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  • 1 Eindhoven University of Technology Department of Chemical Engineering and Chemistry, Micro Flow Chemistry and Process Technology Den Dolech 2 5612 AZ Eindhoven The Netherlands
  • | 2 Drug Safety Sciences, Isotope Synthesis Janssen Research and Development Turnhoutseweg 30 2340 Beerse Belgium
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Deuterated compounds are important in drug discovery and development, e.g., to prepare the so-called stable isotopically labeled internal standards. However, their preparation can be challenging, and its scalability could be difficult with regard to safety aspects. Herein, we report the first continuous-flow iridium(I)-catalyzed ortho-directed hydrogen–deuterium exchange reaction in microreactors. An immobilized iridium(I) catalyst was loaded in continuous-flow microreactors, such as continuous stirred tank reactors and packed-bed reactors. Best results were obtained in a packed-bed reactor allowing deuterium labeling up to M +7.

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Journal of Flow Chemistry
Language English
Size A4
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