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  • 1 Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, A-8010 Graz, Austria
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In this section of the journal, the continuous-flow chemistry literature of the preceding months is presented. Included are articles published in the period October–December 2013 and January–March 2014. Some key examples are highlighted in the form of graphical abstracts. The remaining publications in the field are then listed ordered by journal name, with review articles grouped at the end.

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  • Heating under high-frequency inductive conditions: application to the continuous synthesis of the neurolepticum olanzapine (Zyprexa)J. Hartwig, S. Ceylan, L. Kupracz, L. Coutable, A. Kirschning* Angewandte Chemie International Edition 2013, 52, 98139817.

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  • Flow synthesis and biological studies of an analgesic adamantine derivative that inhibits P2X7-evoked glutamate releaseC. Battilocchio, L. Guetzoyan, C. Cervetto, L. D. C. Mannelli, D. Frattaroli, I. R. Baxendale G. Maura, A. Rossi, L. Sautebin, M. Biava, C. Ghelardini, M. Marcoli, S. V. Ley* ACS Medicinal Chemistry Letters 2013, 4, 704709.

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  • A continuous flow solution to achieving efficient aerobic anti-Markovnikov Wacker oxidationS. L. Bourne, S. V. Ley* Advanced Synthesis & Catalysis 2013, 355, 19051910.

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  • Copper(I)/N-heterocyclic carbene (NHC)-catalyzed addition of terminal alkynes to trifluoromethyl ketones for use in continuous reactorsC. A. Correia, D. T. McQuade,* P. H. Seeberger Advanced Synthesis & Catalysis 2013, 355, 35173521.

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  • Continuous-flow Heck synthesis of 4-methoxybiphenyl and methyl 4-methoxycinnamate in supercritical carbon dioxide expanded solvent solutionsP. L. Lau, R. W. K. Allen, P. Styring* Beilstein Journal of Organic Chemistry 2013, 9, 28862897.

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  • A microfluidic system for the continuous recycling of unmodified homogeneous palladium catalysts through liquid/liquid phase separationP. Li,* J. S. Moore, K. F. Jensen * ChemCatChem 2013, 5, 17291733.

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  • On-chip catalytic microreactors for modern catalysis researchB.-B. Xu, Y.-L. Zhang,* S. Wei, H. Ding, H.-B. Sun* ChemCatChem 2013, 5, 20912099.

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  • Multistep continuous-flow synthesis in medicinal chemistry: discovery and preliminary structure–activity relationships of CCR8 ligandsT. P. Petersen, S. Mirsharghi, P. C. Rummel, S. Thiele, M. M. Rosenkilde, A. Ritzen,* T. Ulven* Chemistry European Journal 2013, 19, 93439350.

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  • Two-phase enzymatic reaction using process intensification techniquesS. Elgue,* A. Conte,* A. Marty, J.-S. Condoret Chemistry Today 2013, 31(6), 4347.

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  • Efficient terpene synthase catalysis by extraction in flowO. Cascon, G. Richter, R. K. Allemann,* T. Wirth* ChemPlusChem 2013, 78, 13341337.

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  • Hydrogen production through aqueous-phase reforming of ethylene glycol in a wash coated microchannelM. F. N. D'Angelo, V. Ordomsky, V. Paunovic, J. van der Schaaf, J. C. Schouten, T. A. Nijhuis * ChemSusChem 2013, 6, 17081716.

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  • Asymmetric anti-Mannich reactions in continuous flowR. Martin-Rapun,* S. Sayaleroa, M. A. Pericas * Green Chemistry 2013, 15, 32953301.

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  • Microwave heating and conventionally-heated continuous-flow processing as tools for performing cleaner palladium-catalyzed decarboxylative couplings using oxygen as the oxidant — a proof of principle studyD. M. Rudzinski, N. E. Leadbeater* Green Processing & Synthesis 2013, 2, 323328.

