effects on reaction optimization and scale-up for a packed bed flow hydrogenation reactor” J. W. Eschelbach,* D. Wernick, M. C. Bryan, E. M. Doherty Australian Journal of Chemistry 2013, 66, 165171.

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  • “A two-stage continuous-flow synthesis of spirooxazine photochromic dyes” M. York,* A. Edenharter Australian Journal of Chemistry 2013, 66, 172177.

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  • “A multi-step continuous flow process for the N-demethylation of alkaloids” Y. Nakano, G. P. Savage, S. Saubern, P. J. Scammells, A. Polyzos* Australian Journal of Chemistry 2013, 66, 178182.

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  • Silica immobilized Hoveyda type pre-catalysts: convenient and reusable heterogeneous catalysts for batch and flow olefin metathesisW. Solodenko, A. Doppiu, R. Frankfurter, C. Vogt, A. Kirschning* Australian Journal of Chemistry 2013, 66, 178182.

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  • “Synthesis of RAFT block copolymers in a multi-stage continuous flow process inside a tubular reactor” C. H. Hornung, X. Nguyen, S. Kyi, J. Chiefari, S. Saubern* Australian Journal of Chemistry 2013, 66, 192198.

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  • “Generation and reactions of pyridyllithiums via Br/Li exchange reactions using continuous flow microreactor systems” A. Nagaki, D. Yamada, S. Yamada, M. Doi, D. Ichinari, Y. Tomida, N. Takabayashi, J.-i. Yoshida* Australian Journal of Chemistry 2013, 66, 199207.

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  • “Development and evaluation of a Raman flow cell for monitoring continuous flow reactions” G. Chaplain, S. J. Haswell,* P. D. I. Fletcher, S. M. Kelly, A. Mansfield Australian Journal of Chemistry 2013, 66, 208212.

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  • “Visible light-initiated preparation of functionalized polystyrene monoliths for flow chemistry” F. R. Bou-Hamdan, K. Krüger, K. Tauer, D. T. McQuade,* P. H. Seeberger Australian Journal of Chemistry 2013, 66, 213217.

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  • “Simple and rapid hydrogenation of p-nitrophenol with aqueous formic acid in catalytic flow reactors” R. Javaid,* S.-i. Kawasaki, A. Suzuki, T. M. Suzuki* Beilstein Journal of Organic Chemistry 2013, 9, 11561163.

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  • Hypervalent iodine/TEMPO-mediated oxidation in flow systems: a fast and efficient protocol for alcohol oxidationN. Ambreen, R. Kumar, T. Wirth* Beilstein Journal of Organic Chemistry 2013, 9, 14371442.

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  • “Controlled synthesis of poly(3-hexylthiophene) in continuous flow” H. Seyler, J. Subbiah, D. J. Jones, A. B. Holmes, W. W. H. Wong* Beilstein Journal of Organic Chemistry 2013, 9, 14921500.

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  • “Efficient continuous-flow synthesis of novel 1,2,3-triazole-substituted β-aminocyclohexanecarboxylic acid derivatives with gram-scale production” S. B. Ötvös, Á. Georgiádes, I. M. Mándity, L. Kiss, F. Fülöp* Beilstein Journal of Organic Chemistry 2013, 9, 15081516.

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  • “The rapid generation of isothiocyanates in flow” M. Baumann, I. R. Baxendale* Beilstein Journal of Organic Chemistry 2013, 9, 16131619.

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  • “Gallium-containing polymer brush film as efficient supported Lewis acid catalyst in a glass microreactor” R. Munirathinam, R. Ricciardi, R. J. M. Egberink, J. Huskens, M. Holtkamp, H. Wormeester, U. Karst, W. Verboom* Beilstein Journal of Organic Chemistry 2013, 9, 16981704.

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  • “[3 + 2]-Cycloadditions of nitrile ylides after photoactivion of vinyl azides under flow conditions” S. Cludius-Brandt, L. Kupracz, A. Kirschning* Beilstein Journal of Organic Chemistry 2013, 9, 17451750.

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  • “The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow” K. A. Roper, M. B. Berry, S. V. Ley* Beilstein Journal of Organic Chemistry 2013, 9, 17811790.

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  • “Ethyl diazoacetate synthesis in flow” M. M. E. Delville, J. C. M. van Hest, F. P. J. T. Rutjes* Beilstein Journal of Organic Chemistry 2013, 9, 18131818.

