Authors:
Natan Straathof Micro Flow Chemistry & Process Technology Department of Chemical Engineering and Chemistry Eindhoven University of Technology Den Dolech 2 5612 AZ Eindhoven The Netherlands

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Dannie Osch Micro Flow Chemistry & Process Technology Department of Chemical Engineering and Chemistry Eindhoven University of Technology Den Dolech 2 5612 AZ Eindhoven The Netherlands

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Arian Schouten Micro Flow Chemistry & Process Technology Department of Chemical Engineering and Chemistry Eindhoven University of Technology Den Dolech 2 5612 AZ Eindhoven The Netherlands

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Xiao Wang Harvard Medical School and Brigham & Women’s Hospital Harvard NeuroDiscovery Center 65 Landsdowne Street Cambridge, Massachusetts 02139 United States

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Jaap Schouten Chemical Reactor Engineering, Eindhoven University of Technology Department of Chemical Engineering and Chemistry Den Dolech 2 5612 AZ Eindhoven The Netherlands

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Volker Hessel Micro Flow Chemistry & Process Technology Department of Chemical Engineering and Chemistry Eindhoven University of Technology Den Dolech 2 5612 AZ Eindhoven The Netherlands

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Timothy Noël Micro Flow Chemistry & Process Technology Department of Chemical Engineering and Chemistry Eindhoven University of Technology Den Dolech 2 5612 AZ Eindhoven The Netherlands

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A visible light photocatalytic metal-free perfluoroalkylation method for the functionalization of heteroarenes in continuous flow was developed. Eosin Y was the most efficient photocatalyst with regard to substrate scope, reaction time and cost prize. Faster reaction times were observed in continuous flow compared to batch due to an improved irradiation of the reaction mixture on a microscale. Several pyrroles and indoles were perfluoroalkylated within 30 min residence time (six examples). The trifluoromethylation of pyrroles and indoles was achieved by using a gas–liquid flow with CF3I as a cheap CF3 source (three examples).

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Journal of Flow Chemistry
Language English
Size A4
Year of
Foundation
2011
Volumes
per Year
1
Issues
per Year
4
Founder Áramlásos Kémiai Tudományos Társaság
Founder's
Address
H-1031 Budapest, Hungary Záhony utca 7.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2062-249X (Print)
ISSN 2063-0212 (Online)