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  • 1 Karl-Franzens-University Graz Institute of Chemistry Heinrichstrasse 28 A-8010 Graz Austria
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In this section of the journal, the continuous flow chemistry literature of the preceding months is presented. Included are articles published in the period October–December 2013. Some key examples are highlighted in the form of graphical abstracts. The remaining publications in the field are then listed ordered by journal name, with review articles grouped at the end.

  • “A visible-light-mediated synthesis of carbazoles” A. C. Hernandez-Perez, S. K. Collins* Angewandte Chemie International Edition 2013, 52, 12696 –12700

  • “Organoytterbium ate complexes extend the value of cyclobutenediones as isoprene equivalents”E. Packard, D. D. Pascoe, J.S. Maddaluno, T. P. Gonçalves, D. C. Harrowven* Angewandte Chemie International Edition 2013, 52, 13076 –13079

  • “Homogeneous liquid-phase oxidation of ethylbenzene to acetophenone in continuous flow mode”B. Gutmann, P. Elsner, D. Roberge,* C. O. Kappe* ACS Catalysis 2013, 3, 2669–2676

  • “Single step reconstitution of multifunctional high-density lipoprotein-derived nanomaterials using microfluidics” Y. T. Kim, F. Fay, D. P. Cormode, B. L. Sanchez-Gaytan, J. Tang, E. J. Hennessy, M. Ma, K. Moore, O. C. Farokhzad, E. Allen Fisher, W. J. M. Mulder, R. Langer,* Z. A. Fayad* ACS Nano 2013, 7, 9975–9983

  • “Automated synthesis of photovoltaic-quality colloidal quantum dots using separate nucleation and growth stages” J. Pan, A. O. El-Ballouli, L. Rollny, O. Voznyy, V. M. Burlakov, A. Goriely, E. H. Sargent,* O. M. Bakr* ACS Nano 2013, 7, 10158–10166

  • “Generation of crystalline polyurethane foams using millifluidic lab-on-a-chip technologies”A. Testouri, M. Ranft, C. Honorez, N. Kaabeche, J. Ferbitz, D. Freidank, W. Drenckhan* Advanced Engineering Materials 2013, 15, 1086–1098

  • “One-step synthesis of pyridines and dihydropyridines in a continuous flow microwave reactor”M. C. Bagley,* V. Fusillo, R. L. Jenkins, M. C. Lubinu, C. Mason Beilstein Journal of Organic Chemistry 2013, 9, 1957–1968

  • “Microflow photochemistry: UVC-induced [2 + 2]-photoadditions to furanone in a microcapillary reactor” S. Bachollet, K. Terao, S. Aida, Y. Nishiyama, K. Kakiuchi, M. Oelgemöller* Beilstein Journal of Organic Chemistry 2013, 9, 2015–2021

  • “Flow synthesis of a versatile fructosamine mimic and quenching studies of a fructose transport probe” M. B. Plutschack, D. T. McQuade,* G. Valenti, P. H. Seeberger Beilstein Journal of Organic Chemistry 2013, 9, 2022–2027

  • “Temperature measurements with two different IR sensors in a continuous-flow microwave heated system” J. Rydfjord, F. Svensson, M. Fagrell, J. Sävmarker, M. Thulin, M. Larhed* Beilstein Journal of Organic Chemistry 2013, 9, 2079–2087

  • “Flow synthesis of phenylserine using threonine aldolase immobilized on Eupergit support”J. D. Tibhe, H. Fu, T. Noël, Q. Wang, J. Meuldijk, V. Hessel* Beilstein Journal of Organic Chemistry 2013, 9, 2168–2179

  • “Micro-flow synthesis and structural analysis of sterically crowded diimine ligands with five aryl rings”S. Fuse,* N. Tanabe, A. Tannna, Y. Konishi, T. Takahashi Beilstein Journal of Organic Chemistry 2013, 9, 2336–2343

  • “Synthesis of homo- and heteromultivalent carbohydrate-functionalized oligo(amidoamines) using novel glyco-building blocks”F. Wojcik, S. Lel, A. G. O’Brien, P. H. Seeberger,* L. Hartmann* Beilstein Journal of Organic Chemistry 2013, 9, 2395–2403

  • “A combined continuous microflow photochemistry and asymmetric organocatalysis approach for the enantioselective synthesis of tetrahydroquinolines”E. Sugiono,* M. Rueping* Beilstein Journal of Organic Chemistry 2013, 9, 2457–2462

  • “Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine”A. R. Longstreet, S. M. Opalka, B. S. Campbell, B. F. Gupton, D. T. McQuade* Beilstein Journal of Organic Chemistry 2013, 9, 2570–2578