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  • Integrating reaction and analysis: investigation of higher-order reactions by cryogenic trappingS. Stockinger, O. Trapp* Beilstein Journal of Organic Chemistry 2013, 9, 18371842.

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  • Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: equipment interface and assessment in four medicinally-relevant reactionsT. A. Hamlin, N. E. Leadbeater* Beilstein Journal of Organic Chemistry 2013, 9, 18431852.

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  • “Continuous flow photocyclization of stilbenes — scalable synthesis of functionalized phenanthrenes and helicenes” Q. Lefebvre, M. Jentsch, M. Rueping* Beilstein Journal of Organic Chemistry 2013, 9, 18831890.

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  • “Extending the versatility of the Hemetsberger–Knittel indole synthesis through microwave and flow chemistry” N. Ranasinghe, G. B. Jones* Bioorganic & Medicinal Chemistry Letters 2013, 23, 17401742.

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  • “Heterogeneous catalysis in an oscillatory baffled flow reactor” V. C. Eze, A. N. Phan, C. Pirez, A. P. Harvey,* Adam F. Leeb, K. Wilson* Catalysis Science & Technology 2013, 3, 23732379.

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  • “One-step hydroxylation of benzene to phenol via a Pd capillary membrane microreactor” X. Wang,* X. Tan, B. Meng, X. Zhang, Q. Liang, H. Pana, S. Liu Catalysis Science & Technology 2013, 3, 23802391.

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  • Aqueous phase reforming in a microchannel reactor: the effect of mass transfer on hydrogen selectivityM. F. N. D'Angelo, V. Ordomsky, J. van der Schaaf, J. C. Schouten, T. A. Nijhuis* Catalysis Science & Technology 2013, 3, 28342842.

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  • Development of a continuous flow reactor for pharmaceuticals using catalytic monoliths: Pt/C selective oxidation of benzyl alcoholF. Al Badran, S. Awdry, S. T. Kolaczkowski* Catalysis Today 2013, 216, 229239.

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  • “On-chip catalytic microreactors for modern catalysis research” B.-B. Xu, Y.-L. Zhang,* S. Wei, H. Ding, H.-B. Sun* ChemCatChem 2013, 5, 20912099.

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  • “Direct synthesis of phenol from benzene and O2, regulated by NH3 on Pt/β and Pt-Re/ZSM-5 catalysts” L. Wang, S. Yamamoto, S. Malwadkar, S.-i. Nagamatsu, T. Sasaki, K. Hayashizaki, M. Tada, Y. Iwasawa* ChemCatChem 2013, 5, 22032206.

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  • “Picoliter droplets developed as microreactors for ultrafast synthesis of multi-color water-soluble CdTe quantum dots” S. Yao, Y. Shu, Y.-J. Yang, X. Yu, D.-W. Pang, Z.-L. Zhang* Chemical Communications 2013, 49, 71147116.

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  • “Near-infrared photothermal activation of microgels incorporating polypyrrole nanotransducers through droplet microfluidics” R.-C. Luo, S. Ranjan, Y. Zhang, C.-H. Chen* Chemical Communications 2013, 49, 78877889.

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  • “Shedding light on Brønsted acid catalysis — a photocyclization–reduction reaction for the asymmetric synthesis of tetrahydroquinolines from aminochalcones in batch and flow” H.-H. Liao, C.-C. Hsiao, E. Sugiono, M. Rueping* Chemical Communications 2013, 49, 79537955.

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  • “Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds” S. H. Liang, T. L. Collier, B. H. Rotstein, R. Lewis, M. Steck, N. Vasdev* Chemical Communications 2013, 49, 87558757.

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  • “High pressure plant for heterogeneous catalytic CO2 hydrogenation reactions in a continuous flow microreactor” B. Tidona, A. Urakawa, P. R. von Rohra* Chemical Engineering and Processing: Process Intensification 2013, 65, 5357.

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  • “Investigation into the effect of flow structure on the photocatalytic degradation of methylene blue and dehydroabietic acid in a spinning disc reactor” I. Boiarkina, S. Norris, D. A. Patterson* Chemical Engineering Journal 2013, 222, 159171.

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  • “Efficient continuous production of ionic liquids in a loop reactor — experimental and theoretical studies for the example of 1-ethyl-3-methylimidazolium ethyl sulphate” S. Willmes, A. Jess* Chemical Engineering Journal 2013, 222, 198208.

