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  • 1 Karl-Franzens-University Graz Institute of Chemistry Heinrichstrasse 28 A-8010 Graz Austria
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In this section of the journal, the continuous-flow chemistry literature of the preceding months is presented. Included are articles published in the period July–December 2014. Some key examples are highlighted in the form of graphical abstracts. The remaining publications in the field are then listed ordered by journal name, with review articles grouped at the end. This will be the final part in this series.

  • “Continuous flow enantioselective three-component anti-Mannich reactions catalyzed by a polymer-supported threonine derivative” C. Ayats, A. H. Henseler, E. Dibello, M. A. Pericas* ACS Catalysis 2014, 4, 3027–3033

  • “Microfluidic-based generation of size-controlled, biofunctionalized synthetic polymer microgels for cell encapsulation” Devon M., Guillaume Aubry, Hang Lu, Andrés J. García* Advanced Materials 2014, 26, 3003–3008

  • “Synthesis of 3-arylated 3,4-dihydrocoumarins: combining continuous flow hydrogenation with Laccase-catalysed oxidation” Sanel Suljic, Jörg Pietruszka* Advanced Synthesis & Catalysis 2014, 356, 1007–1020

  • “Intermolecular [3 + 2] annulation of cyclopropylanilines with alkynes, enynes, and diynes via visible light photocatalysis” T. H. Nguyen, S. A. Morris, N. Zhenga* Advanced Synthesis & Catalysis 2014, 356, 2831–2837

  • “Generation of ethynyl-grignard reagent in a falling film microreactor: an expeditious flow synthesis of propargylic alcohols and analogues” Q. Deng, R. Shen,* R. Ding, L. Zhang* Advanced Synthesis & Catalysis 2014, 14–15, 2931–2936

  • “Microfluidic studies of carbon dioxide” M. Abolhasani, A. Günther, E. Kumacheva* Angewandte Chemie International Edition 2014, 53, 7992–8002

  • “Hydrogenation of sulfoxides to sulfides under mild conditions using ruthenium nanoparticle catalysts” T. Mitsudome, Y. Takahashi, T. Mizugaki, K. Jitsukawa, K. Kaneda* Angewandte Chemie International Edition 2014, 53, 8348–8351

  • “Continuous flow synthesis of ketones from carbon dioxide and organolithium or grignard reagents” J. Wu, X. Yang, Z. He, X. Mao, T. A. Hatton,* T. F. Jamison* Angewandte Chemie International Edition 2014, 53, 8416–8420

  • “Flow-based enzymatic ligation by Sortase A” R. L. Policarpo, H. Kang, X. Liao, A. E. Rabideau, M. D. Simon, B. L. Pentelute* Angewandte Chemie International Edition 2014, 53, 9203–9208

  • “Shifting chemical equilibria in flow — efficient decarbonylation driven by annular flow regimes” B. Gutmann, P. Elsner, T. Glasnov, D. M. Roberge,* C. O. Kappe* Angewandte Chemie International Edition 2014, 53, 11557–11561

  • “Microfluidic platform for combinatorial synthesis and optimization of targeted nanoparticles for cancer therapy” P. M. Valencia, E. M. Pridgen, M. Rhee, R. Langer,* O. C. Farokhzad,* R. Karnik* ACS Nano 2014, 7, 10671–10680

  • “The use of immobilized cytochrome P4502C9 in PMMA-based plug flow bioreactors for the production of drug metabolites” L. A. Wollenberg, J. L. Kabulski, M. J. Powell, J. Chen, D. R. Flora, T. S. Tracy, P. M. Gannett Applied Biochemistry and Biotechnology 2014, 172, 1293–1306

  • “Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide” R. J. Ingham, C. Battilocchio, J. M. Hawkins, S. V. Ley* Beilstein Journal of Organic Chemistry 2014, 10, 641–652

  • “A new charge-tagged proline-based organocatalyst for mechanistic studies using electrospray mass spectrometry” J. A. Willms, R. Beel, M. L. Schmidt, C. Mundt, M. Engeser* Beilstein Journal of Organic Chemistry 2014, 10, 2027–2037

  • “Hydration of acrylonitrile to produce acrylamide using biocatalyst in a membrane dispersion microreactor” J. Li, J. Chen, Y. Wang,* G. Luo, H. Yu Bioresource Technology 2014, 169, 416–420

  • “Selective synthesis of linear alkylbenzene by alkylation of benzene with 1-dodecene over desilicated zeolites” W. Aslama, M. A. B. Siddiquia, B. R. Jermya, A. Aitania, J. Cejka, S. Al-Khattaf* Catalysis Today 2014, 227, 187–197

  • “Kinetics of cyclooctene hydroformylation for continuous homogeneous catalysis” S. Güven, B. Hamers, R. Franke, M. Priske, M. Becker, D. Vogt* Catalysis & Science Technology 2014, 4, 524–530