  • “Rapid synthesis of propyl caffeate in ionic liquid using a packed bed enzyme microreactor under continuous-flow conditions”J. Wang,* S.-S. Gu, H.-S. Cui, L.-Q. Yang, X.-Y. Wu* Bioresource Technology 2013, 149, 367–374

  • “An evaluation of the effectiveness of continuous thin film processing in a spinning disc reactor for bulk free-radical photo-copolymerisation”C. G. Dobie, M. Vicevic, K. V. K. Boodhoo* Chemical Engineering and Processing: Process Intensification 2013, 71, 97–106

  • “Lignin oxidation studies in a continuous two-phase flow microreactor” H. Werhan, N. Assmann, P. R. von Rohr* Chemical Engineering and Processing: Process Intensification 2013, 73, 29–37

  • “A hybrid microreactor/microwave high-pressure flow system of a novel concept design and its application to the synthesis of silver nanoparticles”S. Horikoshia,* T. Sumia, N. Serponeb* Chemical Engineering and Processing: Process Intensification 2013, 73, 59–66

  • “Synthesis, crystal structure and photophysical properties of pyrene–helicene hybrids”A. C. Bedard, A. Vlassova, A. C. Hernandez-Perez, A. Bessette, G. S. Hanan, M. A. Heuft, S. K. Collins* Chemistry – A European Journal 2013, 19, 16295–16302

  • “Confined Au-Pd ensembles in mesoporous TiO2 spheres for the photocatalytic oxidation of acetaldehyde”F. Wang, Y. Jiang,* X. Wen, J. Xia, G. Sha, R. Amal* ChemCatChem 2013, 5, 3557–3561

  • “Silver nanoparticles for olefin production: new insights into the mechanistic description of propyne hydrogenation”G. Vile, D. Baudouin, I. N. Remediakis, C. Coperet,* N. Lopez,* J. Perez-Ramirez* ChemCatChem 2013, 5, 3750–3759

  • “Integrating continuous microflow reactions with subsequent micropreparative separations on a single microfluidic chip”S. Jezierski, V. Tehsmer, S. Nagl, D. Belder* Chemical Communications 2013, 49, 11644–11646

  • “Microstructured plate heat exchanger reactors for high temperature applications”G. Kolb,* T. Braune, J. Schürer, D. Tiemann Chemie Ingenieur Technik 2013, 85, 1619–1623

  • “A continuous ionic liquid extraction process for the separation of cobalt from nickel”S. Wellens, R. Goovaerts, C. Möller, J. Luyten, B. Thijsb, K. Binnemans* Green Chemistry 2013, 15, 3160–3164

  • “Impinging jet micromixer for flow synthesis of nanocrystalline mgo: role of mixing/impingement zone”D. V. R. Kumar, B. L. V. Prasad,* A. A. Kulkarni* Industrial & Engineering Chemistry Research 2013, 52, 12696 –12700

  • “Characterization and multi-step transketolase-?-transaminase bioconversions in an immobilized enzyme microreactor (IEMR) with packed tube” A. A. Halim, N. Szita, F. Baganz* Journal of Biotechnology 2013, 168, 567–575

  • “Microfluidic approach toward continuous and ultrafast synthesis of metal–organic framework crystals and hetero structures in confined microdroplets”M. Faustini, J. Kim, G.-Y. Jeong, J. Y. Kim, H. R. Moon,* W.-S. Ahn,* D.-P. Kim* Journal of the American Chemical Society 2013, 135, 14619–14626

  • “Separation of lysozyme with magnetically stabilized spherical hydroxyapatite microcomposites in a continuous flow system”B. Akkaya* Journal of Applied Polymer Science 2013, 1602–1610

  • “Direct preparation of nitriles from carboxylic acids in continuous flow”D. Cantillo, C. O. Kappe* Journal of Organic Chemistry 2013, 78, 10567–10571

  • “Ascertaining the suitability of aryl sulfonyl fluorides for [18F]radiochemistry applications: a systematic investigation using microfluidics”L. Matesic, N. A. Wyatt, B. H. Fraser,* M. P. Roberts, T. Q. Pham, I. Greguric Journal of Organic Chemistry 2013, 78, 11262–11270

  • “Batch and flow photochemical benzannulations based on the reaction of ynamides and diazo ketones. application to the synthesis of polycyclic aromatic and heteroaromatic compounds”T. P. Willumstad, O. Haze, X. Y. Mak, T. Y. Lam, Y.-P. Wang, R. L. Danheiser* Journal of Organic Chemistry 2013, 78, 11450–11469

  • “Reduction of uranyl nitrate ions in a continuous flow electrochemical reactor”K. Sini, S. Mishra, C. Mallika,* N. K. Pandey, F. Lawrence, U. K. Mudali, R. Natarajan* Journal of Radioanalytical and Nuclear Chemistry 2013, 295, 1505–1510