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  • “Continuous flow synthesis of tungsten oxide (WO3) nanoplates from tungsten (VI) ethoxide” M. Gimeno-Fabra, P. Dunne, D. Grant, P. Gooden, E. Lester* Chemical Engineering Journal 2013, 226, 2229.

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  • “Preparation of highly purified β-tricalcium phosphate ceramics with a microdispersion process” L. Du, Y. J. Wang, Y. C. Lu, G. S. Luo* Chemical Engineering Journal 2013, 226, 5561.

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  • “A two-phase segmented microfluidic technique for one-step continuous versatile preparation of zeolites” L. Yu, Y. Pan, C. Wang, L. Zhang* Chemical Engineering Journal 2013, 226, 7885.

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  • “Application of microstructured devices for continuous synthesis of tailored platinum nanoparticles” J. Baumgard, A.-M. Vogt, U. Kragl, K. Jähnisch, N. Steinfeldt* Chemical Engineering Journal 2013, 227, 137144.

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  • “Synthesis of Fe3O4@ZIF-8 magnetic core–shell microspheres and their potential application in a capillary microreactor” T. Zhang, X. Zhang,* X. Yan, L. Kong, G. Zhang, H. Liu, J. Qiu,* K. L. Yeung Chemical Engineering Journal 2013, 228, 398404.

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  • “Improving the quality of nanoparticle production by using a new biphasic synthesis in a slug flow microreactor” D. Arndt, J. Thöming, M. Bäumer* Chemical Engineering Journal 2013, 228, 10831091.

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  • Microreactors as tools in kinetic investigations: ethylene oxide formation on silver catalystT. Salmi,* J. H. Carucci, M. Roche, K. Eräanen, J. Wärna, D. Murzin Chemical Engineering Science 2013, 87, 306314.

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  • “Continuous synthesis of pyridocarbazoles and initial photophysical and bioprobe characterization” D. T. McQuade,* A. G. O'Brien, M. Dörr, R. Rajaratnam, U. Eisold, B. Monnanda, T. Nobuta, H.-G. Löhmannsröoben, E. Meggers, P. H. Seeberger Chemical Science 2013, 4, 40674070.

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  • Multistep continuous-flow synthesis in medicinal chemistry: discovery and preliminary structure–activity relationships of CCR8 ligandsT. P. Petersen, S. Mirsharghi, P. C. Rummel, S. Thiele, M. M. Rosenkilde, A. Ritzen,* T., Ulven* Chemistry—A European Journal 2013, 19, 93439350.

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  • “Thermal restructuring of silica-grafted TiClx species and consequences for epoxidation catalysis” P. Mania, R. Verel, F. Jenny, C. Hammond, I. Hermans* Chemistry—A European Journal 2013, 19, 98499858.

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  • Continuous-flow synthesis of CdSe quantum dots: a size-tunable and scalable approachM. M. Moghaddam, M. Baghbanzadeh,* A. Sadeghpour, O. Glatter, C. O. Kappe* Chemistry—A European Journal 2013, 19, 1162911636.

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  • “Ruthenium carbenes supported on mesoporous silicas as highly active and selective hybrid catalysts for olefin metathesis reactions under continuous flow” M. Bru, R. Dehn, J. H. Teles, S. Deuerlein, M. Danz, I. B. Müller, M. Limbach* Chemistry—A European Journal 2013, 19, 1166111671.

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  • Supramolecular polymerization in microfluidic channels: spatial control over multiple intermolecular interactionsM. Numata,* T. Kozawa Chemistry—A European Journal 2013, 19, 1262912634.

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  • “Hydrogen production through aqueous-phase reforming of ethylene glycol in a washcoated microchannel” M. F. N. D'Angelo, V. Ordomsky, V. Paunovic, J. van der Schaaf, J. C. Schouten, T. A. Nijhuis* ChemSusChem 2013, 6, 17081716.

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  • “Tether-free immobilized bifunctional squaramide organocatalysts for batch and flow reactions” G. Kardos, T. Soós* European Journal of Organic Chemistry 2013, 44904494.

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  • “Fluorenylmethoxycarbonyl-N-methylamino acids synthesized in a flow tube-in-tube reactor with a liquid–liquid semipermeable membrane” A. E. Buba, S. Koch,* H. Kunz,* H. Löwe European Journal of Organic Chemistry 2013, 45094513.