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  • Integrated lipase-catalyzed isoamyl acetate synthesis in a miniaturized system with enzyme and ionic liquid recycleU. Novak, P. Znidarsic-Plazl* Green Processing & Synthesis 2013, 2, 561568.

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  • NADH oxidation in a microreactor catalysed by ADH immobilised on γ-Fe2O3 nanoparticlesA. Salic, K. Pindric, G. H. Podrepsek, M. Leitgeb,* B. Zelic * Green Processing & Synthesis 2013, 2, 569578.

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  • A comparative study of ultrasound-, microwave-, and microreactor-assisted imidazolium-based ionic liquid synthesisM. C. Bubalo, I. Sabotin, I. Rados, J. Valentincic, T. Bosiljkov, M. Brncic, P. Znidarsic-Plazl * Green Processing & Synthesis 2013, 2, 579590.

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  • Improving energy efficiency of process of direct adipic acid synthesis in flow using pinch analysisI. Vural-Gürsel, Q. Wang, T. Noël, V. Hessel,* J. T. Tinge Industrial & Engineering Chemistry Research 2013, 52, 78277835.

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  • ADH based NAD+ regeneration in a microreactorA. Salic, M. Ivankovic, E. Ferk, B. Zelic * Journal of Chemical Technology & Biotechnology 2013, 88, 17211729.

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  • Progress in computational microfluidics using TransATD. Lakehal, C. Narayanan, D. Caviezel, J. von Rickenbach, S. Reboux Microfluidics and Nanofluidics 2013, 15, 415429.

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  • Phase transfer catalyzed esterification: modeling and experimental studies in a microreactor under parallel flow conditionsE. Sinkovec, A. Pohar, M. Krajnc* Microfluidics and Nanofluidics 2013, 14, 489498.

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  • Application of continuous flow micromixing reactor technology for synthesis of benzimidazole drugsG. S. Reddy, N. S. Reddy, K. Manudhane, M. V. R. Krishna, K. J. S. Ramachandra, S. Gangula* Organic Process Research & Development 2013, 17, 12721276.

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  • Siloxane photopolymer to replace polydimethylsiloxane in microfluidic devices for polymerase chain reactionA. Vitale,* M. Quaglio, S. Turri, M. Cocuzza, R. Bongiovani Polymers Advanced Technologies 2013, 24, 10681074.

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  • Materials for Microfluidic Chip FabricationK. Ren, J. Zhou, H. Wu Accounts of Chemical Research 2013, 46, 23962406.

  • Asymmetric carbon–carbon bond formation under continuous-flow conditions with chiral heterogeneous catalystsT. Tsubogo, T. Ishiwata, S. Kobayashi* Angewandte Chemie International Edition 2013, 52, 65906604.

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  • Applications, benefits and challenges of flow chemistryA. Mitic, S. Heintz, R. H. Ringborg, V. Bodla, J. M. Woodley, K. V. Gernaey * Chemistry Today 2013, 31, 48.

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  • Flow chemistry approaches directed at improving chemical synthesisI. R. Baxendale,* L. Brocken, C. J. Mallia Green Processing & Synthesis 2013, 2, 211230.

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  • Multiphase biotransformations in microstructured reactors: opportunities for biocatalytic process intensification and smart flow processingJ. M. Bolivar, B. Nidetzky* Green Processing & Synthesis 2013, 2, 541559.

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  • Flow chemistry for designing sustainable chemical synthesisB. R. Vaddula, M. A. Gonzalez Chemistry Today 2013, 31, 1620.

  • Continuous processes — sustainable manufacturingJ. Schrickel Chemistry Today 2013, 31, 2225.

  • Smart enzyme immobilization in microstructured reactorsJ. M. Bolivar, B. Nidetzky Chemistry Today 2013, 31(3), 5054.

  • Accelerating photoredox catalysis in continuous microflowT. Noel Chemistry Today 2013, 31(3), 1014 (Monographic Supplement Series).

