Flow Alkylation of Thiols, Phenols, and Amines Using a Heterogenous Base in a Packed-Bed Reactor

Alastair Baker; Michael Graz; Robert Saunders; Gareth J. S. Evans; Ilaria Pitotti; Thomas Wirth

doi:10.1556/1846.2015.00009

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Journal of Flow Chemistry

Volume/Issue:: Volume 5: Issue 2

Flow Alkylation of Thiols, Phenols, and Amines Using a Heterogenous Base in a Packed-Bed Reactor

Authors:

Alastair Baker

Alastair Baker Cardiff University, Park Place, Main Building, Cardiff CF10 3AT, UK

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Michael Graz

Michael Graz Willowbrook Technical Units, Llandogo Road, St. Mellons, Cardiff CF3 0EF, UK

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Robert Saunders

Robert Saunders Willowbrook Technical Units, Llandogo Road, St. Mellons, Cardiff CF3 0EF, UK

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Gareth J. S. Evans

Gareth J. S. Evans Willowbrook Technical Units, Llandogo Road, St. Mellons, Cardiff CF3 0EF, UK

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Ilaria Pitotti

Ilaria Pitotti Cardiff University, Park Place, Main Building, Cardiff CF10 3AT, UK

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Thomas Wirth

Thomas Wirth Cardiff University, Park Place, Main Building, Cardiff CF10 3AT, UK

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Pages:: 65–68

Online Publication Date:: Jun 2015

Publication Date:: 01 Jun 2015

Article Category:: Research Article

DOI:: https://doi.org/10.1556/1846.2015.00009

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Rapid alkylations of thiols are performed in a packed-bed flow reactor where potassium carbonate acts as a heterogeneous base in anhydrous solvents at ambient temperature. The reaction also has a high efficiency as the removal of the solvent is the only work up required to isolate the product. The products can be used in a subsequent oxidation which was performed sequentially in semibatch mode. The alkylations of phenol and benzyl amine have been demonstrated on an array of bases, but higher temperatures and longer reaction times are required than with thiols.

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Journal of Flow Chemistry A Journal of the Flow Chemistry Society

Print ISSN:: 2062-249X

Online ISSN:: 2063-0212

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Journal of Flow Chemistry
Language	English
Size	A4
Year of Foundation	2011
Volumes per Year	1
Issues per Year	4
Founder	Áramlásos Kémiai Tudományos Társaság
Founder's Address	H-1031 Budapest, Hungary Záhony utca 7.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	2062-249X (Print)
ISSN	2063-0212 (Online)