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  • “Highly efficient iron(0) nanoparticle-catalyzed hydrogenation in water in flow” R. Hudson, G. Hamasaka, T. Osako, Y. M. A. Yamada, C.-J. Li, Y. Uozumi,* A., Moores* Green Chemistry 2013, 15, 21412148.

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  • “Atom-economical in situ synthesis of BaSO4 as imaging contrast agents within poly(N-isopropylacrylamide) microgels using one-step droplet microfluidics” Q. Wang, D. Zhang, X. Yang, H. Xu, A. Q. Shen,* Y., Yang* Green Chemistry 2013, 15, 22222229.

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  • “Direct synthesis of hydrogen peroxide in water in a continuous trickle bed reactor optimized to maximize productivity” P. Biasi,* J., García-Serna,* A. Bittantea, T. Salmia Green Chemistry 2013, 15, 25022513.

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  • “Continuous-flow precipitation of hydroxyapatite at 37 °C in a meso oscillatory flow reactor” F. Castro,* A. Ferreira, F. Rocha, A. Vicente, J. A. Teixeira Industrial & Engineering Chemistry Research 2013, 52, 98169821.

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  • “Lipase-based biocatalytic flow process in a packed-bed microreactor” I. Dencic, S. de Vaan, T. Noël, J. Meuldijk, M. de Croon, V. Hessel* Industrial & Engineering Chemistry Research 2013, 52, 1095110960.

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  • “Phenylacetylene hydrogenation over [Rh(NBD)(PPh3)2]BF4 catalyst in a numbered-up microchannels reactor” M. Al-Rawashdeh, J. Zalucky, C. Müller, T. A. Nijhuis, V. Hessel, J. C. Schouten* Industrial & Engineering Chemistry Research 2013, 52, 1151611526.

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  • “Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform” B. Desai, K. Dixon, E. Farrant, Q. Feng, K. R. Gibson, W. P. van Hoorn, J. Mills, T. Morgan, D. M. Parry, M. K. Ramjee, C. N. Selway,* G. J. Tarver, G. Whitlock, A. G. Wright Journal of Medicinal Chemistry 2013, 56, 30333047.

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  • “Synthesis of all four stereoisomers of 3-(tert-butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid” B. Bakonyi, M. Furegati,* C. Kramer, L. La Vecchia, F. Ossola Journal of Medicinal Chemistry 2013, 78, 93289339.

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  • “Lipase-catalyzed esterification of steric hindered fructose derivative by continuous flow and batch conditions” F. K. Sutili, H. S. Ruelaa, S. G. F. Leite, L. S. de M. Mirandaa, I. C. R. Leala, R. O. M. A. de Souzaa* Journal of Molecular Catalysis B: Enzymatic 2013, 85–86, 3742.

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  • “How the mode of Candida antarctica lipase B immobilization affects the continuous-flow kinetic resolution of racemic amines at various temperatures” Z. Boros, P. Falus, M. Markus, D. Weiser, M. Olah, G. Hornyanszky, J. Nagy, L. Poppe* Journal of Molecular Catalysis B: Enzymatic 2013, 85–86, 119125.

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  • “Microfluidic multi-input reactor for biocatalytic synthesis using transketolase” J. Lawrence, B. O'Sullivan, G. J. Lye, R. Wohlgemuth, N. Szita* Journal of Molecular Catalysis B: Enzymatic 2013, 95, 111117.

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  • Copper-mediated controlled radical polymerization in continuous flow processes: synergy between polymer reaction engineering and innovative chemistryN. Chan, M. F. Cunningham, R. A. Hutchinson Journal of Polymer Science Part A: Polymer Chemistry 2013, 51, 30813096.

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  • “An automated Teflon microfluidic peptide synthesizer” H. Zheng, W. Wang, X. Li, Z. Wang, L. Hood, C. Lausted,* Z., Hu* Lab on a Chip 2013, 13, 33473350.

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  • “Design of a prototype flow microreactor for synthetic biology in vitro” C. R. Boehm, P. S. Freemont,* O., Ces* Lab on a Chip 2013, 13, 34263432.

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  • “Microwave sensing and heating of individual droplets in microfluidic devices” M. S. Boybay, A. Jiao, T. Glawdel, C. L. Ren* Lab on a Chip 2013, 13, 38403846.