  • “Dimerization of ethene in a fluidized bed reactor using Ni-based supported ionic liquid phase (SILP) catalysts” F. T. U. Kohler, K. Gärtner, V. Hager, M. Haumann,* M. Sternberg, X. Wang, N. Szesni, K. Meyer, P. Wasserscheid* Catalysis & Science Technology 2014, 4, 936–947

  • “Toward highly efficient photocatalysis: a flow-through Pt@TiO2@AAO membrane nanoreactor prepared by atomic layer deposition” H.-S. Chen,* P.-H. Chen, S.-H. Huang, T.-P. Perng* Chemical Communications 2014, 50, 4379–4382

  • “Catalytic nanoreactors in continuous flow: hydrogenation inside single-walled carbon nanotubes using supercritical CO2” T. W. Chamberlain,* J. H. Earley, D. P. Anderson, A. N. Khlobystov, R. A. Bourne* Chemical Communications 2014, 50, 5200–5202

  • “Highly porous conjugated polymers for selective oxidation of organic sulfides under visible light” Z. J. Wang, S. Ghasimi, K. Landfester, K. A. I. Zhang* Chemical Communications 2014, 50, 8177–8180

  • “Stereo- and chemoselective character of supported CeO2 catalysts for continuous-flow three-phase alkyne hydrogenation” G. Vile, S. Wrabetz, L. Floryan, M. E. Schuster, F. Girgsdies, D. Teschner, J. Perez-Ramirez* ChemCatChem 2014, 6, 1928–1934

  • “Effect of various Au/Al2O3 preparations on catalytic behavior during the continuous flow hydrogenation of an octanal/octene mixture” T. Chetty, H. B. Friedrich,* V. D. B. C. Dasireddy, A. Govender, P. J. Mohlala, W. Barnard ChemCatChem 2014, 6, 2384–2393

  • “Regioselective biocatalytic aromatic hydroxylation in a gas–liquid multiphase tube-in-tube reactor” B. Tomaszewski, R. C. Lloyd, A. J. Warr, K. Buehler, A. Schmid* ChemCatChem 2014, 6, 2567–2576

  • “Controllable preparation of nano-CaCO3 in a microporous tube-in-tube microchannel reactor” Y. Liang, G. Chu, J. Wang, Y. Huang, J. Chen, B. Sun,* L. Shao* Chemical Engineering and Processing: Process Intensification 2014, 79, 34–39

  • “Catalytic direct synthesis of hydrogen peroxide in a novel microstructured reactor” W. Ratchananusorn,* D. Gudarzi, I. Turunen Chemical Engineering and Processing: Process Intensification 2014, 84, 24–30

  • “Microreactor as efficient tool for light induced oxidation reactions” S. Hejda, M. Drhova, J. Kristal,* D. Buzek, P. Krystynik, P. Kluson Chemical Engineering Journal 2014, 255, 178–184

  • “Free-radical polymerization of styrene using a split-and-recombination (SAR) and multilamination microreactors” L. S. Mendez-Portillo, C. Dubois, P. A. Tanguy Chemical Engineering Journal 2014, 256, 212–221

  • “Preparation of highly dispersed precipitated nanosilica in a membrane dispersion microreactor” T. Zhang, Y. Wang,* G. Luo, S. Bai Chemical Engineering Journal 2014, 258, 327–333

  • “Triethanolamine synthesis in a continuous flow microchannel reactor” D. V. Andreev,* L. L. Makarshin, A. G. Gribovskii, D. Y. Yushchenko, E. E. Sergeev, E. G. Zhizhina, Z. P. Pai, V. N. Parmon Chemical Engineering Journal 2015, 259, 252–256

  • “Extremely fast gas/liquid reactions in flow microreactors: carboxylation of short-lived organolithiums” A. Nagaki, Y. Takahashi, J.-i. Yoshida* Chemistry A European Journal 2014, 20, 7931–7934

  • “Ultrafast continuous-flow synthesis of crystalline microporous aluminophosphate AlPO4-5” Z. Liu, T. Wakihara, D. Nishioka, K. Oshima, T. Takewaki, T. Okubo* Chemistry of Materials 2014, 26, 2327–2331

  • “Chitosan-microreactor: a versatile approach for heterogeneous organic synthesis in microfluidics” K. C. Basavaraju, S. Sharma, A. K. Singh, D. J. Im, D.-P. Kim* ChemSusChem 2014, 7, 1864–1869

  • “A continuous flow strategy for the coupled transfer hydrogenation and etherification of 5-(hydroxymethyl)furfural using Lewis acid zeolites” J. D. Lewis, S. Van de Vyver, A. J. Crisci, W. R. Gunther, V. K. Michaelis, R. G. Griffin, Y. Roman-Leshkov* ChemSusChem 2014, 7, 2255–2265