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  • “Batch kinetics in flow: online IR analysis and continuous controlJ. S. Moore, K. F. Jensen* Angewandte Chemie International Edition 2014, 53, 470473.

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  • Combining on-chip synthesis of a focused combinatorial library with computational target prediction reveals imidazopyridine GPSR ligandsM. Reutlinger, T. Rodrigues, P. Schneider, G. Schneider* Angewandte Chemie International Edition 2014, 53, 582585.

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  • Seamless integration of dose–response screening and flow chemistry: efficient generation of structure–activity relationship data of β-secretase (BACE1) inhibitorsM. Werner,* C. Kuratli, R. E. Martin,* R. Hochstrasser, D. Wechsler, T. Enderle, A. I. Alanine, H. Vogel Angewandte Chemie International Edition 2014, 53, 17041708.

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  • High-rate continuous synthesis of nanocrystalline perovskites and metal oxides in a colliding vapor stream of microdropletsT. Ould-Ely, L. Kaplan-Reinig, D. E. Morse* Advanced Functional Materials 2014, 24, 12751282.

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  • One-step two-dimensional microfluidics-based synthesis of three-dimensional particlesN. Hakimi, S. S. H. Tsai, C.-H. Cheng, D. K. Hwang* Advanced Functional Materials 2014, 24, 13931398.

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  • Synthesis of 3-arylated 3,4-dihydrocoumarins: combining continuous flow hydrogenation with laccase-catalysed oxidationS. Suljic, J. Pietruszka,* Advanced Synthesis & Catalysis 2014, 356, 10071020.

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  • Preparation of reusable bioreactors using reversible immobilization of enzyme on monolithic porous polymer support with attached gold nanoparticlesY. Lv, Z. Lin, T. Tan, F. Svec* Biotechnology & Bioengineering 2014, 111, 5058.

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  • Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamideR. J. Ingham, C. Battilocchio, J. M. Hawkins, S. V. Ley* Beilstein Journal of Organic Chemistry 2014, 10, 641652.

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  • Robust and reusable supported palladium catalysts for cross-coupling reactions in flowW. R. Reynolds, P. Plucinski, C. G. Frost* Catalysis Science & Technology 2014, 4, 948954.

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  • Heterogenized gold(I)–carbene as a single-site catalyst in continuous flowC. Lothschtz, J. Szlachetko, J. A. van Bokhoven* ChemCatChem 2014, 6, 443448.

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  • Reusable supported ruthenium catalysts for the alkylation of amines by using primary alcoholsS. P. Shan, T. T. Dang, A. M. Seayad, B. Ramalingam* ChemCatChem 2014, 6, 808814.

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  • Electrochemical conversion of dichloroacetic acid to chloroacetic acid in conventional cell and in two microfluidic reactorsO. Scialdone,* A. Galia, S. Sabatino, G. M. Vaiana, D. Agro, A. Busacca, C. Amatore ChemElectroChem 2014, 1, 116124.

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  • Investigation of a lithium–halogen exchange flow process for the preparation of boronates by using a cryo-flow reactorJ. A. Newby, L. Huck, D. W. Blaylock, P. M. Witt, S. V. Ley, D. L. Browne* Chemistry A European Journal 2014, 30, 263271.

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  • Enantioselective continuous-flow production of 3-indolylmethanamines mediated by an immobilized phosphoric acid catalystL. Osorio-Planes, C. Rodriguez-Escrich, M. A. Pericas* Chemistry A European Journal 2014, 30, 23672372.

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  • Biocompatible macro-initiators controlling radical retention in microfluidic on-chip photopolymerization of water-in-oil emulsionsY. Ma, J. Thiele, L. Abdelmohsen, J. Xu, W. T. S. Huck* Chemical Communications 2014, 50, 112114.

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  • Selective monomethylation of primary amines with simple electrophilesT. Lebleu, X. Ma, J. Maddaluno, J. Legros* Chemical Communications 2014, 50, 18361838.

