Journal of Flow Chemistry
Volume/Issue:
Volume 4: Issue 3
First Example of a Continuous-Flow Carbonylation Reaction Using Aryl Formates as CO Precursors
Authors:
Nerea Alonso Department of Medicinal Chemistry, Janssen Research and Development, Janssen-Cilag, S.A., C/Jarama, 75, 45007, Toledo, Spain
Facultad de Ciencias y Tecnologías Químicas, Universidad de Castilla-La Mancha, 13071, Ciudad Real, Spain

Search for other papers by Nerea Alonso in
Current site
Google Scholar
PubMed Close
,
M. Muñoz Juan de Department of Medicinal Chemistry, Janssen Research and Development, Janssen-Cilag, S.A., C/Jarama, 75, 45007, Toledo, Spain

Search for other papers by M. Muñoz Juan de in
Current site
Google Scholar
PubMed Close
,
Brecht Egle University of Leuven, Department of Chemistry, Molecular Design and Synthesis, Celestijnenlaan 200F, box 2404, BE3001, Heverlee, Belgium

Search for other papers by Brecht Egle in
Current site
Google Scholar
PubMed Close
,
Johannes L. Vrijdag University of Leuven, Department of Chemistry, Molecular Design and Synthesis, Celestijnenlaan 200F, box 2404, BE3001, Heverlee, Belgium

Search for other papers by Johannes L. Vrijdag in
Current site
Google Scholar
PubMed Close
,
Wim M. De Borggraeve University of Leuven, Department of Chemistry, Molecular Design and Synthesis, Celestijnenlaan 200F, box 2404, BE3001, Heverlee, Belgium

Search for other papers by Wim M. De Borggraeve in
Current site
Google Scholar
PubMed Close
,
Antonio de la Hoz Facultad de Ciencias y Tecnologías Químicas, Universidad de Castilla-La Mancha, 13071, Ciudad Real, Spain

Search for other papers by Antonio de la Hoz in
Current site
Google Scholar
PubMed Close
,
Angel Díaz-Ortiz Facultad de Ciencias y Tecnologías Químicas, Universidad de Castilla-La Mancha, 13071, Ciudad Real, Spain

Search for other papers by Angel Díaz-Ortiz in
Current site
Google Scholar
PubMed Close
, and
Jesús Alcázar Department of Medicinal Chemistry, Janssen Research and Development, Janssen-Cilag, S.A., C/Jarama, 75, 45007, Toledo, Spain

Search for other papers by Jesús Alcázar in
Current site
Google Scholar
PubMed Close
Pages:
105–109
Online Publication Date:
17 Sep 2014
Publication Date:
17 Sep 2014
Article Category:
Research Article
DOI:
https://doi.org/10.1556/jfc-d-14-00005
Keywords:
CO-free; carbonylation; flow chemistry; aryl formate; palladium
Restricted access

Abstract

The first continuous flow carbonylation reaction using aryl formates as CO precursor is reported. The reaction is practical, scalable and high yielding. The use of a flow protocol safely allows expanding the scope to activated chlorides, nitrogen heterocycles and to the selective introduction of an ester group in dihalo-derivatives. Further selective reduction of the ester formed to an aldehyde in flow is also described.

Supplementary Materials

    • Supplementary Material
  • Collapse
  • Expand
Cover Journal of Flow Chemistry
Journal of Flow Chemistry A Journal of the Flow Chemistry Society
Print ISSN:
2062-249X
Online ISSN:
2063-0212

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Flow Chemistry
Language English
Size A4
Year of
Foundation		 2011
Volumes
per Year		 1
Issues
per Year		 4
Founder Áramlásos Kémiai Tudományos Társaság
Founder's
Address		 H-1031 Budapest, Hungary Záhony utca 7.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 2062-249X (Print)
ISSN 2063-0212 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Oct 2024 51 0 0
Nov 2024 17 0 0
Dec 2024 2 0 0
Jan 2025 10 0 0
Feb 2025 8 0 1
Mar 2025 6 0 0
Apr 2025 0 0 0