Scaling up the Throughput of Synthesis and Extraction in Droplet Microfluidic Reactors

Piotr M. Korczyk; Monika E. Dolega; Slawomir Jakiela; Pawel Jankowski; Sylwia Makulska; Piotr Garstecki

doi:10.1556/jfc-d-14-00038

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Journal of Flow Chemistry

Volume/Issue:: Volume 5: Issue 2

Scaling up the Throughput of Synthesis and Extraction in Droplet Microfluidic Reactors

Authors:

Piotr M. Korczyk

Piotr M. Korczyk Polish Academy of Sciences, Pawinskiego 5B, 02-106, Warsaw, Poland

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Monika E. Dolega

Monika E. Dolega LIPHY, F-38000, Grenoble, France
LIPHY, F-38000, Grenoble, France

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Slawomir Jakiela

Slawomir Jakiela Polish Academy of Sciences, Kasprzaka 44/52, 01-224, Warsaw, Poland

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Pawel Jankowski

Pawel Jankowski Polish Academy of Sciences, Kasprzaka 44/52, 01-224, Warsaw, Poland

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Sylwia Makulska

Sylwia Makulska Polish Academy of Sciences, Kasprzaka 44/52, 01-224, Warsaw, Poland

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Piotr Garstecki

Piotr Garstecki Polish Academy of Sciences, Kasprzaka 44/52, 01-224, Warsaw, Poland

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Pages:: 110–118

Online Publication Date:: Jun 2015

Publication Date:: 01 Jun 2015

Article Category:: Research Article

DOI:: https://doi.org/10.1556/jfc-d-14-00038

Keywords:: flow chemistry; microfluidics; synthesis; emulsions; droplets

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Conducting reactions in droplets in microfluidic chips offers several highly attractive characteristics, among others, increased yield and selectivity of chemical syntheses. The use of droplet microfluidic systems in synthetic chemistry is, however, hampered by the intrinsically small throughput of micrometric channels. Here, we verify experimentally the potential to increase throughput via an increase of the scale of the channels.We use the results of these experiments characterizing the processes of (1) generation of droplets, (2) mixing in droplets, (3) inter-phase extraction, and (4) the yield of synthesis of pyrrole, to postulate a number of guidelines for scaling up the throughput of microfluidic droplet systems. In particular, we suggest the rules for maximizing the throughput via an increase of the size of the channels and via parallelization to optimize the throughput of synthesis against the cost of fabrication of the chips and against the kinetic requirements of specific reactions.

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Journal of Flow Chemistry A Journal of the Flow Chemistry Society

Print ISSN:: 2062-249X

Online ISSN:: 2063-0212

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Journal of Flow Chemistry
Language	English
Size	A4
Year of Foundation	2011
Volumes per Year	1
Issues per Year	4
Founder	Áramlásos Kémiai Tudományos Társaság
Founder's Address	H-1031 Budapest, Hungary Záhony utca 7.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	2062-249X (Print)
ISSN	2063-0212 (Online)