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  • Controlling size, crystallinity, and electrochemical performance of Li4Ti5O12 nanocrystalsY. Shen, J. R. Eltzholtz, B. B. Iversen* Chemistry of Materials 2014, 25, 50235030.

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  • Mechanism-guided design of flow systems for multicomponent reactions: conversion of CO2 and olefins to cyclic carbonatesJ. Wu, J. A. Kozak, F. Simeon, T. A. Hatton,* T. F. Jamison* Chemical Science 2014, 5, 12271231.

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  • Catalytic transfer hydrogenation/hydrogenolysis for reductive upgrading of furfural and 5-(hydroxymethyl)furfuralD. Scholz, C. Aellig, I. Hermans* ChemSusChem 2014, 7, 268275.

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  • Tube-in-tube reactor as a useful tool for homo- and heterogeneous olefin metathesis under continuous flow modeK. Skowerski,* S. J. Czarnocki, P. Knapkiewicz ChemSusChem 2014, 7, 536542.

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  • Microfluidic platform for continuous flow synthesis of triangular gold nanoplatesD. V. R. Kumar, A. A. Kulkarni,* B. L. V. Prasad* Colloids and Surfaces A: Physicochemical and Engineering Aspects 2014, 443, 149155.

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  • Glucose-6-phosphate dehydrogenase encapsulated in silica-based hydrogels for operation in a microreactorS. Cumana,* I. Ardao, A.-P. Zeng, I. Smirnova Engineering in Life Sciences 2014, 14, 170179.

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  • A continuous process for glyoxal valorisation using tailored Lewis-acid zeolite catalystsP. Y. Dapsens, C. Mondelli,* B. T. Kusema, R. Verel, J. Perez-Ramirez* Green Chemistry 2014, 16, 11761186.

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  • Supported ionic liquid-like phases as organocatalysts for the solvent-free cyanosilylation of carbonyl compounds: from batch to continuous flow processS. Martin, R. Porcar, E. Peris, M. I. Burguete, E. Garcia-Verdugo,* S. V. Luis* Green Chemistry 2014, 16, 16391647.

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  • Olefin autoxidation in flowU. Neuenschwander, K. F. Jensen* Industrial & Engineering Chemistry Research 2014, 53, 601608.

  • Photocatalytic hydrodefluorination: facile access to partially fluorinated aromaticsS. M. Senaweera, A. Singh, J. D. Weaver* Journal of the American Chemical Society 2014, 136, 30023005.

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  • Continuous enzymatic carboligation of benzaldehyde and acetaldehyde in an enzyme ultrafiltration membrane reactor and laminar flow microreactorsD. Valingera,* A. V. Presecki, Z. Kurtanjek, M. Pohl, Z. F. Blazevic, D. Vasic-Racki Journal of Molecular Catalysis B: Enzymatic 2014, 102, 132137.

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  • Decarboxylative trichloromethylation of aromatic aldehydes and its applications in continuous flowA. B. Jensen, A. T. Lindhardt* Journal of Organic Chemistry 2014, 79, 11741183.

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  • Continuous flow synthesis of α-halo ketones: essential building blocks of antiretroviral agentsV. D. Pinho, B. Gutmann, L. S. M. Miranda, R. O. M. A. de Souza, C. O. Kappe* Journal of Organic Chemistry 2014, 79, 15551562.

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  • Comparison of flow and batch polymerization processes for production of vinyl ether terpolymers for use in the delivery of siRNAJ. L. Nyrop, A. Soheili, R. Xiang, F. Meng, J. H. Waldman, X. Jia, R. G. Parmar, B. W. Thuronyi, J. M. Williams, L. Di Michele, M. Journet, B. J. Howell, B. Mao, I. W. Davies, S. L. Colletti, L. Sepp-Lorenzino, E. N. Guidry* Journal of Polymer Science Part A: Polymer Chemistry 2014, 52, 11191129.