  • “Microfluidic production of spherical and nonspherical fat particles by thermal quenching of crystallizable oils”J. Kim, S. A. Vanapalli* Langmuir 2013, 29, 12307–12316

  • “Microfluidic fabrication of monodisperse polylactide microcapsules with tunable structures through rapid precipitation”T. Watanabe, Y. Kimura, T. Ono* Langmuir 2013, 29, 14082–14088

  • “Microreactors with integrated UV/Vis spectroscopic detection for online process analysis under segmented flow”J. Yue, F. H. Falke, J. C. Schouten, T. A. Nijhuis* Lab on a Chip 2013, 13, 4855–4863

  • “Phase transfer catalyzed esterification: modeling and experimental studies in a microreactor under parallel flow conditions”E. Sinkovec, A. Pohar, M. Krajnc* Microfluidics and Nanofluidics 2013, 14, 489–498

  • “A Multistep Flow Process for the Synthesis of Highly Functionalized Benzoxazoles”J. Sedelmeier,* F. Lima, A. Litzler, B. Martin, F. Venturoni* Organic Letters 2013, 15, 5546–5549

  • “Direct dehydrative esterification of alcohols and carboxylic acids with a macroporous polymeric acid catalyst”M. Minakawa, H. Baek, Y. M. A. Yamada,* J. W. Han, Y. Uozumi* Organic Letters 2013, 15, 5798–5801

  • “A safe and efficient flow oxidation of aldehydes with O2”L. Vanoye, A. Aloui, M. Pablos, R. Philippe, A. Percheron, A. Favre-Reguillon,* C. de Bellefon Organic Letters 2013, 15, 5978–5981

  • “The fit for purpose development of S1P1 receptor agonist GSK2263167 using a Robinson annulation and Saegusa oxidation to access an advanced phenol intermediate”R. M. Harris,* B. I. Andrews, S. Clark, J. W. B. Cooke, J. C. S. Gray, S. Q. Q. Ng Organic Process Research and Development 2013, 17, 1239–1246

  • “Continuous-flow aerobic oxidation of primary alcohols with a copper(I)/TEMPO catalyst”J. F. Greene, J. M. Hoover, D. S. Mannel, T. W. Root,* S. S. Stahl* Organic Process Research and Development 2013, 17, 1247–1251

  • “Kinetic analysis of aqueous-phase Pd-catalyzed, Cu-free direct arylation of terminal alkynes using a hydrophilic ligand”R. C. Domier, J. N. Moore, K. H. Shaughnessy,* R. L. Hartman* Organic Process Research and Development 2013, 17, 1262–12127

  • “Continuous flow tuning of ordered mesoporous silica under ambient conditions”C. L. Tong, R. A. Boulos, C. Yu, K. S. Iyer, C. L. Raston* RSC Advances 2013, 3, 18767–18770

  • “Separation of metathesis catalysts and reaction products in flow reactors using organic solvent nanofiltration”D. Ormerod,* B. Bongers, W. P. Carrero, S. Giegas, G. Vijt, N. Lefevre, D. Lauwers, W. Brustena, A. Buekenhoudt RSC Advances 2013, 3, 21501–21510

  • “Rapid continuous flow synthesis of high-quality silver nanocubes and nanospheres”H. Mehenni, L. Sinatra, R. Mahfouz, K. Katsiev, O. M. Bakr* RSC Advances 2013, 3, 22397–22403

  • “Droplet-based microreactors for continuous production of palladium nanocrystals with controlled sizes and shapes”Y. H. Kim, L. Zhang, T. Yu, M. Jin, D. Qin, Y. Xia* Small 2013, 9, 3462–3467

  • “Enzymatic reactions for the preparation of homocalycotomine enantiomers”L. Schönstein, E. Forro,* F. Fülöp* Tetrahedron: Asymmetry 2013, 24, 1059–1062

  • “Biotransformation with whole microbial systems in a continuous flow reactor: resolution of (RS)-flurbiprofen using Aspergillus oryzae by direct esterification with ethanol in organic solvent”L. Tamborini,* D. Romano, A. Pinto, M. Contente, M. C. Iannuzzi, P. Conti, F. Molinari Tetrahedron Letters 2013, 54, 6090–6093

  • “Flow synthesis of annulated 5-aryl-substituted pyridines by tandem intramolecular inverse-electron-demand hetero-/retro-Diels–Alder reaction”R. E. Martin,* M. Lenz, T. Alzieu, J. D. Aebi, L. Forzy Tetrahedron Letters 2013, 54, 6703–6707

  • “Arylation of pyridines via Suzuki–Miyaura cross-coupling and pyridine-directed C–H activation using a continuous-flow approach”M. Cristakakou, M. Schön, M. Schnürch,* M. D. Mihovilovic Synlett 2013, 14, 2411–2418