Continuous-Flow Meerwein Arylation

Vinay Bhaya; Ramesh Joshi; Amol Kulkarni

doi:10.1556/jfc-d-14-00023

Jump to Content

Journal of Flow Chemistry

Volume/Issue:: Volume 4: Issue 4

Continuous-Flow Meerwein Arylation

Authors:

Vinay Bhaya

Vinay Bhaya CSIR—National Chemical Laboratory Chem. Eng. & Proc. Dev. Div. Pune India

Search for other papers by Vinay Bhaya in
Current site
Google Scholar
PubMed

Ramesh Joshi

Ramesh Joshi CSIR—National Chemical Laboratory Organic Chemistry Division Pune India

Search for other papers by Ramesh Joshi in
Current site
Google Scholar
PubMed

, and

Amol Kulkarni

Amol Kulkarni CSIR—National Chemical Laboratory Chem. Eng. & Proc. Dev. Div. Pune India

Search for other papers by Amol Kulkarni in
Current site
Google Scholar
PubMed

View More View Less

Pages:: 211–216

Online Publication Date:: 12 Nov 2014

Publication Date:: 10 Dec 2014

Article Category:: Research Article

DOI:: https://doi.org/10.1556/jfc-d-14-00023

Keywords:: flow chemistry; Meerwein arylation; homogeneous catalyst; diazonium salt; micromixer; multistep synthesis

Restricted access

The continuous-flow Meerwein arylation is demonstrated for a set of few aryl donors (anilines and m-aminoacetophenone) and specific radical acceptors. Homogeneous catalyst (CuBr in HBr and CuCl in HCl) was used to facilitate the reaction. The effect of parameters, viz., temperature, catalyst concentration, residence time, and concentration of the radical acceptor on the yield of the arylated product, was studied. The yield of the aryl derivative obtained by continuous-flow syntheses was always better than the respective experiments in batch mode. Flow synthesis allows easy variation in these parameters and thus allows going close to the maximum possible yields in a system where the relative rates of different reactions create a complex situation. Temperature plays a crucial role by affecting the rates as well as by governing the system homogeneity. The nitrogen bubbles generated in the reaction helped to avoid any channel blockage.

Supplementary Materials

Save
Cite
Email this content

Share Link

Copy this link, or click below to email it to a friend
Email this content
or copy the link directly:

https://akjournals.com/abstract/journals/1846/4/4/article-p211.xml
The link was not copied. Your current browser may not support copying via this button.

Link copied successfully

Collapse
Expand

Journal of Flow Chemistry A Journal of the Flow Chemistry Society

Print ISSN:: 2062-249X

Online ISSN:: 2063-0212

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Flow Chemistry
Language	English
Size	A4
Year of Foundation	2011
Volumes per Year	1
Issues per Year	4
Founder	Áramlásos Kémiai Tudományos Társaság
Founder's Address	H-1031 Budapest, Hungary Záhony utca 7.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	2062-249X (Print)
ISSN	2063-0212 (Online)