  • “Tunable and selective conversion of 5-HMF to 2,5-furandimethanol and 2,5-dimethylfuran over copper-doped porous metal oxides” A. J. Kumalaputri, G. Bottari, P. M. Erne, H. J. Heeres,* K. Barta* ChemSusChem 2014, 7, 2266–2275

  • “An efficient partial reduction of α,β-unsaturated esters using DIBAL-H in flow” M. Yoshida, H. Otaka, T. Doi* European Journal of Organic Chemistry 2014, 6010–6016

  • “A general continuous flow method for palladium catalysed carbonylation reactions using single and multiple tube-in-tube gas–liquid microreactors” U. Gross, P. Koos, M. O'Brien,* A. Polyzos, S. V. Ley European Journal of Organic Chemistry 2014, 29, 6418–6430

  • “Continuous flow synthesis of toxic ethyl diazoacetate for utilization in an integrated microfluidic system” R. A. Maurya, K.-I. Min, D.-P. Kim* Green Chemistry 2014, 16, 116–120

  • “Rapid Wolff–Kishner reductions in a silicon carbide microreactor” S. G. Newman, L. Gu, C. Lesniak, G. Victor, F. Meschke, L. Abahmane, K. F. Jensen* Green Chemistry 2014, 16, 176–180

  • “Three-component coupling based on flash chemistry. Carbolithiation of benzyne with functionalized aryllithiums followed by reactions with electrophiles” A. Nagaki, D. Ichinari, J.-i. Yoshida* Journal of the American Chemical Society 2014, 136, 12245–12248

  • “A scalable procedure for light-induced benzylic brominations in continuous flow” D. Cantillo, O. de Frutos, J. A. Rincon, C. Mateos,* C. O. Kappe* Journal of Organic Chemistry 2014, 79, 223–229

  • “Synthesis of benzobicycloheptanones via the trap of photogenerated ketene methide intermediate with olefins” Q. Liu, J. Meng, Y. Liu, C. Yang,* W Xia* Journal of Organic Chemistry 2014, 79, 8143–8155

  • “Continuous-flow Heck − Matsuda reaction: homogeneous versus heterogeneous palladium catalysts” N. Oger, E. Le Grognec, F.-X. Felpin* Journal of Organic Chemistry 2014, 79, 8255–8262

  • “A continuous-flow protocol for light-induced benzylic fluorinations” D. Cantillo, O. de Frutos,* J. A. Rincoon, C. Mateos, C. O. Kappe* Journal of Organic Chemistry 2014, 79, 8486–8490

  • “Whole ceramic-like microreactors from inorganic polymers for high temperature or/and high pressure chemical syntheses” W. Ren, J. Perumal, J. Wang, H. Wang, S. Sharma, D.-P. Kim* Lab on a Chip 2014, 14, 779–786

  • “Fabrication and characterisation of gold nano-particle modified polymer monoliths for flow-through catalytic reactions and their application in the reduction of hexacyanoferrate” P. Floris, B. Twamley, P. N. Nesterenko, B. Paull, D. Connolly* Microchimica Acta 2014, 181, 249–256

  • “Continuous flow synthesis and characterization of tailor-made bare gold nanoparticles for use in SERS” A. I. Lopez-Lorente, M. Valcarcel, B, Mizaikoff Microchimica Acta 2014, 181, 1101–1108

  • “Immobilization of peroxidase enzyme onto the porous silicon structure for enhancing its activity and stability” P. Sahare, M. Ayala, R. Vazquez-Duhalt, V. Agrawal* Nano Express 2014, 9, 409

  • “Self-assembled asymmetric catalyst engaged in a continuous-flow platform: an anti-selective catalytic asymmetric nitroaldol reaction” K. Hashimoto, N. Kumagai,* M. Shibasaki Organic Letters 2014, 16, 3496–3499

  • “A protocol to generate phthaloyl peroxide in flow for the hydroxylation of arenes” A. M. Eliasen, R. P. Thedford, K. R. Claussen, C. Yuan, D. Siegel* Organic Letters 2014, 16, 3628–3631

  • “Continuous process for production of CuCF3 via direct cupration of fluoroform” Z. Mazloomi, A. Bansode, P. Benavente, A. Lishchynskyi, A. Urakawa,* V. V. Grushin* Organic Process Research & Development 2014, 18, 1020–1026

  • “Fast synthesis of an inorganic–organic block copolymer in a droplet-based microreactor” P. H. Hoang,* L. Q. Dien RSC Advances 2014, 4, 8283–8288

  • “Zirconium–Beta zeolite as a robust catalyst for the transformation of levulinic acid to g-valerolactone via Meerwein–Ponndorf–Verley reduction” J. Wang, S. Jaenicke, G.-K. Chuah* RSC Advances 2014, 4, 13481–13489

  • “Systematic evaluation of the palladium-catalyzed hydrogenation under flow conditions” T. Hattori, A. Tsubone, Y. Sawama, Y. Monguchi,* H. Sajiki* Tetrahedron 2014, 70, 4790–4798