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  • High throughput synthesis of uniform biocompatible polymerbeads with high quantum dot loading using microfluidic jet-mode breakupS.-K. Lee, J. Baek, K. F. Jensen* Langmuir 2014, 30, 22162222.

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  • Scaled-up production of plasmonic nanoparticles using microfluidics: from metal precursors to functionalized and sterilized nanoparticlesL. Gomez, V. Sebastian,* S. Irusta, A. Ibarra, M. Arruebo, J. Santamaria* Lab on a Chip 2014, 14, 325332.

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  • Whole ceramic-like microreactors from inorganic polymers for high temperature or/and high pressure chemical synthesesW. Ren, J. Perumal, J. Wang, H. Wang, S. Sharmac, D.-P. Kim* Lab on a Chip 2014, 14, 779786.

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  • Continuous synthesis of zinc oxide nanoparticles in a microfluidic system for photovoltaic applicationH. W. Kang, J. Leem, S. Y. Yoon, H. J. Sung* Nanoscale 2014, 6, 28402846.

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  • Continuous flow α-trifluoromethylation of ketones by metal-free visible light photoredox catalysisD. Cantillo, O. de Frutos, J. A. Rincoon,* C. Mateos, C. O. Kappe* Organic Letters 2014, 16, 896899.

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  • Continuous photochemical cleavage of linkers for solid-phase synthesisM. Hurevich, J. Kandasamy, B. M. Ponnappa, M. Collot, D. Kopetzki, D. T. McQuade, P. H. Seeberger* Organic Letters 2014, 16, 17941797.

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  • Development of a multi-step synthesis and workup sequence for an integrated, continuous manufacturing process of a pharmaceuticalP. L. Heider, S. C. Born, S. Basak, B. Benyahia, R. Lakerveld, H. Zhang, R. Hogan, L. Buchbinder, A. Wolfe, S. Mascia, J. M. B. Evans, T. F. Jamison, K. F. Jensen* Organic Process Research and Development 2014, 18, 402409.

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  • Photo-induced copper-mediated polymerization of methyl acrylate in continuous flow reactorsB. Wenn, M. Conradi, A. D. Carreiras, D. M. Haddleton, T. Junkers* Polymer Chemistry 2014, 5, 30533060.

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  • Chemoselective flow hydrogenation approaches to isoindole-7-carboxylic acids and 7-oxa- bicyclio[2.2.1]heptanesL. Hizartzidis, M. Tarleton, C. P. Gordon, A. McCluskey* RSC Advances 2014, 4, 97099722.

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  • Flash carboxylation: fast lithiation–carboxylation sequence at room temperature in continuous flowB. Pieber, T. Glasnov, C. O. Kappe* RSC Advances 2014, 4, 1343013433.

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  • Two-step continuous-flow synthesis of CuInSe2 nanoparticles in a solar microreactorP. B. Kreider, K.-J. Kim, C.-H. Chang* RSC Advances 2014, 4, 1382713830.

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  • Nonenzymatic sugar production from biomass using biomass-derived γ-valerolactoneJ. S. Luterbacher, J. M. Rand, D. M. Alonso, J. Han, J. T. Youngquist, C. T. Maravelias, B. F. Pfleger, J. A. Dumesic* Science 2014, 343, 277280.

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  • Safe generation and direct use of diazoesters in flow chemistryS. T. R. Müller, D. Smith, P. Hellier, T. Wirth* Synlett 2014, 25, 871875.

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  • Continuous flow nitration in miniaturized devicesA. A. Kulkarni Beilstein Journal of Organic Chemistry 2014, 10, 405424.

  • Biocatalytic process development using microfluidic miniaturized systemsU. Krühne, S. Heintz, R. Ringborg, I. P. Rosinha, P. Tufvesson, K. V. Gernaey, J. M. Woodley* Green Processing & Synthesis 2014, 3, 2331.

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  • Microfluidic platforms: a mainstream technology for the preparation of crystalsJ. Puigmarti-Luis* Chemical Society Reviews 2014, 43, 22532271.

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