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  • “Micro flow reactor chips with integrated luminescent chemosensors for spatially resolved on-line chemical reaction monitoring” L. Gitlin, C. Hoera, R. J. Meier, S. Nagl, D. Belder* Lab on a Chip 2013, 13, 41344141.

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  • “Flow-directed loading of block copolymer micelles with hydrophobic probes in a gas−liquid microreactor” C.-W. Wang, A. Bains, D. Sinton, M. G. Moffitt* Langmuir 2013, 29, 83858394.

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  • “Highly sensitive ZnO nanorod- and nanoprism-based NO2 gas sensors: size and shape control using a continuous hydrothermal pilot plant” L. Shi,* A. J. T. Naik, J. B. M. Goodall, C. Tighe, R. Gruar, R. Binions,* I. Parkin,* J., Darr* Langmuir 2013, 29, 1060310609.

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  • “Microfluidics assisted fabrication of microspheres by poly(2-hydroxyethyl methacrylate)-block-poly(L-histidine) hybrid materials and their utilization as potential drug encapsulants” R. P. Johnson, E. Choi, K. Mi Lee, S. J. Yu, H. C. Chang, H. Suh, I. Kim Microfluidics and Nanofluidics 2013, 14, 257263.

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  • “Fabrication of nanoassemblies using flow control” C. Ropp, Z. Cummins, S. Nah, S. Qin, J. H. Seog, S. B. Lee, J. T. Fourkas,* B. Shapiro,* E., Waks* Nano Letters 2013, 13, 39363941.

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  • “A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir” L. Dalla-Vechia, B. Reichart, T. Glasnov, L. S. M. Miranda, C. O. Kappe,* R. O. M. A. de Souza* Organic & Biomolecular Chemistry 2013, 11, 68066813.

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  • “Continuous flow, highly enantioselective Michael additions catalyzed by a PS-supported squaramide” P. Kasaplar, C. Rodriguez-Escrich, M. A. Pericas* Organic Letters 2013, 15, 34983501.

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  • The Kondrat'eva reaction in flow: direct access to annulated pyridinesJ. Lehmann, T. Alzieu, R. E. Martin,* R., Britton* Organic Letters 2013, 15, 35503553.

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  • “Continuous-flow stereoselective organocatalyzed Diels–Alder reactions in a chiral catalytic “homemade” HPLC column” V. Chiroli, M. Benaglia,* F. Cozzi, A. Puglisi,* R. Annunziata, G. Celentano Organic Letters 2013, 15, 35903593.

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  • “Flow Heck reactions using extremely low loadings of phosphine-free palladium acetate” P. Cyr, S. T. Deng, J. M. Hawkins, K. E. Price* Organic Letters 2013, 15, 43424345.

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  • “On the potential of organic solvent nanofiltration in continuous Heck coupling reactions” L. Peeva, J. Arbour, A. Livingston* Organic Process Research and Development 2013, 17, 967975.

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  • “Epoxidation of soybean oil by continuous micro-flow system with continuous separation” W. He, Z. Fang, D. Ji, K. Chen, Z. Wan, X. Li, H. Gan, S. Tang, K. Zhang, K. Guo* Organic Process Research and Development 2013, 17, 11371141.

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  • “Full-scale continuous mini-reactor setup for heterogeneous Grignard alkylation of a pharmaceutical intermediate” M. J. Pedersen, T. L. Holm, J. P. Rahbek, T. Skovby, M. J. Mealy, K. Dam-Johansen, S. Kiil* Organic Process Research and Development 2013, 17, 11421148.

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  • Scaling up of continuous flow processes with gases using a tube-in-tube reactor: inline titrations and fanetizole synthesis with ammoniaJ. C. Pastre, D. L. Browne, M. O'Brien, S. V. Ley* Organic Process Research and Development 2013, 17, 11831191.

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  • “Continuous flow-processing of organometallic reagents using an advanced peristaltic pumping system and the telescoped flow synthesis of (E/Z)-tamoxifen” P. R. D. Murray, D. L. Browne, J. C. Pastre, C. Butters, D. Guthrie, S. V. Ley* Organic Process Research and Development 2013, 17, 11921208.

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  • Asymmetric organocatalytic aldol reaction in water: mechanistic insights and development of a semi-continuously operating processG. Rulli, K. A. Fredriksen, N. Duangdee, T. Bonge-Hansen, A. Berkessel,* H., Gröger* Synthesis 2013, 45, 25122519.

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